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  • 1
    Electronic Resource
    Electronic Resource
    Contact dermatitis from UV-A and UV-B filters in a patient with erythropoietic protoporphyria (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 28 (1993), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1993.tb03443.x
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  • 2
    Electronic Resource
    Electronic Resource
    Lipid composition and synthesis of HaCaT cells, an immortalized human keratinocyte line, in comparison with normal human adult keratinocytes (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 2 (1993), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Cultured keratinocytes are frequently employed for studies of epidermal lipid metabolism. Interpretation of experimental data may be complicated by donor to donor variability, the relatively short culture lifetime and variations between passages, problems thai are not encountered to the same extent with immortalized cell lines. The present study was undertaken to compare the lipid composition and synthesis of normal human adult keratinocytes (NHAK) with HaCaT cells, a long-lived. spontaneously immortalized human keratinocyte line, in relation to proliferation and differentiation. No differences between the two cell types were observed: a) in total lipid content; b) in the distribution of major lipid classes during growth at 50%, 75% and 100% confluence: c) in cultures grown at 0.6 mM calcium, at which differentiation is retarded, or at 1.6 mM calcium, at which some differentiation takes place; d) in the incorporation of [14C] acetate into cellular lipids at confluence, or e) in the fatty acid composition of major cellular lipid classes. At 100% confluence NHAK and HaCaT cells differ in their cholesterol metabolism. At all stages of growth, cholesterol synthesis in HaCaT cells is more LDL-dependent than in NHAK. Furthermore, NHAK become less LDL-dependent at confluence whereas HaCaT cells do not. HaCaT cells also revealed a significantly larger fraction of phosphatidyl-ethanolamine, -serine and -inositol at 0.6 mM calcium concentration than NHAK. These findings suggest that HaCaT cells do not differentiate as well as NHAK in vitro and may therefore serve as a model for the study of lipid metabolism in cells defective in terminal differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1993.tb00030.x
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  • 3
    Electronic Resource
    Electronic Resource
    3 cases of contact dermatitis from alkylammonium amidobenzoate (Osmaron B®) (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 27 (1992), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1992.tb03301.x
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  • 4
    Electronic Resource
    Electronic Resource
    UVA irradiation stimulates the synthesis of various matrix-metalloproteinases (MMPs) in cultured human fibroblasts (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 2 (1993), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract UVA irradiation leads to photoaging including clinical features such as wrinkle formation, reduced recoil capacity and blister formation of the skin. Besides synthesis of the extracellular matrix, its regulated degradation by various matrix-metalloproteinases (MMPs) determines the amount and the composition of the extracellular matrix within the dermis and the basement membrane of the dermo-epidermal junction. In this study we therefore ascertained whether UV irradiation could modulate the synthesis of MMPs with substrate specifities for dermal (collagen I, III, V) and basement membrane compounds (collagen IV, VII, proteoglycans, laminin) and whether synthesis of the counteracting tissue inhibitor of metalloproteinases (TIMP-I) was also affected. Following UVA irradiation specific mRNAs of MMPs 1, 2 and 3 were induced concomitantly up to 5-fold compared to mock irradiated controls. In contrast, TIMP-1 mRNA levels remained unaltered. Immunoprecipitation indicated that after UVA irradiation synthesis and secretion of MMPs 1, 2 and 3 into the supernatant increased. Taken together, our data show that UVA irradiation coordinately induced MMPs 1, 2 and 3 implying similar mechanisms in their regulatory pathways, while TIMP-I synthesis was not altered. Hence, unbalanced synthesis of MMPs potentially contributes to the dissolution of dermal and basement membrane compounds finally leading to blister formation and cutaneous photoaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1993.tb00015.x
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  • 5
    Electronic Resource
    Electronic Resource
    Gemeinsames Auftreten einer extraabdominellen Fibromatose und posttraumatischer Keloide (1994)
    Springer
    Der Hautarzt 45 (1994), S. 113-116 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Extraabdominelle Fibromatose – Desmoidtumor – Keloid – Ileus – Gardner-Syndrom ; Key words: Extraabdominal fibromatosis – Desmoid tumor – Keloid – Ileus – Gardner's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. The report deals with the clinical features of a 26-year-old man with the extraabdominal form of deep fibromatosis, which became manifest at the age of 18 years as acute ileus caused by diffuse intraabdominal fibromatous tumours. In the later course of the disease extensive fibromatous lesions developed, mainly at the skin. In addition, multiple keloids occurred after excision or after negligible traumas. The pathogenetic events of the clinical picture described may be linked to the activation of mesenchymal cells leading to the generation of either fibromatous tumours or posttraumatic keloids.
