ISSN:
1398-9995
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Histamine release induced by Staphylococcus aureus was examined in cells obtained by bronchoalveolar lavage (BAL) in non-topic individuals. Approximately half of the individuals responded with mediatior release to the bacterium, and the release was found to be time- and concentration dependent. No difference was found between the patients obtained by who responded and those who did not respond in regard to age, sex, smoker/nonsmoker % recovery of BAL-fluid, total cell count, differential cell counts, histamine content per mast cell, or diagnoses. Also stimulation of the BAL-cells with the calcium-ionophore A23187 resulted in histamine release, S. aureus-induced histamine release from basophils was examined in leukocyte suspensions obtained from the same individuals, and in all experiments release was found. The dose-response curves were similar to those obtained with BAL cells- The bacteria-induced mediator release from superficially lying cells in the airways epithelium might be of importance for the precipitation or exacerbation of bronchial asthma in respiratory tract infections.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1398-9995.1991.tb00542.x
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