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  • 1985-1989  (7)
  • 1870-1879  (5)
  • Inorganic Chemistry  (9)
  • D600  (3)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    D600 prolongs inactivation of the contractile system in frog twitch fibres (1987)
    Springer
    Pflügers Archiv 410 (1987), S. 75-82 
    Details
    ISSN: 1432-2013
    Keywords: Twitch fibre ; K-contracture ; Inactivation ; D600
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (1) Single twitch fibres were dissected from tibialis muscles ofRana temporaria and used to study the effect of D600 (gallopamil) on potassium-induced contractures. (2) 95 mM K-Ringer's was applied for 8–15 s at intervals of generally 2.5–5 min; at temperatures of 6–8°C and in the absence of D600 the amplitude of the contractures remained fairly constant. After pretreatment with D600 (30 μM) a single (conditioning) K-contracture was sufficient to ‘paralyze’ the fibres (cf. Eisenberg et al. 1983). (3) Complete paralysis could also be achieved at 18–20°C. In three fibres a single conditioning K-application was sufficient; in two more fibres two or three conditioning K-applications were required. (4) D600-paralysis could not only be achieved with high K-concentrations but also by conditioning with subor suprathreshold K-concentrations (20–40 mM); the duration of the conditioning periods required to induce complete paralysis was approximately the same before and after D600-treatment. (5) Contractures were partially abolished by application of 20–40 mM K-Ringer's for short conditioning periods; after D600-treatment the degree of contracture loss was similar. (6) At low temperature the state of partial or complete paralysis induced by subthreshold K-concentrations and D600 was maintained for long periods of time. (7) The presence of 10 mM Ca2+ did not protect the fibres from being paralyzed by treatment with D600 and high K-Ringer's at low temperature; however, more than one conditioning K-application was required. (8) Resting and action potentials of paralyzed fibres were not significantly different from control values. However, endplate potentials were reduced in size, and failure of neuromuscular transmission was observed in some of these fibres. (9) It is concluded that D600 prolongs the state of inactivation of the contractile mechanism, while the development of inactivation does not seem to be markedly affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581899
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of D600 on potassium contractures of slow muscle fibres ofRana temporaria (1988)
    Springer
    Pflügers Archiv 412 (1988), S. 390-396 
    Details
    ISSN: 1432-2013
    Keywords: Slow fibre ; K-Contracture ; D600 ; Inactivation ; Repriming
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (1) The effect of 30 μM D600 on the amplitude and time course of isometric contractures was studied in single slow fibres ofRana temporaria. (2) D600 only slightly reduced the amplitude of contractures evoked with 30 or 95 mM K-Ringer's. Maintenance of tension was strongly impaired by D600 only during exposure to 95 mM K. The caffeine contracture was not affected. (3) Addition of 10 mM Ca2+ or other divalent cations to the medium strongly counteracted the effect of D600 on maintained tension. The order of efficiency was Ca2+=Ni2+〉Co2+〉Mn2+〉Mg2+. (4) During 2 min exposure to 95 mM K-Ringer's the slow fibres inactivated to a variable degree; recovery from inactivation in normal Ringer's proceeded with a half time of the order of 1 min, while in the presence of D600 recovery was prolonged 3.3 to 27 times. (5) It is concluded that the effect of D600 on the contractile behaviour of slow fibres fromRana temporaria is predominantly due to a prolongation of the inactivated state. It is suggested that D600 binds to a site at the outer membrane surface which also binds divalent cations and determines the degree of contractile inactivation during exposure to potassium. Blocking of Ca2+ channels is unlikely to be the mechanism of this D600-effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907557
