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  • 1
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 723 (1994), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 731 (1994), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 43 (1994), S. 750-752 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter: Tiefe Hypothermie – Diabetisches Koma – Hämofiltration – Reanimation ; Key words: Accidental hypothermia – Diabetic coma – Haemofiltration – Resuscitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. A 41-year-old woman with severe juvenile diabetes mellitus suffered from profund hypothermia after loss of thermoregulation in diabetic ketoacidosis. She was found unconscious, without measurable blood pressure; the electrocardiogram (ECG) showed bradycardia of 30/min and the rectal temperature was 23.7 °C. The patient received mechanical ventilation, fluid therapy, warmed gastric lavage, and, unfortunately, inotropic medication. She was transferred to a department of cardiac surgery in order to continue the therapy with cardiopulmonary bypass (CPB). On arrival, the patient had a rectal temperature of 27.3 °C, the ECG showed an absolute arrhythmia with a frequency of 70/min, and the blood pressure was 63/43 mm Hg. We decided to use a rapidly available but not highly invasive venovenous hemofiltration technique for slowly rewarming the patient. Vascular access was achieved by percutaneous femoral vein cannulation with a Shaldon catheter. The hemofiltration system (Gambro AK-10, Gambro AB, Sweden) was instituted with a blood flow rate of 200 ml/min. The hemofiltration monitor controls the pumps for filtering and substituting fluid volumes and allows the infusion solutions to be heated up to 40 °C. Sinus rhythm resumed without antiarrhythmic medications at a temperature of 29.5 °C, and within 8 h the patient was rewarmed to 35.5 °C. After treatment of the adult respiratory distress syndrome caused by pneumonia, she was discharged from the intensive care unit to complete treatment with no evidence of any permanent organ damage. We conclude that hemofiltration may be the method of choice for rewarming deeply hypothermic patients when their circulation is preserved. Under these circumstances, it is preferable to external rewarming techniques, as it avoids the disadvantages of temperature afterdrop and rewarming shock. Rewarming rates of 1.5 °C/h seem to be adequate. Hemofiltration systems are more widespread, less invasive, and easier to handle compared to CPB techniques, which should be preferred in situations of prolonged unsuccessful cardiopulmonary resuscitation with cardiac arrest and deep core temperatures.
    Notes: Zusammenfassung. Eine 41jährige Diabetikerin wurde im ketoazidotischen Koma mit einer Körpertemperatur von rektal 23,7 °C in ihrer Wohnung aufgefunden. Nach notärztlicher Primärversorgung und Kliniktransfer erfolgte die Verlegung der Patientin in eine herzchirurgische Klinik, um die Behandlung unter Einsatz eines kardiopulmonalen Bypasses fortsetzen zu können. Die Patientin wurde dort jedoch, bei zwischenzeitlich stabilerer Kreislauffunktion und einer Rektaltemperatur von 27,3 °C, über einen perkutan in die Vena femoralis plazierten Shaldonkatheter an ein extrakorporales Hämofiltrationssystem angeschlossen. Nach achtstündiger, komplikationsfreier veno-venöser Hämofiltration mit erwärmten Substitutionslösungen betrug die Kerntemperatur 35,5 °C. Schnelle, über 1,5 °C/h liegende Erwärmungsphasen wurden vermieden, da sie den zerebralen Stoffwechsel ungünstig beeinflussen. Die Patientin konnte nach Behandlung eines ARDS bei Pneumonie, ohne Hinweise auf bleibende Organschäden, in eine Anschlußbehandlung verlegt werden. Wir folgern, daß bei hypothermen Patienten mit erhaltener Kreislauffunktion die kontinuierliche veno-venöse Hämofiltration ein wenig invasives, technisch einfaches, effektives und schonendes Wiedererwärmungsverfahren ist. Seine Anwendung kann eine vorteilhafte Alternative zu dem wesentlich aufwendigeren Verfahren eines kardiopulmonalen Bypasses sein. Seine Indikationen können somit auf Patienten mit einem Kreislaufstillstand bei sehr tiefen Körpertemperaturen oder einer längeren erfolglosen kardiopulmonalen Reanimation präzisiert werden.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1939
    Keywords: Air pollution ; Acid rain ; Photosynthesis ; Nutrition ; Picea abies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Photosynthetic rates and nutrient contents of spruce needles were measured in a region with high levels of air pollution in NE Bavaria, Germany (FRG), and compared to spruce grown under clean air conditions at Craigieburn, in the South Island of New Zealand (NZ). The absolute rates of CO2 uptake, the slope of the CO2 response curve at 240 μl l−1 internal CO2 concentration, and the change of photosynthetic rates with needle age at ambient and saturated CO2 concentrations were virtually identical at both measuring sites. These results confirm an earlier conclusion, that there is no long-term effect of atmospheric pollutants directly on photosynthetic CO2 uptake rates with persistent exposure at the FRG site to high levels of anthropogenic air pollution. Photosynthetic capacity at saturating CO2 concentration was three times higher in the NZ spruce. Needles with high photosynthetic capacity in NZ had lower nitrogen and higher calcium concentrations per unit dry weight but higher concentrations of nitrogen, phosphorus, potassium, magnesium and calcium per unit leaf area, and twice the specific leaf weight.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 39 (1990), S. S9 
