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  • 1
    Electronic Resource
    Electronic Resource
    Total solid-phase synthesis and prolactin-inhibiting activity of the gonadotropin-releasing hormone precursor protein and the gonadotropin-releasing hormone associated peptide (1992)
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 8799-8809 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00152a016
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Humane Anti-Mausimmunglobulin-Antikörper als Störfaktoren der TSH-Bestimmung (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 220-223 
    Details
    ISSN: 1432-1440
    Keywords: Human Anti-Mouse-Antibodies ; TSH-IRMA ; Monoclonal antibody therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monoclonal murine antibodies are increasingly used for immunotherapy and in vivo diagnostic procedures such as immunoscintigraphy. The therapeutic or diagnostic reagent however, is a foreign antigen, which may induce host reactivity. This may interfere with the therapeutic or diagnostic reagent in vivo, resulting in a loss of efficacy or the necessity to increase dosages. In addition, there is an important interference to in vitro immunoassays detecting specific antigens utilizing murine monoclonal antibodies. In the present study, sera of patients who had undergone a therapeutic trial using 140 mg of an anti-CD4 antibody, were investigated. Human anti-murine-immunoglobulin-antibodies (HAMA) were detected 2–3 weeks after treatment was started and reached maximal amounts of 0.8 μg/ml after a single and 2 μg/ml after a repeated treatment course. Parallely raised values of TSH were found in sera containing HAMAs of more than 0.3 μg/ml. Elevations of TSH levels up to 13 μU/ml were most pronounced after a repeated trial of the murine antibody and were detectable up to 20 weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646945
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of high-energy shock waves on the viable human kidney (1993)
    Springer
    Urological research 21 (1993), S. 273-277 
    Details
    ISSN: 1434-0879
    Keywords: High-energy shock waves ; Human kidney ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between September 1990 and July 1991, we treated 17 patients with renal-cell carcinoma by radical nephrectomy and two patients with urothelial carcinoma of the kidney pelvis by ureteronephrectomy. Immediately after nephrectomy, perfusion of the kidneys with cold HTK solution was performed and the organs were kept in hypothermia of 8°C. The tumor-free parenchyma of the kidneys was treated 4 h later with shock waves of different energy levels in an experimental shock-wave system (Siemens Company, Erlangen). Light microscopy and examinations by scanning laser microscopy were performed after treatment. High-energy shock waves (HESW) produce significant changes in the tubulary and blood-vessel system of the viable human kidney, depending on the energy applied. Although our model is limited by hypothermia of the explanted kidneys, the effects of shock waves on the organs can be studied. Our model is suitable for testing the effects of different lithotriptors on the human kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307710
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  • 4
    Electronic Resource
    Electronic Resource
    Formation of field discontinuities and islands in visual cortical maps (1994)
    Springer
    Biological cybernetics 70 (1994), S. 525-531 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract. The representations of visual hemifields in the extrastriate areas of various species exhibit field discontinuities and islands. We propose that these violations of retinotopy are a developmental consequence of the elongated shape of the respective cortical areas. To substantiate this claim, we investigated a model of activity-driven map formation. In agreement with observations, this model yields maps with field discontinuities if the cortical areas exceed a threshold elongation. Moreove r, within the same model island representations in the periphery and the area centralis can also be understood. A multistability of the solutions in the model gives a very simple explanation for the observed interindividual variability of maps in cats. The model leads to a prediction of the radial dependence of the areal magnification factor near field discontinuities, which could be accessible for a high precision mapping experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004220050055
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Formation of field discontinuities and islands in visual cortical maps (1994)
    Springer
    Biological cybernetics 70 (1994), S. 525-531 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract The representations of visual hemifields in the extrastriate areas of various species exhibit field discontinuities and islands. We propose that these violations of retinotopy are a developmental consequence of the elongated shape of the respective cortical areas. To substantiate this claim, we investigated a model of activity-driven map formation. In agreement with observations, this model yields maps with field discontinuities if the cortical areas exceed a threshold elongation. Moreover, within the same model island representations in the periphery and the area centralis can also be understood. A multistability of the solutions in the model gives a very simple explanation for the observed interindividual variability of maps in cats. The model leads to a prediction of the radial dependence of the areal magnification factor near field discontinuities, which could be accessible for a high precision mapping experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198805
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Proliferation of tumor spheroids after shock-wave treatment (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. 439-441 
    Details
    ISSN: 1432-1335
    Keywords: Adhesion ; DNA ; Flow cytometry ; Ki67 ; Lithotripsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Multicellular tumor spheroids (MCTS) grown from the bladder cancer cell line RT112 and from the prostate cancer cell line PCA were exposed to 200 or 800 electromagnetically generated focused ultrasound shock waves. RT112 cells showed a distinct but transient decrease in proliferation whereas the effect of PCA cells was less pronounced. Flow-cytometric measurements of DNA content and Ki67 expression revealed no significant changes in the cell cycle distribution. The capacity of RT112 cells exposed to 800 shock waves to re-grow as MCTS was markedly decreased, indicating an alteration of intercellular adhesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240146
