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  • 1
    Electronic Resource
    Electronic Resource
    Low temperature properties of (La, Nd)Sn3 alloys (1979)
    Springer
    The European physical journal 34 (1979), S. 65-77 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Dilute (La1−x Nd x )Sn3 alloys with 0.01〈x〈0.15 are characterized by determination of the superconducting transition temperatureT c as well as low temperature measurements of the specific heat and inelastic neutron scattering. As an important result of these experiments we found that the Nd impurities in LaSn3 exist as stable trivalent ions, in contrast to all other light rare earths. In addition, specific heat and neutron scattering results revealed the scheme of crystal field (CF) levels of Nd3+. Using this level scheme, the concentration dependence of the superconducting transition temperature,T c (x), could be quantitatively fitted up tox≃9 at % by the theory of Keller and Fulde [J. Low. Temp. Phys.4, 289 (1971)]. From the relatively high initial slope ofT c (x) we inferred that — besides isotropic spin exchange — other pair-breaking processes are important. In contrast toT c (x), the reduced specific heat jumpsΔC/ΔC 0 as a function ofT c /T c0 (whereT c0 andΔC 0 refer to LaSn3) were found to lie considerably below the theoretical curve for isolated Nd3+ ions. This is explained by Nd—Nd interactions resulting in a mean Zeeman splitting (〈k B T c ) of the CF ground state, which could be directly observed in the form of broadened Schottky humps in the normal state specific heats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01362780
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  • 2
    Electronic Resource
    Electronic Resource
    Triploidie als Ursache von Schwangerschaftsgestose im 2. Trimenon (1975)
    Springer
    Archives of gynecology and obstetrics 218 (1975), S. 113-123 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Fall von kindlicher Triploidie wird vorgestellt. Die Schwangerschaft war gekennzeichnet durch therapieresistente EPH-Gestose im 2. Trimenon mit Übergang in Präeklampsie in der 33. Woche. Der durch Sectio entbundene, nicht lebensfähige Fetus war äußerlich weiblich, untergewichtig, hypoton und asphyktisch. Er wies eine Hirnmißbildung mit Kebozephalie, einem großen univentrikulären Hohlraum und Fehlen der Hypophyse sowie multiple Mißbildungen und dysmorphe Zeichen auf. Bei der Sektion fanden sich Hypo- und Dysplasie der Nebennieren; Uterus, Tuben und Ovarien waren nicht angelegt, Testes waren nicht nachweisbar. Die Plazenta war auffallend groß und zeigte herdförmige hydatidiforme Degenerationen der Zotten. Der Karyotyp war 69,XXY, und mit Hilfe der Fluoreszenzmarker ließ sich der väterliche Ursprung des überzähligen haploiden Satzes nachweisen. Die für Triploidie typischen Schwangerschaftsbefunde werden besprochen und auf die Möglichkeit der pränatalen Diagnose durch Chromosomenuntersuchung an gezüchteten Zellen der Amnionflüssigkeit wird hingewiesen.
    Notes: Summary The authors report a case of triploidy in a prematurely born child. The pregnancy was complicated by severe toxemia beginning during the second trimester and terminating in preeclampsia leading to cesarian section in the 33th week of gestation. The externally female child was underweight, hypotonic and asphyctic and died shortly after birth. She exhibited a complex brain malformation including excessive hydrocephaly, cebocephaly and aplasia of the piturary gland, and multiple dysmorphic signs. Autopsy revealed hypoplasia and dysplasia of the adrenal glands; no uterus, tubes and ovaries were present, but no testes were found. The placenta showed localized hydatidiform degeneration and was relatively large. The karyotype was 69,XXY, and with the aid of fluorescence markers, paternal origin of the additional haploid chromosome set was demonstrated. Typical findings in pregnancies with fetal triploidy are discussed and the possibility of prenatal diagnosis of triploidy by chromosome analysis in cultivated amniotic fluid cells is pointed out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01395911
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  • 3
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    Unknown
    Socratic Moderation and Self-Knowledge (1983)
    Berkeley, Calif. : Periodicals Archive Online (PAO)
    Journal of the history of philosophy. 21:3 (1983:July) 339 
    Details
    ISSN: 0022-5053
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:b151-1983-021-03-000004
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  • 4
    Electronic Resource
    Electronic Resource
    IR absorption of highly vibrationally excited SF6 (1978)
    Springer
    Applied physics 15 (1978), S. 297-301 
    Details
    ISSN: 1432-0630
    Keywords: 33
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract In a double-resonance experiment, the absorption of various CO2 laser lines by sulfur hexafluoride was measured, before and after the SF6 was pumped by a fixed frequency CO2 laser to a level of 5 quanta/molecule. The absorption is substantially shifted to longer wavelengths. But the short wavelength wing of the absorption band is not completely bleached. Instead a shoulder of several cm−1 width is left. This shoulder is probably important for the explanation of the infrared laser induced dissociation of SF6.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00896111
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  • 5
    Electronic Resource
    Electronic Resource
    Glucocorticoid receptors and sensitivity in leukemias (1981)
    Springer
    Annals of hematology 42 (1981), S. 183-190 
    Details
    ISSN: 1432-0584
    Keywords: Glucocorticoid-Rezeptoren ; Sensitivität ; Leukämie ; Glucocorticoid receptors ; Sensitivity ; Leukemias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In an attempt to investigate the utility of glucocorticoid receptor determination to predict clinical responsiveness in human leukemias we have studied glucocorticoid receptors in the leukemic cells from 46 patients and in the lymphocytes from 18 normal donors. In the normal lymphocytes there were 3,875 (Median) specific binding sites per cell. The blasts from 17 patients with ANLL had on average higher levels of binding sites per cell (Median = 7,250, range: 0 to 15,295) than the other leukemias. Of the 15 patients with CLL, six had received glucocorticoid treatment for 3 to 5 years. Their lymphocytes had lower number of receptors (Median = 2,000) than the other cases which were newly diagnosed (Median = 4,500). Four patients had ALL/AUL, three patients had blast crisis as terminal phase of CML, and seven had leukemic Non-Hodgkin lymphomas (Median = 3,500 sites/cell). In 24 patients we have also studied the in vitro sensitivity of the leukemic cells to dexamethasone. There was no marked correlation between glucocorticoid receptor levels and in vitro sensitivity. An attempt to correlate receptor levels with clinical responsiveness demonstrated that glucocorticoid receptor determination might be of value in patients with lymphoid malignancies but probably not in patients with other leukemias.
