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  • 1
    ISSN: 1432-1440
    Keywords: Critical care ; Severe non-thyroidal illness ; Free fatty acids ; Thyroid function tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary As a contribution to the question if the elevated concentrations of free fatty acids in sera of critically ill patients described in literature play a role in the decrease of thyroid hormone levels in these patients, serum levels of the important free fatty acids were measured in 31 patients of our intensive care unit in the course of their disease using gas chromatography. After admission to the ward, only palmitoleic acid was significantly increased compared with 174 control persons, arachidonic acid was not different from the controls, palmitic, stearic, linoleic and linolenic acid were significantly decreased. In the course of the disease, no relevant changes were observed. The 21 patients not surviving their disease showed significantly lowered levels of palmitic, stearic and linoleic acid before death compared with the surviving patients at the end of the observation period. The hypothetical role of single free fatty acids as inhibitors of the binding of thyroid hormones to their transport proteines must be questioned because of the results.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 64 (1986), S. 8-14 
    ISSN: 1432-1440
    Keywords: Goiter, exophthalmic, diagnosis ; Goiter, exophthalmic, immunology ; Goiter, exophthalmic, therapy ; Thyrotropin binding inhibiting antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 223 patients suffering from Graves' disease, TSH receptor autoantibodies in serum were measured using the commercially available TRAK assay (Henning, Berlin). Of 53 patients examined before treatment, 50 (94%) were TRAK-positive. During drug therapy the number of positive titers decreased. Of 38 patients examined after a therapy course for the first time, only two (5.3%) were positive. Evaluation of antibody status after all three forms of treatment (drugs, surgery, radioiodine) in 146 patients showed that of 33 patients with persistently positive titers only nine relapsed. Of the 24 patients out of this group without relapse, 15 had operative or radioiodine treatment. The 113 patients becoming or remaining TRAK-negative after treatment showed 12 relapses, in all these cases relapse was accompanied or announced by conversion to positive TRAK values. The high sensitivity and specificity of the assay (in a control group of 40 patients with autonomous adenoma no positive TRAK was seen) allow to use the test for discrimination between Graves' disease and disseminated autonomy of the thyroid in patients presenting with diffuse hyperthyroidism. Thus, by helping to establish an exact diagnosis, TRAK could become important for therapy planning. Concerning relapse prediction, our data are less promising since only 39% of patients with persistently positive TRAK titers relapsed. TRAK is not a reliable indicator of relapse risk especially in patients operated or treated with radioiodine. On the other hand, 10% of patients showing negative titers after treatment also relapsed, all turning to positive TRAK values at the same time.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 20 (1950), S. 27-37 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 20 (1950), S. 361-364 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 20 (1950), S. 58-59 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die komplementbedingte Opsonierungsaktivität (CMOA) in Intraabdominalexsudaten, gewonnen während der Laparotomie von Peritonitispatienten, wurdein vitro an einem Phagozytosemodell untersucht. Es zeigte sich, daß infektiöse Intraabdominalexsudate die Abtötung vonEscherichia coli O1 durch polymorphkernige Leukozyten kaum fördern. Bakterien, mittels Differentialzentrifugation aus infizierten Exsudaten gewonnen, wiesen nur zu einem geringen Teil C3 auf ihrer Oberfläche auf. Diese Organismen wurdenin vivo nicht optimal opsoniert, während siein vitro nach kurzer Inkubationszeit in normalem Humanserum mit C3 vollständig beladen werden konnten. Der geringe Gehalt an C3 im Peritoneum kommt einer Verringerung von Komplement im Blut gleich. Dementsprechend war die CMOA bei Septikämien, bedingt durch gramnegative Organismen, extrem niedrig. Die Ergebnisse lassen vermuten, daß die hohe Anfälligkeit des Peritoneums für Infektionen durch Keime der Darmflora zum Teil mit dem niedrigen Gehalt an Komplement erklärt werden kann, der eine ausreichende Opsonierung der Bakterien nicht gewährleistet.
