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  • 1
    Electronic Resource
    Electronic Resource
    Histochemical observations of lectin-binding in experimental carcinomas in mouse submandibular glands (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peroxidase-conjugated lectins were used for the histochemical detection of carbohydrates in experimental carcinomas of mouse submandibular glands. Induced carcinomas, 43 lesions from 25 cases, were examined histoehemically with galactose-binding leetins (PNA and RCA-I), N-acetyl-galactosamine-binding leetins (DBA and SBA), a fucosc-binding lectin(UEA-l), and a N-acetyl-glucosamine-binding lectin (WGA). In non- or slightly keratinized squamous-cell carcinomas, the lectin binding of PNA, RCA-1, DBA, SBA. and WGA was weak in tumor epithelia, and UEA-1 binding was slight. In highly keratinized squamous-cell carcinomas, lectin binding was increased in tumor epithelia, but no reaction was noted in completely keratinized regions. Desquamated materials in lumens of tumors gave an intense stain with leetins. Stromal connective tissue, including collagen fibers and basement membranes stained intensely. Lectin binding to submandibular carcinomas was different from binding to granular convoluted tubules and the striated ducts of the normal submandibular gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01460.x
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  • 2
    Electronic Resource
    Electronic Resource
    Histopathologic studies of DMBA-induced mouse submandibular-gland tumors with or without cryoprobe treatment (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Histopathologic observations of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced tumors in the mouse submandibular glands arc reported using cryoprobe treatment. The experimental animals were divided into 2 groups; one received a carcinogen injection into the normal submandibular gland, and the oilier was injected with DMBA on the Mill day following cryosurgery of the gland using a 60°C cryoprobe. Pathologic findings were classified as premalignant lesions or squamous-cell carcinomas with varying degrees of keratinization, fibrosarcoma and mixed carcinoma. There was also one case each of malignant pleomorphic adenoma and cystic adenoma. Tumor incidence was nearly the same in the 2 groups. Most of the carcinomas and sarcomas in the submandibular gland were induced during the 12th and 17th weeks. DMBA application during the proliferating stage which followed the cryosurgery did not enhance epithelial-tumor induction. During submandibular gland carcinogenesis, alterations in the granular convoluted tubule cells suggests they were the initial target cells undergoing malignant transformation. Squamous-cell carcinomas with varying degrees of keratinization were induced following squamous metaplasia in duct-like structures or multicystic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01442.x
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  • 3
    Electronic Resource
    Electronic Resource
    Lectin-binding in premalignant lesions during submandibular gland carcinogenesis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Complex carbohydrates in premalignant lesions of mouse submandibular gland tumors were examined by the lectin-peroxidase conjugate method. Peroxidase-conjugated lectins of PNA, RCA-1, DBA, SBA, UEA-1 and WGA were used to detect specific sugar residues of complex carbohydrates in premalignant lesions during experimental carcinogenesis. Marked reduction of PNA and SBA bindings occurred in duct-like structures and cystic lesions which were transformed from granular convoluted tubule cells. Premalignant lesions bound slightly to PNA, RCA-1, DBA, SBA and WGA and manifested increased UEA-1 binding. Squamous metaplastic epithelia of premalignant lesions manifested increased binding to PNA, RCA-1 and SBA as compared to those of duct-like structure and cystic epithelia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01451.x
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  • 4
    Electronic Resource
    Electronic Resource
    Histochemical studies on Concanavalin A-binding in experimental carcinoma of the mouse submandibular gland (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The lectin, Concanavalin A(Con A) has been used to localize specific sugar residues (D-glucose, D-mannose and D-fructose) in premalignant lesions and squamous-cell carcinomas induced following cryosurgery of the mouse submandibular gland. The original Con A-horseradish peroxidase (HRP) technique as well as its combination with periodate oxidation and subsequent reduction by borohydrate were used to compare the epithelial elements during submandibular gland carcinogenesis. Granules in the granular convoluted tubule cells which were weakly reactive to the Con A-HRP method were not present in the premalignant duct like structures. The epithelium of premalignant lesions, duct-like structures, multicystic lesions, and squamous-cell carcinomas were positive for the cell-surface and intercellular substances; and basement membranes and stromal fibers were also positive. The results indicated that throughout malignant transformation of the ductal segments, premalignant epithelia lost Con A-HRP-staining granules and that Con A-binding patterns in induced squamous-cell carcinomas were similar to those found in squamous-cell epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01443.x
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  • 5
    Electronic Resource
    Electronic Resource
    Studies on saliva in ODU plaque-susceptible rats having experimental gingivitis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 19 (1984), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Saliva was collected from the submandibular, parotid, and sublingual glands at to compare the amount of saliva between ODU plaque-susceptible (Sus) and plaque-resistant (Res) rats. The amount of saliva secreted was less in the Sus rats than in the Res rats. This difference was mainly due to a decrease in salivation from the submandibular glands, which resulted from the decrease in the weight of these glands. This reduction in salivation may be associated with the rapid rate of plaque formation seen around the mandibular teeth of these animals and the development of periodontal diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1984.tb01192.x