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  • 3
    Electronic Resource
    Electronic Resource
    Competitive action of divalent cations and D600 in frog slow muscle fibers (1989)
    Springer
    The journal of membrane biology 112 (1989), S. 185-192 
    Details
    ISSN: 1432-1424
    Keywords: slow fiber ; K contracture ; D600 ; divalent cations ; competitive binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Single, slow muscle fibers fromRana temporaria were equilibrated in normal Ringer's. 95 mmol/liter K1-solution containing various concentrations of Ca2+, Ni2+, Mn2 or Mg2+ was applied, and the ensuing contractures were recorded isometrically. While peak tension (F max) was little affected, maintained tension (measured 1 min after onset of contracture) strongly depended on the concentration and species of divalent cations. Tension was maintained at its peak value in the presence of all species of divalent cations provided their concentrations were adequately increased. Dose-response curves were hyperbolic: Lineweaver-Burk plots revealed straight lines with different slopes intersecting near 1/F max, and indicating the following order of efficiency: Ni2+〉Ca2+〉Mn2+〉〉Mg2+. Hill plots for these cations resulted in straight lines with slopes near 1. Qualitatively similar relationships were obtained with contracture solutions containing D6000 (3–12 μmol/liter). However, under these conditions higher concentrations of Ca2+ or Ni2+ were required in order to fully maintain tension. After a step concentration change in the medium during contracture, the effects of Ca2+ or D600 were detectable only after a delay of 9 and 18 sec, respectively. It is concluded that divalent cations and D600 compete for the same binding site according to a 1:1 reaction. This site is presumably located inside the transverse tubular system and controls inactivation of the contractile force.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01871279
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  • 4
    Electronic Resource
    Electronic Resource
    New Prophosphatranes: Novel intermediates to five-coordinate phosphatranesDedicated to Professor Kurt Issleib on his 70th Birthday (1989)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 578 (1989), S. 75-80 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Neue Prophosphatrane: Neuartige Zwischenstufen auf dem Wege zu pentakoordinierten PhosphatranenDie Reaktion von N(CH2CH2NHMe)3 mit P(NMe2)3 oder P(NMe2)2Cl ergibt die Phosphatranvorstufe N(CH2CH2NMe)3P. Dessen Umsetzung mit Oxydationsmitteln ode Elektrophilen führt zu nicht-transannular-stabilisierten, tetrakoordinierten Derivaten N(CH2CH2NMe)3P—X, (X: O, S, Se, N3Ph, NPh, CS2, 1/2 PtCl2). Die Strukturen der beschriebenen Verbindungen werden anhand ihrer 1H-, 13C- und 31P-NMR-Daten diskutiert.
    Notes: The reaction of N(CH2CH2NHMe)3 with P(NMe2)3 or P(NMe2)2Cl yields the phosphatrane precursor N(CH2CH2NMe)2P,4. With oxydizing agents or electrophiles 4 is converted to the untransannulated four-coordinated derivatives N(CH2CH2NMe)3P—X, (X: O, S, Se, N3Ph, NPh, I CS2, 1/2 PtCl2). The structures of the compounds described are discussed by 1H, 13C, and 31P n.m.r. data.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19895780109
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  • 5
    Electronic Resource
    Electronic Resource
    C-metallierte Aminophosphine 1. α-lithiierte DimethylaminophosphineProfessor Marianne Baudler zum 65. Geburtstage am 27. April 1986 gewidmet (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 535 (1986), S. 47-55 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: C-metalated Aminophosphines. 1. α-lithiated DimethylaminophosphinesThe preparation of dimethylaminophosphines of the general formula Z—CH2—Pdma2 and (Z—CH2)2Pdma, respectively (Z = (CH3)3Si, C6H5), their monometalation and the reactions of these metalated species with chlorosilanes, bis-(dimethylamino)-chlorophosphine and trimethylsilylmethyl-dichlorophosphine are described. The n.m.r. spectra of the prepared compounds are discussed.