    Notes: Zusammenfassung Zur Prüfung der Frage, ob eine positive Korrelation zwischen dem Steroid-Rezeptorgehalt von Leukämiezellen und dem Erfolg einer Steroid-Therapie besteht, haben wir Glucocorticoid-Rezeptoren bei Leukämien und Lymphomen untersucht. Die Bestimmung erfolgte nach Baxter und Tomkins. Untersucht wurden 46 Patienten mit Leukämien und 18 Kontrollpersonen. Normale Lymphozyten haben durchschnittlich 3875 spezifische Bindungsstellen pro Zelle. Die Anzahl der Glucocorticoid-Rezeptoren in den Blasten von 17 Patienten mit akuter myeloischer Leukämie zeigten starke Schwankungen (Bereich 0 bis 15295 Rezeptoren pro Zelle). Sechs von 15 Patienten mit chronischer lymphatischer Leukämie wurden seit Jahren mit Glucocorticoiden behandelt und sprachen zur Zeit der Steroid-Rezeptor-Bestimmung auf diese Therapie nicht mehr an. Die Anzahl der Steroid-Bindungsstellen der Lymphozyten dieser Patienten erwies sich im Mittel als niedriger (2000 je Zelle) als bei den unbehandelten Patienten (4500 je Zelle). Bei 24 Patienten haben wir auch die In-Vitro-Sensitivität der Leukämiezellen gegenüber Dexamethason untersucht. Es konnte keine eindeutige Korrelation zwischen Rezeptorengehalt und In-Vitro-Sensitivität festgestellt werden. Weitere Analysen mit klinischen Daten weisen darauf hin, da\ die Bestimmung von Glucocorticoid-Rezeptoren für die Planung und Durchführung einer Therapie bei den lymphatischen Leukämien Bedeutung erlangen kann, jedoch wahrscheinlich nicht bei den myeloischen Leukämien.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01026388
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  • 6
    Electronic Resource
    Electronic Resource
    Plan for the swiss randomized hail suppression experiment. Design of Grossversuch IV (1978)
    Springer
    Pure and applied geophysics 117 (1978), S. 548-571 
    Details
    ISSN: 1420-9136
    Keywords: Hail prevention ; Randomized seeding ; Statistical design
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract An experimental research program is described which investigates the possibility of reducing hailfall in an area of 1000 km2 using the Moldavian rocket seeding method. It involves a design in which experiments are randomized (50∶50) by day over a fixed experimental area. The evaluation is based on data collected during the experimental unit (12–2100 hours). The test variable is hail kinetic energy measured by hailpads and by a hailpad-adjusted S-band radar. A description of the experimental area, the instrumentation and the seeding method adapted from the Soviet Union as well as calculations of the nuclei plume behaviour after seeding with large Oblako rockets are presented. The statistical design is given as well as an extensivea priori description of the confirmatory evaluation procedure which will be used to prove an eventual seeding effect. It is recognized that good predictors are essential to arrive at a statistically significant results in 5 years. From synoptic and radar data obtained during the preliminary phase of the experiment a predictor function is derived. A concomitant variable (cloud base temperature) is proposed taking into account a possibly variable reaction of different storm types to the seeding. The development of the statistical test to be used is also described. Section 7 indicates some possibilities for further exploratory analyses with emphasis on hailpad measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00876634
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  • 7
    Electronic Resource
    Electronic Resource
    Trisomy 6q25→6qter in a severely retarded 7-year-old boy with turricephaly, bow-shaped mouth, hypogenitalism and club feet (1979)
    Springer
    Human genetics 〈Berlin〉 46 (1979), S. 279-284 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Trisomy for a small terminal segment of chromosome 6q produces a characteristic syndrome of malformations and dysmorphic signs which, on the basis of comparison with a previously published case, may be suspected on clinical grounds. The present case concerns a 7-year-old boy, the son of a carrier mother t(6;14)(q25;qter). The main symptoms are: very severe physical and mental retardation, turricephaly, Cupid's bow mouth with narrow lips, almond-shaped eyes with narrow palpebral fissures and ptosis, micropenis with absence of scrotum, club feet, hammer toes, and extension contractures. In addition, there are a great many minor dysmorphic features.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273311
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  • 8
    Electronic Resource
    Electronic Resource
    Trisomy for the distal third of the long arm of chromosome 19 in brother and sister (1979)
    Springer
