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  • 11
    Electronic Resource
    Electronic Resource
    Low magnetic flux noise observed in laser-deposited in situ films of YB 2 Cu 3 O y and implications for high- T c SQUIDs (1989)
    [s.l.] : Nature Publishing Group
    Nature 341 (1989), S. 723-725 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The YBCO film was deposited on a (100) LaAlO3 substrate using 30-ns pulses of 248-nm ultraviolet radiation from a KrF excimer laser6'7 with an energy density of about 2 J cm~2 incident on a rotating stoichiometric target. The substrate was maintained at 650-750 °C to ensure in situ ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/341723a0
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  • 12
    Electronic Resource
    Electronic Resource
    Antigen specific, suppressor cells induced by the immunomodulator FCE 20696 in aged NZB/WF1 mice (1986)
    Springer
    Inflammation research 19 (1986), S. 315-317 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract FCE 20696 is a new synthetic immunomodulating agent, active on some manifestations of the autoimmune disease of NZB/WF1 mice, in which a disorder of T suppressor cells (SC) has been described to be of pathogenetic relevance. The ability of FCE 20969 to induce SC in NZB/WF1 mice, which are then able to specifically inhibit the production of anti autologous red blood cells antibodies (aRBC Ab), was investigated. NZB/WF1 mice were chronically treated with the compound starting from the ninth week of age, sacrificed at different times and their spleen cells transferred to 9 weeks old, syngeneic mice. In donor animals SC were induced by rat RBC, whereas in the recipients the suppressive activity of transferred cells was evaluated from the appearance of aRBC Ab induced by the same antigen. The results show that antigen specific SC were present in both FCE 20696 treated and control young animals. In older controls, SC couldn't be induced, whereas in treated animals SC were present and able to transfer suppression into the recipents. FCE 20696 was active at 1.5 mg/Kg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971236
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  • 13
    Electronic Resource
    Electronic Resource
    Italian experience regarding the prevention of Duchenne and Becker muscular dystrophies (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 412-415 
    Details
    ISSN: 1432-1076
    Keywords: Duchenne muscular dystrophy, Becker muscular dystrophy ; Carrier diagnosis ; Prenatal diagnosis ; X-linked muscular dystrophies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The indirect approach to carrier detection and prenatal diagnosis of Duchenne and Becker muscular dystrophies based on the study of DNA polymorphisms closely linked to this gene has been followed by five Italian laboratories in the study of 106 pedigrees. Out of 354 women studied up to 1 May 1987, 147 were identified as carriers because of pedigree information and/or of increased creatine phosphokinase (CPK) values. Of the remaining 207, 184 could be assigned to three arbitrarily defined risk categories (low, intermediate and high) using linkage analysis. This disaggregation of women at risk is clearly more useful than that defined before DNA analysis, in which the same 184 women could be assigned only to the low or intermediate risk categories. Prenatal diagnosis was theoretically possible in 90% of carrier women, and was actually performed in 14 pregnancies, which led to the identification of four affected male foetuses, one also having Down syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496422
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  • 14
    Electronic Resource
    Electronic Resource
    Plasma levels and myocardial content of verapamil, norverapamil and two N-dealkyl-metabolites in man (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 653-657 
    Details
    ISSN: 1432-1041
    Keywords: verapamil ; plasma levels ; myocardial uptake ; verapamil metabolites ; patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma levels and myocardial content of verapamil and its metabolites norverapamil, N-dealkylverapamil and N-dealkylnorverapamil were determined in 15 patients with valvular [3] or ischaemic [12] heart disease. The mean myocardial plasma concentration ratio (M/P) was 7.05 for verapamil, 11.45 for norverapamil, 8.93 for N-dealkylverapamil, and 11.33 for N-dealkylnorverapamil, with great interpatient variability. The highest M/P ratios of verapamil were generally found in patients with the lowest plasma levels, suggesting that saturable tissue uptake may occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607910
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  • 15
    Electronic Resource
    Electronic Resource
    Isolation and characterization of cytopathic strains of rotavirus from rabbits (1985)
    Springer
    Archives of virology 83 (1985), S. 99-104 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three cytopathic rotavirus isolates were recovered from young rabbits affected by an enteric syndrome. The three isolates, when compared by cross serum-neutralization tests, were found to be of the same serotype. Cross neutralization occurred also between a representative of the rabbit isolates and one strain of bovine rotavirus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310967
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  • 16
    Electronic Resource
    Electronic Resource
    Peripheral neuropathy in Cockayne syndrome (1986)
    Springer
    Neurological sciences 7 (1986), S. 447-452 
    Details
    ISSN: 1590-3478
    Keywords: Cockayne's syndrome ; peripheral neuropathy ; sural nerve biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Vengono descritti due casi di Sindrome di Cockayne. In un caso è stata effettuata una biopsia del nervo surale che ha evidenziato una neuropatia periferica di tipo demielinizzante con rare inclusioni nelle cellule di Schwann, formate da materiale osmiofilo finemente granulare, vacuoli e strutture lamellari. Il significato di tali inclusioni è molto incerto. La presenza inoltre di corpi osmiofili lamellari intrassonali suggerisce una associata compromissione assonale.