    Notes: Es wird die Darstellung von Dimethylaminophosphinen der allgemeinen Formulierung Z—CH2—Pdma2 bzw. (Z—CH2)2Pdma, deren Monolithiierung zu Z—CH(Li)—Pdma2 bzw. Z—CH(Li)—P(dma)—CH2—Z (Z = (CH3)3Si, C6H5) und die Reaktionen dieser lithiierten Spezies mit Chlorsilanen sowie Bis-(dimethylamino)-chlorphosphin und Trimethylsilylmethyldichlorphosphin beschrieben. Die NMR-Daten der dargestellten Verbindungen werden diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865350407
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  • 6
    Electronic Resource
    Electronic Resource
    Über die Cycloaddition von Dithiocyan und Trithiocyan mit Hexafluoraceton und Folgeprodukte aus der Spaltung der Schwefel-Schwefel-Bindung mit elementarem Chlor im Dithiocyan-Hexafluoraceton-AdduktProfessor Gerhard Gattow zum 60. Geburtstage am 6. Februar 1986 gewidmet (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 532 (1986), S. 131-136 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Cycloaddition of Dithiocyanogen and Trithiocyanogen with Hexafluoroacetone and Products of the Cleavage of the Sulfur-Sulfur Bond in Dithiocyan-Hexafluoroacetone Adduct by Elemental ChlorineThe reaction of dithiocyanogen and trithiocyanogen with hexafluoroacetone (HFA) leads to the cycloaddition products (SCN)2 · 4 HFA 1 and S(SCN)2 · 4 HFA 2. These are the first reactions of (SCN)2 and S(SCN)2 without cleavage of the S - S bonds. Elemental chlorine cleaves in 1 the S—S bond and 3 is formed. In 3 the chlorine atom can be replaced by the rests  - CN 4, (C6H11)2N -  5, and n-C4H9- 6. 6 eliminates one molecule of HFA by warming up and the four-membered ring 7 is formed. The compounds were characterized on the basis of mass and nmr spectra.
    Notes: Die Reaktion von Dithiocyan und Trithiocyan mit Hexafluoraceton (HFA) führt zu den Cycloadditionsprodukten (SCN)2 · 4 HFA 1 und S(SCN)2 · 4 HFA 2. Es sind die ersten Reaktionen des (SCN)2 und S(SCN)2, die nicht unter Spaltung der S—S-Bindungen verlaufen. Durch elementares Chlor wird 1 an der S—S-Bindung gespalten und es entsteht 3. In 3 kann das Chloratom durch die Reste  - CN 4, (C6H11)2N -  5 und n-C4H9- 6 ersetzt werden. Beim Erwärmen verliert 6 ein Molekül HFA und es entsteht der viergliedrige Ring 7. Die Verbindungen wurden anhand ihrer Massen- und NMR-Spektren eindeutig charakterisiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865320118
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  • 7
    Electronic Resource
    Electronic Resource
    Reaktion des aktivierten 1,2-Diphosphinobenzens mit Diphenylcarbodiimid (1985)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 529 (1985), S. 216-221 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Reaction of Activated 1,2-Diphosphinobenzene with Diphenylcarbodiimide.The reaction behaviour of 1,2-(Ptms2)2C6H4 and 1,2-(PHLi)2C6H4 towards Ph—N=C=N—Ph leads to phosphaguanidino derivatives of 1,2-diphosphinobenzene and 2-(phenyltrimethylsilylamino)-3-trimethylsilyl-1,3-benzodiphosphole. The structure of the compounds are discussed on the basis of their n.m.r. spectra.
    Notes: Die Umsetzungen von Tetrakis(trimethylsilyl)-1,2-diphosphinobenzen sowie von 1,2-Di(lithiophosphino)benzen mit Diphenylcarbodiimid führen zu Phosphaguanidino-derivaten des 1,2-Diphosphinobenzens sowie zum 2-(Phenyl-trimethylsilylamino)-3-trimethylsilyl-1,3-Benzodiphosphol. Die Strukturen der dargestellten Verbindungen werden anhand der NMR-Daten diskutiert.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19855291027
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  • 8
    Electronic Resource
    Electronic Resource
    Ueber Diphenylbasen (1878)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 11 (1878), S. 1754-1755 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.187801102141
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  • 9
    Electronic Resource
    Electronic Resource
    Ueber Diphenylbenzole (1878)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 11 (1878), S. 1755-1756 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.187801102142
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  • 10
    Electronic Resource
    Electronic Resource
    Ueber Azo-, Azoxy- und Hydrazoverbindungen (1879)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 12 (1879), S. 482-486 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.187901201137
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