    Notes: Summary The complement-mediated opsonic activity (CMOA) in intra-abdominal exudates collected during laparotomy from peritonitis patients was examined by anin vitro phagocytic bactericidal assay. It was found that infected intra-abdominal exudates barely promoted detectable killing ofEscherichia coli 01 by polymorphonuclear leukocytes. Only the minority of bacteria recovered by differential centrifugation from the infected exudates had C3 on their surfaces. Such bacteria were not optimally opsonizedin vivo, whereas they became fully coated with C3 during a brief incubationin vitro in normal human serum. The low level of CMOA in the peritoneal fluid paralleled a depletion of complement in the peripheral blood. Thus, in cases complicated by sepsis with gram-negative bacteria, the CMOA in the blood was extremely low. These data suggest that the high susceptibility of the peritoneum to infection by gut flora, despite the normal phagocytic response, may be partly explained by the low local level of functional complement which is inadequate for optimal opsonization of the bacteria.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-2451
    Keywords: Nitroblue-tetrazolium test ; Nylon column dye test ; Function of granulocytes ; Postoperative infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die klinische Anwendung eines einfachen Nitroblau-Tetrazolium (NBT)-Tests zur Überprüfung der „Killing-Funktion” von Granulocyten bei Patienten mit unterschiedlichen operativen Eingriffen wird beschrieben. Bereits präoperativ beobachtete Abweichungen der NBT-Reduktionskapazität von Granulocyten gegenüber zugrundegelegten Normwerten korrelieren dabei mit dem Auftreten postoperativ infektiöser Komplikationen. Den Befunden zufolge könnte diesem NBT-Test als „grobem Indikator” der Granulocytenfunktion eine Prädiktabilität für Risikopatienten zukommen.
    Notes: Summary The clinical application of a simple quantitative NBT-test to investigate the „killing function” of granulocytes in surgical patients with various underlying diseases is described. In this test preoperative patients showing a decreased NBT-reduction in their leucocytes always developed infectious complications after surgery. Taken together, these results indicate that the NBT-test could be used as a „simple indicator” of the granulocyte function in respect to the predictability for patients with high risk of infection.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 373 (1988), S. 313-317 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 365 (1985), S. 25-35 
    ISSN: 1435-2451
    Keywords: Small intestine ; Small intestinal tumors ; Gastrointestinal tumors ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer retrospektiven Analyse wurden 91 Patienten aus dem Beobachtungszeitraum 1965–1983 mit primären Tumoren des Dünndarms nachuntersucht. In 33% konnte präoperativ die richtige Diagnose gestellt werden. Die Anamnesezeit von 6,3 Monaten hat ihre Ursache im Fehlen von spezifischen Leitsymptomen. Ein Großteil der Patienten mußte aus vitaler Indikation ohne genaue präoperative Abklärung laparotomiert werden. Die gutartigen Tumoren (n = 34)konnten ohne Letalität radikal entfernt werden. 62,5% der malignen Tumoren wurden radikal, 37,5% palliativ reseziert. 10 Patienten (8 davon palliativ operiert) verstarben perioperativ. Das Adenocarcinom einerseits und das Adenom andererseits stellten die wichtigsten histologischen Diagnosen. Die 5-Jahres-Überlebensrate für radikal operierte Patienten beträgt 60% beim Carcinoid, 25% beim Sarkom, 17,5% beim Carcinom und 20% beim primär der palliativen Gruppe zugeordneten Lymphom. Die durchschnittliche überlebenszeit der radikal Operierten beträgt 44,12 Monate, der palliativen 13,37 Monate. 18 Patienten (51,44%) der radikal Operierten sind noch am Leben, die durchschnittliche Nachbeobachtungszeit beträgt 5 Jahre. Neben der Seltenheit der primären Dünndarmtumoren wird über diagnostische Methoden und deren Bedeutung, über Symptomatik, operative Taktik, postoperative Komplikationen und Reoperationsfrequenz sowie die Langzeitprognose in Abhängigkeit von verschiedenen Parametern berichtet. Die Wichtigkeit der konsequenten Durchführung einer gastroenterologischen Untersuchungskette bei Patienten mit abdomineller Symptomatik und entsprechendem Tumorverdacht sowie die Bedeutung der Explorativlaparotomie als oftmals entscheidender diagnostischer und auch therapeutischer Eingriff sowie die unbedingte Forderung nach operativer Radikalität werden unterstrichen.
