Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1990-1994  (5)
  • 1970-1974  (23)
  • 1955-1959  (9)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 329 (1971), S. 293-301 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Beobachtungen der „geographischen Pathologie” haben gezeigt, daß verschiedene Krebslokalisationen in verschiedenen Teilen der Erde mit teilweise extrem unterschiedlicher Häufigkeit auftreten. Dafür werden Ein flüsse der Umwelt bei den betrachteten Populationen verantwortlich gemacht. Lebensgewohnheiten, Sitten und Gebräuche bestimmen somit nicht nur das Krebsrisiko, sondern auch den Organbefall. Neben den bereits bekannten und gleichsam schon „historischen” Cancerogenen, wie z. B. höheren polycyclischen Aromaten oder aromatischen Aminen, wird in Gegenwart und Zukunft folgenden Problemen Bedeutung geschenkt werden müssen: 1. „Natürlich” vorkommende Carcinogene, z. B. in Pflanzen oder Mycotoxinen, 2. Pränatale Gefährdung durch Carcinogene, die transplancentar auf den Embryo einwirken, und 3. potentiell Carcinogene Arzneimittel, deren Kenntnis für den Arzt besonders wichtig erscheint. Instruktive Beispiele für diese drei Problemkreise werden aufgezeigt. Nach dem Stand unseres heutigen Wissens muß angenommen werden, daß die überwiegende Mehrzahl der Malignome durch exogene chemische Carcinogene bedingt ist.
    Notes: Summary Oberservations made in “geographical pathology” have shown that the various cancer sites seem to be affected with markedly different frequency in the various parts of the world. One assumes that the effects of environment on a particular population is responsible for this. Modes of life, habits and customs determine not only the cancer risk but also the organ that is likely to be affected. In addition to the already known and more or less “historical” cancerogens, such as for instance the polycyclic aromates or aromatic amines, we have now and in the future also to give some attention to the following problems: 1. “Naturally-occurring” carcinogens, for instance those originating in plants or as mycotoxins. 2. Pre-natal danger from carcinogens which can affect the embryo through the placenta and 3. potentially carcinogenous drugs, a knowledge of which seems specially important to the physician. Instructive examples of these three groups are given. According to the state of our knowledge to-day, one has to assume that the overwhelming majority of malignant tumours are caused by exogenous chemical carcinogens.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 12 (1956), S. 185-185 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Quantitative experiments in rats fed with 4-dimethylaminostilbene proved that the induction of ear-duct cancer is an irreversible “summation action”, similar to the production of hepatomas with 4-dimethylaminoazobenzene.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 69 (1991), S. 49-51 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 43 (1956), S. 199-199 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 44 (1957), S. 430-431 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 45 (1958), S. 16-17 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 45 (1958), S. 270-271 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 60 (1973), S. 55-55 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-1335
    Keywords: Antineoplastic efficacy ; Melphalan ; Diazoxide ; Insulin ; Mammary carcinoma ; Sprague-Dawley rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The anticancer activity of melphalan andN-(2-chloroethyl)-N-nitrosocarbamoyl-ω-lysine (CNC-ω-Lys), was compared in the autochthonous, methylnitrosourea-induced mammary carcinoma of the Sprague-Dawley rat. In addition, the influence on the therapeutic efficacy of the combination with diazoxide, causing a mild, reversible diabetes, and with insulin was investigated. The comparison of melphalan and CNC-ω-Lys clearly showed the superiority of melphalan. Both compounds displayed a significant tumour inhibition in their medium and the highest dosages in comparison to the untreated control. The combination with diazoxide resulted for almost all groups in an increased tumour inhibition. Only the lowest dose of CNC-ω-Lys + diazoxide did not reduce the tumour volume significantly versus the control group. The combination with insulin, however, resulted in a loss of tumour inhibition compared to the effect of the cytotoxic drug alone, although in these groups, too, a significant decrease of tumour volumes versus controls could be observed. Mortality was within tolerable limits (〈20%) through the treatment period for all experimental groups. Median lifespans were increased in all therapy groups, but no additional benefit could be observed in the combination treatment groups.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1432-1335
    Keywords: Bisphosphonates ; Osteosarcoma ; Bone metastasis ; Prophylactic treatment ; Anticancer-agent-linked phosphonates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bisphosphonates are compounds with a high affinity for bone and other calcified tissues. They inhibit tumor-induced bone destruction and the associated hypercalcemia by hindering the activity of the osteoclasts. Owing to a long biological half-life of bisphosphonates in the bone, a treatment using a prophylactic regimen seems possible. This paper summarizes preclinical studies with the bisphosphonate 3-amino-1-hydroxypropylidene-1, 1-diphosphonic acid and two methyl derivatives; S-N,N-dimethylamino-1-hydroxypropylidene-1,1-diphosphonic acid and 4-N,N-dimetyhlamino-1-hydroxybutylidene-1, 1-diphosphonic acid with respect to their bone-protecting activity in therapy as well as in prophylaxis. To find substances that are useful for the treatment of primary tumor, as well as bone metastasis, we synthesized and testedcis-diammine[nitrilotris(methylphosphonato) (2-)-O 1 ,N1]platinum(II) andcis-diammine{[bis-(phosphonatomethyl)amino]acetato(2-)-O1, N1} platinum(II), which contain both an osteotropic and an antineoplastic moiety. Experiments were carried out: (a) in the intratibial transplanted Walker carcinosarcoma 256B of the rat, which mimics osteolytic bone metastasis, and (b) in the transplantable osteosarcoma of the rat, which shows a histology and metastatic pattern similar to that found in man. These investigations indicate that it is possible to effect adjuvant therapy of bone metastases by combination of two compounds with different properties into one structure without losing the therapeutic characteristics of the parent compounds. They thus provide evidence that it may be possible to design compounds well suited for the therapeutic or prophylactic treatment of bone-related malignancies.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...