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of bead diameter on the accuracy of two current techniques used to quantify bone ingrowth in porous-coated implants (1994)
    Springer
    Journal of materials science 5 (1994), S. 29-32 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: The effect of the bead diameter on the accuracy of two techniques used in bone ingrowth quantification, microradiography and backscattered electron imaging-scanning electron microscopy (BEI-SEM), was assessed using porous-coated implants. Two groups of seven titanium porous implants (group A: bead size 250–350 μm and group B: 500–700 μm) were implanted for 12 weeks in a canine model. After euthanasia, the same histological slides were prepared for microradiography and BEI-SEM. The percentage of bone, bone ingrowth, bone ongrowth, porosity and bone index were determined by a point counting method using images from both techniques. ANOVA and Tukey's test were used to compare the results from the different bead sizes and techniques. The results showed significant higher bone ingrowth in microradiography groups, and significant lower porosity in only the fine-bead microradiography group (group A size). Microradiography also obtained significantly higher bone ongrowth, but only for the coarse bead size group (group B). From these results it was concluded that microradiography decreases the porosity of the porous coating compared with BEI-SEM. This effect seems to be dependent on the bead diameter. The smaller the diameter, the greater the effect. Furthermore, microradiography increases bone ingrowth which seems to be affected independently of the bead diameter, becoming the most sensitive parameter to increase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00121150
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  • 8
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis joints with technetium-99m labelled specific anti-CD4− and non-specific monoclonal antibodies (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 176-180 
    Details
    ISSN: 1619-7089
    Keywords: Anti-CD4 monoclonal antibody ; Anti-carcinoembryonic antigen monoclonal antibody ; Immunoscintigraphy ; Technetium-99m labelling ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A direct comparison of the joint-imaging properties of inflammation-specific- and non-specific monoclonal antibodies (Mabs) was possible in a patient suffering from long-standing, severe rheumatoid arthritis (RA). This patient received an anti-CD4− and an anti-carcinoembryonic antigen (anti-CEA) Mab, both labelled with technetium-99m, 9 days apart from each other. The anti-CD4 Mab was superior to the isotype-matched anti-CEA Mab in imaging inflamed joints. In the knee joint, the target-to-background ratio of the synovial membrane (SM) activity in comparison to that of adjacent large vessels was 1.22 (SM/muscle 1.55) for the anti-CD4 Mab and 0.53 (SM/muscle 0.92) for the anti-CEA Mab, in both cases 4 h after injection of the immunoglobulin. Since the CD4 antigen is present on the surface of T-helper lymphocytes and macrophages infiltrating the inflamed synovial membrane, imaging with the anti-CD4 Mab may allow more specific detection of inflammatory infiltrates in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175768
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Investigation of parasympathetic and sympathetic cardiac innervation in diabetic neuropathy: Heart rate variation versus meta-iodo-benzylguanidine measured by single photon emission computed tomography (1994)
    Springer
    Clinical autonomic research 4 (1994), S. 117-123 
    Details
    ISSN: 1619-1560
    Keywords: Autonomic diabetic neuropathy ; Heart rate variation ; MIBG-SPECT ; Thermal thresholds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In diabetic neuropathy disturbed autonomic cardiac innervation is associated with shortened life expectancy. Sympathetic dysfunction is likely to play a role in cases of cardiac death. The quantitative uptake of the radiopharmaceutical iodine-123-meta-iodo-benzylguanidine (MIBG) can be measured by single photon emission computed tomography (SPECT). It is an index of the functional integrity of sympathetic neurones in the heart. The respiratory heart rate variation—as assessed by a computerized device—reflects mainly parasympathetic cardiac innervation. In 25 diabetic patients and 19 healthy subjects MIBG-SPECT and heart rate variation tests were carried out. MIBG scans in all normal subjects showed homogeneous uptake of activity. In 12 out of 25 patients at least two heart rate variation tests were abnormal. MIBG-SPECT was more sensitive (abnormal in 17 out of 25). The lack of correlation between MIBG-SPECT results and spectral analysis of heart rate variation suggest that spectral analysis alone should not be regarded as an indicator of sympathetic cardiac innervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01845775
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Bone scan and red blood cell scan in a patient with epidermal naevus syndrome (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 369-371 
    Details
    ISSN: 1619-7089
    Keywords: Bone scan ; Red blood cell scan ; Epidermal naevus syndrome ; Haemangiomas of bone ; Hypophosphataemic osteomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A bone scan and red blood cell scan in the rare epidermal naevus syndrome, associated with multiple haemangiomas of the bone and hypophosphataemic osteomalacia in a 20-year-old man are reported. The typical pattern of osteomalacia on the bone scan was associated with lesions of increased bone metabolism in the peripheral bones. The haemangiomas did not pool labelled red blood cells. Thus, the bone scan seems to be suitable for diagnosing the complete extent of haemangiomas in bone, but they could not be specifically proven by red blood cell pooling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01268029
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