    Human genetics 〈Berlin〉 46 (1979), S. 263-270 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Trisomy for the distal third of the long arm of chromosome 19 was observed in a 12-year-old boy and his 9-year-old sister. Both are affected by extremely severe statural and psychomotor retardation. The physical symptoms common to both are dwarfism, micro- and brachycephaly, antimongoloid slant of the eyes, hypertelorism, ptosis, short nose, short philtrum, poorly formed ears, short neck with excess skin, barrel-shaped thorax, diastasis of rectus muscles, kyphosis, sacral dimple, excess of digital arches, pedes valgi, laterally curved big toes, epilepsy and muscular hypotonia. The chromosomal anomaly was transmitted by the mother, who is the carrier of a translocation t(19;20)(19q133;20pter). In the pedigree, extending over four generations, among 30 pregnancies fathered or mothered by 5 carriers resulted in: 6 individuals with normal karyotype, 9 carriers, 2 confirmed and 2 presumptive unbalanced abnormal children, and 10 abortions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273309
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  • 9
    Electronic Resource
    Electronic Resource
    The delivery of genetic counseling services in Europe (1980)
    Springer
    Human genetics 〈Berlin〉 56 (1980), S. 1-5 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Oranizational forms and the current status of genetic counseling within the health care system of 15 European countries were evaluated by questionnaire and at a symposium, with individuals present from Austria, Belgium, Czechoslovakia, Denmark, the Federal Republic of Germany, the German Democratic Republic, Finland, France, Hungary, Italy, the Netherlands, Norway, Switzerland, the United Kingdom, and the Soviet Union. In spite of wide differences between these countries, certain similarities with respect to the delivery of genetic counseling services could be observed: (i) most genetic counseling is done within university institutions or closely linked to it; (ii) governmental support of genetic counseling is developing slowly, and genetic counseling is usually not yet fully integrated into the health care system; (iii) there is lack of qualified personnel; (iv) no guide lines for formal education have been developed, but a postgraduate training period of no less than four years is considered a minimum; (v) without appropriate support, genetic counseling is a burden for research in human genetics; yet, a strict separation of genetic counseling and research activities is not recommended; (vi) on the average, a team providing genetic counseling for about 1–2 million people should consist of 3–4 physicians, 5–10 technicians, 2–3 secretaries, and other supportive personnel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00281565
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  • 10
    Electronic Resource
    Electronic Resource
    The “Cat Eye syndrome”: Dicentric small marker chromosome probably derived from a No. 22 (Tetrasomy 22pter→q11) associated with a characteristic phenotype (1981)
    Springer
    Human genetics 〈Berlin〉 57 (1981), S. 148-158 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Eleven patients with the so-called Cat Eye syndrome are reported including a more detailed description of the original cases reported by Schnid and Fraccaro. All cases had, in addition to a normal karyotype, a small extra G-like chromosome which appeared to be an isochromosome for the juxtacentromeric region (pter→q11) of an acrocentric chromosome. None were mosaics. Clinical findings and further cytogenetic studies in a few cases suggest that these markers probably derive from a No. 22 chromosome. Characteristic features of the Cat Eye syndrome in these 11 patients and those reviewed from the literature are: ocular coloboma which may involve the iris, choroid and/or optic nerve, preauricular skin tags and/or pits which are probably the most consistent feature, congenital heart defect, anal atresia with a fistula, renal malformations such as unilateral absence, unilateral or bilateral hypoplasia, and cystic dysplasia, and antimongoloid position of eyes. Intelligence is usually low-normal, although moderate retardation is also seen. There is great variability in the clinical findings ranging from near normal to lethal malformations. Less frequent, but also characteristic findings are: microphthalmia, microtia with atresia of the external auditory canal, intrahepatic or extrahepatic biliary atresia and malrotation of the gut. Direct transmission of the marker from one generation to the other was observed in both sexes. In those families, there was considerable variability in the clinical findings between affected family members. Theses cases show that there is a bias of ascertainment for patients who have the more striking malformation, especially those with ocular coloboma and anal atresia, a combination which appears to be present in only a minority of cases. Many mildly affected patients probably remain undetected. It is proposed that the term Cat Eye syndrome should be applied only to cases with trisomy or tetrasomy of not more than 22pter→q11 and without additional duplication or deletion of another autosomal segment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282012
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