    Notes: Abstract Two siblings with Cockayne syndrome are reported. In one case a sural nerve biopsy showed a demyelinating peripheral neuropathy with occasional inclusions in Schwann cells made up of electron dense finely granular material intermingled with vacuoles or lamellar structures. The significance, if any, of this accumulated material remains unclear. The presence, in addition, of small finely lamellar intra-axonal osmiophilic bodies suggests an associated axonal involvement
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02283024
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  • 17
    Electronic Resource
    Electronic Resource
    Noninvasive determination of the anaerobic threshold in canoeing, cross-country skiing, cycling, roller, and iceskating, rowing, and walking (1985)
    Springer
    European journal of applied physiology 53 (1985), S. 299-303 
    Details
    ISSN: 1439-6327
    Keywords: Anaerobic threshold ; Aerobic power ; Factors limiting aerobic events ; Work intensity-heart rate relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between velocity (V) and heart rate (HR) was determined in four canoeists, 42 cross-country skiers, 73 cyclists, nine ice-skaters, 10 roller-skaters, 32 rowers, and 20 walkers. The athletes were asked to increase their work intensity progressively, from low to submaximal velocities; HRs were determined by ECG in roller-, ice-skating, and walking, or read on a cardiofrequency meter in canoeing, cross-country skiing, cycling, and rowing. In all the athletes examined the linearity of the V-HR relationship was maintained up to a submaximal speed (deflection velocity, Vd), beyond which the increase in work intensity exceeded the increase in HR. Vd and anaerobic threshold (AT), determined through blood lactate measurements, were coincident in 19 athletes (6 cross-country skiers, 3 cyclists, 2 roller-skaters, 3 rowers, and 5 walkers). Vd was correlated with the average speeds maintained in walking (20km, n=13, r=0.88), cross-country skiing (15 km, n=20, r=0.80; 30 km, n=8, r=0.82; 12 km, n=7, r=0.86; 11 km, n=7, r=0.86) and cycling (1,000 m flying-start, n=68, r=0.83), thus showing that AT is a limiting factor in these aerobic events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422842
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  • 18
    Electronic Resource
    Electronic Resource
    Field trial evaluation of an inactivated rotavirus vaccine against neonatal diarrhea of calves (1987)
    Springer
    European journal of epidemiology 3 (1987), S. 5-9 
    Details
    ISSN: 1573-7284
    Keywords: Rotavirus vaccine ; Neonatal calf diarrhea ; Field trials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Field trials were conducted using an inactivated rotavirus vaccine for prevention of calf neonatal diarrhea. For the trials, 458 pregnant cows from 26 herds were involved. In each herd, cows which had been inseminated within a period of two months were selected and randomly subdivided in two groups. Cows in one group (248 head in total) were vaccinated 6 weeks before calving and again 4 weeks later; cows in the other group (210 head in total) were left as unvaccinated controls. At calving, colostrum was collected from each cow and stored at -30°C until used for feeding calves. The newborn calves, beginning the second day of life and for the next 7–10 consecutive days, each was fed a daily supplement of 400 ml of colostrum from its dam. The diarrhea occurred in 86 (40.9%) calves that had received colostrum from unvaccinated dams (normal colostrum), and in 7 (2.8%) calves which were fed colostrum from vaccinated dams (immune colostrum). The disease was very severe in the normal colostrum-fed calves and 52 of them died. Those calves which survived the disease underwent a significant loss of condition. By contrast, the 7 immune colostrum-fed calves displayed a rather mild enteric condition, and all recovered without any sequela being observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00145064
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  • 19
    Electronic Resource
    Electronic Resource
    A comparison of rotavirijs strains of bovine, simian and porcine origin (1985)
    Springer
    European journal of epidemiology 1 (1985), S. 274-280 
    Details
    ISSN: 1573-7284
    Keywords: Rotavirus ; Bovine ; Simian ; Porcine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three rotavirus strains of bovine, simian and porcine origin, respectively, were compared. The 3 viruses induced a classic rotavirul infection in newborn, conventionally reared calves. The cross neutralization tests revealed an antigenic identity of simian and porcine rotaviruses and a slight serologic correlation of these two viruses with the bovine rotavirus strain. However, in reciprocal cross protection tests carried out in calves, the simian rotavirus antiserum afforded weak protection to challenge infection with either the porcine or the bovine viruses. By contrast, the protective level of the bovine and the porcine rotavirus antisera was relatively high. It was speculated that the 81/36F bovine rotavirus could be considered, tentatively, as an antigenic reassortant rotavirus strain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237102
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  • 20
    Electronic Resource
    Electronic Resource
    Immunization against bovine rotaviral infection (1989)
    Springer
    European journal of epidemiology 5 (1989), S. 279-284 
    Details
    ISSN: 1573-7284
    Keywords: Rotavirus ; Immunization ; Calves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calves fed with colostrum from cows vaccinated with an inactivated rotavirus vaccine were refractory to experimental infection with strain 81/36F of bovine rotavirus. In the field study, 458 pregnant cows from 26 herds were involved. In each herd, cows were selected and randomly subdivided in two groups. Cows in one group (248 head in total) were vaccinated, whereas cows in the other group (210 head in total) were left as unvaccinated controls. At calving, colostrum was collected from each cow and stored at -30°C until used for feeding calves. The newborn calves, beginning the second day of life and for the next 740 days, were each fed a daily supplement of 400 ml of colostrum from its dam. The diarrhea occurred in 86 (40.9%) calves that had received colostrum from unvaccinated dams (normal colostrum), and in 7 (2.8%) calves which were fed colostrum from vaccinated dams (immune colostrum). The disease was very severe in the normal colostrum-fed calves and 52 of them died. By contrast, the 7 immune colostrum-fed calves displayed a rather mild enteric condition, and all recovered without any sequela being observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00144827
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