    Notes: Summary Between 1965 and 1983 91 patients suffering from primary tumors of the small intestine underwent surgical treatment. These patients comprise 1.24% of the total number having gastrointestinal tumors in that period. In 33% exact preoperative diagnosis was set. The delay in establishing diagnosis (6.3 months) was due to nonspecific symptoms. The majority of patients underwent operation because of vital indication without former specific investigation. Benign tumors could be resected radically without lethality. Curative resection could be performed in 62.5% and palliative resection in 37.5% of malignant lesions. Surgical lethality was 17.8%. The most common histologic type were the adenocarcinoma at one side and the adenoma at the other. The 5-year-survival-rate for curatively resected patients ranged from 60% for carcinoids, 25% for carcinomas up to 20% for lymphomas. The mean survival rate for patients who underwent curative resection was 44.12 months, for those with palliative treatment 13.37 months. 18 patients, 51.4% of the curatively treated group, are still alive, mean follow-up time being 5 years. Rareness, challenge in diagnosis, surgical procedures, postoperative complications, reoperation frequency and long-term prognosis seen from various points of view are discussed. Our study emphasizes the importance of thorough gastroenterologic investigation of patients with tumor-suspective abdominal symptoms and the eminence of explorative laparotomy as final diagnostic and therapeutic step as well as the postulation for ultimate surgical radicality.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 543 (1986), S. 152-160 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Crystal Structure of [Co(NH3)6]2P4O13 7·5H2OSingle crystals of [Co(NH3)6]P4O13 · 5 H2O were obtained by diffusion controlled growth. To this end sodium polytetraphosphate was prepared by column chromatography and allowed to react with [Co(NH3)6]Cl3. The compound [Co(NH3)6]2P4O13 · 5 H2O contains the novel isolated polytetraphosphate anion.The expected systematic variation in bond length in the P—O—P bridges of the poly tetraphosphate anion was verified. The conformation of the anion is discussed.
    Notes: Mittels präparativer Säulen-Chromatographie wurde Natrium-catena-Tetraphosphat isoliert und nach Umsetzung mit [Co(NH3)6]Cl3 in diffusionskontrolliertem Wachstum Einkristalle von [Co(NH3)6]2P4O13 · 5 H2O gezogen. In dieser Verbindung sind erstmals „isolierte“ catena-Tetraphosphat-Anionen vermessen worden. Das catena-Phosphat kristallisiert in der Raumgruppe P21/c mit a = 1547,8(8) pm; b = 1263,6(8) pm; c = 1451,1(8) pm; β = 112,23(4)°; Z = 4; MoKα; 3440 unabhängige Reflexe; Rw = 5,19% (Vierkreisdiffraktometerdaten, Wasserstofflagen nicht bestimmt).Das catena-Tetraphosphat-Anion weist die vermuteten systematischen Abstandsschwankungen innerhalb der P—O—P—Brücken auf. Die Konformation des Anions wird diskutiert.The polyphosphate crystallizes in the space group P21/c with a = 1547.8(8) pm; b = 1263.6(8) pm; c = 1451.1(8) pm; β = 112.23(4)° Z = 4; MoKα; 3440 unique reflections; Rw = 5,19%. (4-circle diffractometer data, hydrogen positions not located).
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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