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  • 6
    Electronic Resource
    Electronic Resource
    IMMUNOHISTOCHEMICAL STUDIES ON α-FETOPROTEIN- AND ALBUMIN-CONTAINING CELLS IN THE LIVER DURING ONTOGENESIS AND EARLY STAGE OF 3′-ME-DAB HEPATOCARCINOGENESIS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 417 (1983), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1983.tb32863.x
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  • 7
    Electronic Resource
    Electronic Resource
    Histochemical studies of lectin binding patterns in keratinized lesions, including malignancy (1984)
    Springer
    Virchows Archiv 402 (1984), S. 337-351 
    Details
    ISSN: 1432-2307
    Keywords: Lectin ; Oral leukoplakia ; Paget's disease ; Keratoacanthoma ; Condyloma acuminatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histochemical detection of lectin binding was carried out using the HRP-conjugated lectin method in hyperkeratinized lesions including leukoplakia,carcinoma in situ, Paget's disease, keratoacanthoma, and condyloma acuminatum. The lectins used for demonstrating sugar residues were: Con A (hexose), PNA and RCA-1 (Gal), DBA and SBA (GalNAc), UEA-1 (Fuc), and WGA (GlcNAc). Lectin binding in normal squamous epithelium showed regional distribution patterns of keratinized, spinous and basal layer types. Histo-chemical localization of lectin binding was generally at the cellular surface and in the intercellular substance and sometimes in the cytoplasm of normal epithelial cells. Dysplastic cells or carcinoma cell, in contrast, displayed a loss of cellular surface and intercellular staining. Paget's cells were devoid of lectin staining. In keratoacanthoma and condyloma specimens, spinous cells, which were PAS-positive, showed an intense PA/Con A-HRP staining and moderate binding by other lectins, which was somewhat decreased when compared with that in the surrounding intact epithelium. The cytochemical distribution of epithelial lectin binding might be indicative of the expression of normal stratification and keratinocytic differentiation, and the disappearance of this typical epithelial pattern may suggest severe dysplasia and malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00734632
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  • 8
    Electronic Resource
    Electronic Resource
    Antidiuretic and thermogenic effects of intracerebroventricular prostaglandin H2 in ethanol-anaesthetized rats (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 209-211 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary When PGH2 was administered intracerebroventricularly at doses of 5 and 15 nmoles in ethanol-anaesthetized rats, alcohol diuresis was inhibited and rectal temperature, blood pressure and heart rate were all significantly increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953736
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular basis of ornithine transcarbamylase deficiency lacking enzyme protein (1984)
    Springer
    Journal of inherited metabolic disease 7 (1984), S. 2-8 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report an ornithine transcarbamylase(OTC)-deficient male patient who had no detectable immunoreactive materials but did have active mRNA for OTC-related protein. The total absence of OTC activity in the liver of the patient was caused by a complete lack of immunoreactive material, as determined by Ouchterlony double immunodiffusion, single radial immunodiffusion, and sodium dodecylsulphate-polyacrylamide gel electrophoresis of immunoprecipitate and of liver homogenate. However, mRNA coding for the precursor of OTC was clearly detected in autopsy specimens of the patient's liver as well as of controls in a cell-free translation system consisting of rabbit reticulocyte lysates and [35S]methionine. The labelled precursor of OTC synthesizedin vitro with mRNA from the patient could be transported into rat liver and kidney mitochondria and processed to form a protein with a mulecular weight indistinguishable from mature OTC, suggesting that there was no defect in the protein structure necessary for its transport into mitochondria. These results suggest that the primary defect of the OTC deficiency was located in the structural gene and that the labile OTC-related protein, after being synthesized with its mRNA, was degraded too rapidly to be detected by the method used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805609
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  • 10
    Electronic Resource
    Electronic Resource
    Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives (1980)
    Springer
    Journal of cancer research and clinical oncology 98 (1980), S. 9-13 
    Details
    ISSN: 1432-1335
    Keywords: ODC ; Phorbol ester ; Tumor promoter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Measurements were made of induction of ornithine decarboxylase activity after painting mouse skin with 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate and its two epimeric 4-deoxy-analogs, 12-O-hexadecanoyl-4-deoxy-16-hydroxyphorbol-13-acetate and 12-O-hexadecanoyl-4-deoxy-4α-16-hydroxyphorbol-13-acetate. The inductive activities of HHPA and 4-deoxy-HHPA were similar, but 4-deoxy-4α-HHPA had no inductive activity. These findings on natural phorbol esters confirm that both the 4β-hydrogen and the 4β-hydroxyl in phorbol esters are essential for ODC-inducing activity. The interactions of 4-deoxy-HHPA and 4-deoxy-4α-HHPA with a possible receptor are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413172
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