    ISSN: 1432-1041
    Keywords: Cardiac microcirculation ; left ventricular hypertrophy ; myocardial ischemia ; stunned myocardium ; leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary I. Myocardial hypertrophy, for instance in patients with hypertensive heart disease, is characterized by a reduction of coronary vascular reserve, even in the presence of normal coronary arteries. In hypertensive animals, on the microcirculatory level functional changes can be observed before the onset of any structural rarefications. In 10 rats with renal hypertension and pressure-induced left ventricular hypertrophy (LVH), the microcirulation of the left ventricular myocardium was studied using in vivo fluorescence microscopy and morphometric analysis. Renal hypertension was provoked by clipping of the left renal artery. After 8 weeks, systolic blood pressure in LVH rats averaged 172 ± 8 mm Hg, compared to 91 ± 2 mmHg in 10 normotensive (NT) rats. In LVH rats, distances of plasma-perfused capillaries were significantly increased (NT = 17.7; LVH = 20 μm;p 〈 0.001). Volume density, surface density, and length density of capillaries in LVH rats were reduced by 20% compared to NT rats. Capillary red cell content as measured by the ratio of capillaries filled with red cells to those containing plasma alone (Q) in LVH animals exceeded that in NT rats (LVH: Q = 0.83 ± 0.04; NT Q = 0.77 ± 0.04;p 〈 0.025). During hypoxia (H, 5% 02) capillary red cell recruitment in LVH rats (Q: control c = 0.83; H = 0.95) was diminished by 33% as compared to NT rats (Q: c = 0.77; H = 0.95). Thus, in addition to the decreased capillary density, the reduction of capillary red cell recruitment may be responsible for chest pain in patients with LVH and normal coronary arteries. 2. In 11 rats, the microcirculation of the repeatedly ischemic (stunned) left ventricular myocardium (SM) was studied using in vivo fluorescence microscopy. Stunning was provoked by 6 subsequent 10 minute ligations of the left anterior descending coronary artery, each of them followed by a 20 min reperfusion period. In the SM showing hypokinetic wall motion mean capillary blood flow velocity was markedly reduced (control c =1312; SM = 694 μm/sec;p 〈 0.001): myocardial blood flow (hydrogen clearance) in the SM dropped by 55%. In SM, leukocytes often appeared in slow-flow capillaries plugging capillary branches: the percentage of capillaries and postcapillary venules with adherent leukocytes was markedly increased (c = 3%; SM = 68%). In close link to leukocyte adherence, a rise of microvascular permeability was documented by extravascular clouds of fluorescent dextran. The ratio of capillaries filled with red cells to those containing plasma alone was diminished in SM (c = 0.77; SM = 0.65;p 〈 0.001). In the SM there are microcirculatory disturbances which occur before the onset of detectable structural alterations of both the microvasculature and the myocyte.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-6881
    Keywords: Mammalian endoplasmic reticulum ; prepromelittin ; prepropeptide GLa ; preprocecropin A ; M13 procoat protein ; protein transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract There are at least two different mechanisms for the transport of secretory proteins into the mammalian endoplasmic reticulum. Both mechanisms depend on the presence of a signal peptide on the respective precursor protein and involve a signal peptide receptor on the cis-side and signal peptidase on the trans-side of the membrane. Furthermore, both mechanisms involve a membrane component with a cytoplasmically exposed sulfhydryl. The decisive feature of the precursor protein with respect to which of the two mechanisms is used is the chain length of the polypeptide. The critical size seems to be around 70 amino acid residues (including the signal peptide). The one mechanism is used by precursor proteins larger than about 70 amino acid residues and involves two cytosolic ribonucleoparticles and their receptors on the microsomal surface. The other one is used by small precursor proteins and relies on the mature part within the precursor molecule and a cytosolic ATPase.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 89 (1992), S. 21-27 
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The exchange splittings of the 3s core levels are analyzed for a number of manganese, iron and cobalt compounds. It is found that in MnF2, MnCl2, FeF3, FeF2, FeCl2 and CoF2 the lowest energy state after photoemission has the samed-electron count as the ground state. In CoCl2 the mixing of thed 7L and thed 8L−1 is very strong.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 7 (1993), S. 183-185 
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Laser-induced mass spectra and UV spectra of dibenzodioxin, dibenzofuran, and two isomers of dichlorodibenzodioxin measured by means of resonance-enhanced multiphoton ionization in a supersonic molecular beam are presented. The UV spectra show sharp bands and large wavelength shifts both being specific to the number and position of the chlorine atoms. The mass spectra are free of fragments. Therefore the prerequisites for isomer selective ionization and detection of these substances are fulfilled. This encourages further work on polychlorinated dibenzodioxins and dibenzofurans.
    Type of Medium: Electronic Resource
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