    Notes: Zusammenfassung. Vorgestellt wird ein 26jähriger Mann mit der extraabdominellen Form einer tiefen Fibromatose, die sich erstmalig im 18. Lebensjahr als akuter Ileus aufgrund ausgeprägter intraabdomineller Bindegewebstumoren manifestierte. Später traten flächenhafte, fibromatöse Bindegewebstumoren bevorzugt an der Haut auf. Neben diesen spontan entstandenen kutan und subkutan gelegenen Hauttumoren fanden sich auch Keloide nach Schnittverletzungen oder Bagatelltraumata an der Haut. Diesem Krankheitsbild liegt möglicherweise eine Aktivierung mesenchymaler Zellen zugrunde, die bei entsprechender Disposition zu fibromatösen Tumoren oder posttraumatischen Keloiden führt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050050
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  • 6
    Electronic Resource
    Electronic Resource
    Angioimmunoblastische Lymphadenopathie begleitet von M.-Duhring-ähnlichen Effloreszenzen (1994)
    Springer
    Der Hautarzt 45 (1994), S. 562-565 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Angioimmunoblastische Lymphadenopathie – Bullöse Hautveränderungen – Dermatitis herpetiformis Duhring ; Key words: Angioimmunoblastic lymphadenopathy – Bullous skin lesions – Dermatitis herpetiformis Duhring's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. A 62-year-old female patient presented with bullous, intensely itching cutaneous lesions, which clinically and histopathologically resembled dermatitis herpetiformis (Duhring's disease). Therapy with DADPS was unsuccessful. Because of associated cervical lymph node enlargement and splenomegaly, a lymph node biopsy was taken. Histopathology of a lymph node and of the bone marrow confirmed the diagnosis: angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma. Intensely pruritic associated skin eruptions are typical for this peculiar kind of lymphoma. These skin lesions are due to inflammatory cells and not to neoplastic infiltrations. This case report is the first report of AILD with bullous skin lesions to appear in the literature.
    Notes: Zusammenfassung. Kasuistik einer 62jährigen Patientin mit bullösen, stark juckenden Hautveränderungen, die histopathologisch und klinisch einer Dermatitis herpetiformis Duhring ähnelten. Eine DADPS-Therapie blieb erfolglos. Wegen einer Splenomegalie und zervikalen sowie axillären Lymphknotenvergrößerung wurde eine Lymphknotenbiopsie durchgeführt. Die Lymphknoten- und Knochenmarkshistopathologie ergaben ein T-Zellenlymphom vom AILD-Typ (angioimmunoblastische Lymphadenopathie mit Dysproteinämie). Assoziierte, von heftigem Pruritus begleitete Effloreszenzen sind charakteristisch für dieses Lymphom. Die Hautinfiltrate sind meist nicht neoplastisch, sondern bestehen aus unterschiedlich zusammengesetzten entzündlichen Infiltraten, die als immunologische Epiphänome interpretiert werden. Dies ist der erste Fall einer angioimmunoblastischen Lymphadenopathie mit bullösen Hautveränderungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050127
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  • 7
    Electronic Resource
    Electronic Resource
    Distales Ödem und Hyperhidrosis des Armes (1994)
    Springer
    Der Hautarzt 45 (1994), S. 696-701 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Sympathische Reflexdystrophie – M. Sudeck – Ganglion-stellatum-Blockade – Hyperhidrosis – Pathophysiologie ; Key words: Reflex sympathetic dystrophy – Sudeck's disease – Blockade of the stellate ganglion – Hyperhidrosis – Pathophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. Reflex sympathetic dystrophy is characterized clinically by the triad of autonomic sympathetic dysfunction, and motor and sensory disturbances of the affected extremity. Typical symptoms are distal generalized edema with cyanotic skin, pathologic function of eccrine sweat glands and diffuse dull pain. If reflex sympathetic dystrophy is not recognized an irreversible stage may be reached, with atrophic pale, cool, and anhidrotic skin, contractures and diffuse osteoporosis. The syndrome can be idiopathic but can also be precipitated by a variety of factors, including banal trauma, bone fracture, and traumatic nerve lesions. Pathophysiologically, a functional disturbance of sympathetic nerve fibres may result in a vicious circle of blood flow dysfunction, excitation of afferent nociceptors and maintenance of sympathetic dysfunction at the level of the spinal or central nervous system. In the patient presented in this paper, sympathetic dysregulation of reflex sympathetic dystrophy was cured by means of blockades of the stellate ganglion.
    Notes: Zusammenfassung. Die sympathische Reflexdystrophie ist durch eine Symptomtrias aus autonomen sympathischen, motorischen und sensiblen Störungen der betroffenen Extremität gekennzeichnet. Herausragende Symptome bestehen in einem distalen generalisierten Ödem mit livider Hautverfärbung, veränderter ekkriner Schweißdrüsenaktivität und diffusem Spontanschmerz. Wird die sympathische Reflexdystrophie nicht erkannt, droht ein irreversibles Stadium aus atrophischer, kalter und anhidrotischer Haut sowie Flexionskontrakturen und Osteoporose. Ätiologisch kommen verschiedene Faktoren wie ein banales Trauma, Fraktur, traumatische Nervenläsionen oder ein spontanes Auftreten in Betracht. Pathophysiologisch kann das Krankheitsbild mit einer funktionellen Störung des sympathischen Nervensystems erklärt werden. Es ergibt sich ein Circulus vitiosus aus Durchblutungsstörungen, Erregung afferenter Nozizeptoren und Aufrechterhaltung der sympathischen Dysfunktion auf spinaler oder zentralnervöser Ebene. Die Dysregulation der Sympathicus-Aktivität im Rahmen einer sympathischen Reflexdystrophie konnte mit Hilfe einer Serie von Ganglion-stallatum-Blockaden bei dem hier beschriebenen Patienten erfolgreich behandelt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050152
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