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  • 1
    Digitale Medien
    Digitale Medien
    A model of hemopoietic stress in a lactate dehydrogenase mouse mutant with hemolytic anemia (1986)
    Springer
    Annals of hematology 52 (1986), S. 179-183 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Lactate dehydrogenase mutation ; Hemolytic anemia ; Hemopoietic regulation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A codominantly inherited mutation of the lactate dehydrogenase (LDH) in the C3H mouse causes a severe hemolytic anemia in homozygous mutants, whereas viability and fertility are close to normal. Investigation of multipotent hemopoietic stem cells (CFU-S), myeloid (GM-CFC) and erythroid progenitors (BFU-E, CFU-E) in femur and spleen indicates a general shift from bone marrow to splenic hemopoiesis. In terms of total body hemopoiesis, however, the BFU-E pool is 1.4- and the CFU-E pool 19-fold enlarged, whereas CFU-S and GM-CFC show little or no deviation from normal. It is concluded that this mouse mutant is an appropriate model of long-term hemopoietic stress showing that compensation in this severe hemolytic anemia is achieved primarily by an increase of the number of the most mature erythroid progenitors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320534
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  • 2
    Digitale Medien
    Digitale Medien
    Book reviews (1985)
    Springer
    Annals of hematology 51 (1985), S. 364-369 
    Details
    ISSN: 1432-0584
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320048
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  • 3
    Digitale Medien
    Digitale Medien
    Reproducible generation of autonomous malignant sublines from non-tumorogenic murine interleukin 3-dependent mast cell lines (1986)
    Springer
    Annals of hematology 53 (1986), S. 451-455 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Interleukin 3 (IL-3) ; Mast cells ; Neoplastic transformation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Murine interleukin 3 (IL-3)-dependent permanent mast cell lines derived from normal mouse bone marrow were established using pokeweed mitogenstimulated spleen cell conditioned medium (SCM) as a source of IL-3. When propagated continuously in media containing a high concentration of IL-3 (20% SCM or 20 U/ml murine recombinant IL-3 (rIL-3)), all the cell lines remained strictly factor-dependent in vitro and non-tumorogenic in vivo. However, we were able to reproducibly generate autonomous sublines from cultures supplemented with low amounts of IL-3 (1% SCM or 2 U/ml rIL-3). Abrogation of exogeneous growth factor dependency was always associated with neoplastic transformation. In newly generated autonomous sublines an autocrine mechanism of growth regulation was evident in vitro.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320309
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  • 4
    Digitale Medien
    Digitale Medien
    Proliferation kinetics of bone marrow cells in congenital dyserythropoietic anemia type II (1985)
    Springer
    Annals of hematology 50 (1985), S. 219-224 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Cell kinetics ; Congenital Dyserythropoietic Anemia ; Quantitative 14-C Autoradiography ; Ineffective Erythropoiesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The proliferation kinetics of erythropoiesis and of myelopoiesis have been studied in a case of congenital dyserythropoietic anemia type II (HEMPAS) by means of quantitative 14-C autoradiography, Feulgen cytophotometry and 59-Fe ferrokinetics. Increased total erythropoietic activity and ineffective erythopoiesis was demonstrated by ferrokinetics. Quantitative 14-C autoradiography showed a generally delayed proliferation rate of erythroid cells, most evident in the polychromatic compartment. A deficiency of cell production of 25% was detected among the polychromatic erythroblasts. Part of this fraction is represented by cells still capable of passing to the successive stages of maturation. We conclude that only part of the deficiency of cell production in the polychromatic compartment represents real cell destruction. Most of the measured ineffectiveness is confined to later stages of maturation, such as orthochromatic erthroblasts and marrow reticulocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320298
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  • 5
    Digitale Medien
    Digitale Medien
    In vitro hemopoiesis in human micro long-term bone marrow cultures recharged with either allogeneic, T-cell-depleted allogeneic, or syngeneic bone marrow cells (1990)
    Springer
    Annals of hematology 60 (1990), S. 228-232 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Micro long-term bone marrow cultures ; T cell depletion ; Allogeneic ; Syngeneic hemopoietic stem cells ; Hemopoietic precursor cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The production of granulocyte-macrophage colony-forming cells (GM-CFC) and the proliferation period in human long-term bone marrow cultures are inferior to murine cultures. There is also evidence that recharge of the cultures after establishing confluent stromal layers will not greatly improve myelopoiesis. Data in the literature indicate that PHA-responsive T lymphocytes persist for up to 5 weeks in human but not in murine long-term marrow cultures. We therefore analyzed the effects of recharging micro long-term bone marrow cultures with bone marrow cell samples depleted by T lymphocytes. Depletion was performed in a complement-mediated cytotoxicity assay by applying the monoclonal antibody CAMPATH-1. Our data show that regardless of whether T cells were removed only at recharge, at both initiation and recharge, or only at initiation, obvious enhancement could neither be achieved in the GM-CFC production nor in the proliferation period. Furthermore, no advantage was seen when using syngeneic marrow cells. We conclude that in allogeneic long-term marrow cultures hemopoiesis is not limited by immunological incompatibilities.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01728789
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