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  • 1980-1984  (9)
  • 1970-1974  (2)
  • 1960-1964  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Refined structure of phenazine–iodine molecular complex, C12H8N2.I2 (1984)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 40 (1984), S. 139-140 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270184003322
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  • 2
    Electronic Resource
    Electronic Resource
    Fractionation of Two Metabolically Distinct Classes of Ribonucleic Acids in Animal Cells and its Bearings on Cancer (1960)
    [s.l.] : Nature Publishing Group
    Nature 186 (1960), S. 215-217 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RECENTLY we have shown1 that the treatment of suspensions or homogenates of normal and malignant animal cells with aqueous phenol may lead to a fractionation of their ribonucleic acids into two components differing markedly in the nucleotide composition and the rate of uptake of phosphorus-32. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/186215a0
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  • 3
    Electronic Resource
    Electronic Resource
    Changes in Natural Killer Activities in Experimental Secondary Amyloidosis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 19 (1984), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Natural killer (NK) cell aciiviiy in experimental murine amyloidosis was studied. In CBA/J mice, which show a high incidence of amyloidosis. NK activity was significantly decreased after 1 week of casein treatment. In C3H mice, which show a low incidence of amyloidosis, NK activity was not changed by casein treatment. Pretreatment with lipopolysaccharide in vivo enhanced the NK activities in CBA/J and C3H mice. These increases were not observed after casein treatment. The lowered NK activity of cells from CBA/J mice after casein treatment was restored to the normal range by indomethacine in vitro. Depletion of adherent cells from the spleen cells treated with casein had no effect on NK activity. Single-cell assay showed that casein treatment impaired the killing but not the binding of NK cells to target cells. After casein treatment, the splenic serum amyloid A (SAA) level gradually increased in CBA/J mice but remained low in C3H mice. NK activity was suppressed by the addition of serum obtained from CBA/J mice treated with casein but not by normal control serum. And partially purified AA protein obtained from the spleen of CBA/J mice treated with casein also suppressed NK activity in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1984.tb00962.x
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  • 4
    Electronic Resource
    Electronic Resource
    Enzymatic Synthesis of Optically Pure 1-Carbacephem Compounds (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 434 (1984), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1984.tb29828.x
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  • 5
    Electronic Resource
    Electronic Resource
    Elektrische Untersuchungen am Nervus ampullaris lateralis bei Kaninchen (1960)
    Springer
    European archives of oto-rhino-laryngology and head & neck 177 (1960), S. 31-38 
    Details
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Autoren legten N. amp. lat. des Kaninchens frei, führten dort die Mikro-elektrode ein und registrierten die Potentialänderung nach der calorischen Reizng des Labyrinthes. Abgesehen von der bereits bekannten Zu- und Abnahme der Grundaktivität konnten die negativen Potentialänderungen registrieert werden. Im Photogramm wurde die Elektronystagmographie mit der Potentialänderung gleichzeitig registriert, und in jedem Falle, wenn das Potential auftrat, wurde Nystagmus beobachtet. Die Genese dieser Potentialänderungen konnte noch nicht festgestellt werden, aber es ist anzunehmen, daß sich die Potentiale als eien Erscheinung im peripheren Labyrinth finden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02105821
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  • 6
    Electronic Resource
    Electronic Resource
    Simultaneous determination of sodium and potassium in human urine or serum using coated-wire ion-selective electrodes based on bis(crown ether)s (1983)
    Springer
    Microchimica acta 80 (1983), S. 287-296 
    Details
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Hochleistungsfähige ionen-selektive Elektroden auf der Basis von Dodecylmethyl-bis-(12-kronen-4)- und Bis-(benzo-15-kronen-5)-ether wurden für die simultane Bestimmung von Natrium und Kalium in menschlichem Harn bzw. Serum mit Hilfe von Gran's plot method verwendet. Die Ergebnisse der potentiometrischen Bestimmung stehen mit denen der Flammenphotometrie in guter Übereinstimmung.
    Notes: Summary High-performance coated-wire ion-selective electrodes based on dodecylmethyl bis(12-crown-4) and bis(benzo-15-crown-5) are used for the simultaneous determination of Na+ and K+ in human urine or serum by means of the Gran's plot method. The results of the potentiometric determination for Na+ and K+ in human urine or serum are in good agreement with the values obtained by flame photometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01213123
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  • 7
    Electronic Resource
    Electronic Resource
    Enzyme-and immuno-histochemical localization of kallikrein (1984)
    Springer
    Histochemistry and cell biology 80 (1984), S. 367-372 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Localization of kallikrein in the human parotid gland was investigated simultaneously by two markers: kallikrein-like (enzyme) activity and kallikrein antigenicity. Kallikrein-like activity was histochemically demonstrated by using a synthetic substrate, pro-phe-arg-naphthylester. Kallikrein antigenicity was demonstrated by an unlabelled antibody peroxidase-antiperoxidase method, where monospecific antiserum against highly purified urinary kallikrein was used as the primary antiserum. The results showed that kallikrein-like activity and kallikrein antigenicity were identical in their locations in the ductal cells, being localized in the luminal part of the striated ducts and to a lesser degree in the excretory ducts. This indicates the presence of active kallikrein in these regions. No enzyme activity nor antigenicity was observed either in acini or in intercalated ducts. Moreover, the peroxidase-antiperoxidase method reveated kallikrein antigenicity for the first time extracellularly in the basement-membrane region of acini and of ducts as well as in the interstitium surrounding ducts and major vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495419
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  • 8
    Electronic Resource
    Electronic Resource
    Histochemical localization of kallikrein-like pro-phe-arg-naphthylester esterase activity in the rat kidney (1982)
    Springer
    Histochemistry and cell biology 75 (1982), S. 91-98 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the rat kidney the presence of the kallikrein-like pro-phe-arg-naphthylester esterase activity was demonstrated by a simultaneous coupling azo dye method. The enzyme was identified as a serine-protease because it was inhibited by preincubation with diisopropyl-fluorophosphate and unaffected by sodium iodoacetate. Since kallikrein is a serine-protease and pro-phe-arg-naphthylester is a synthetic and sensitive substrate for kallikrein, the enzyme activity revealed by this method was considered to represent kallikrein, although non-kallikrein esterase activity is not totally excluded. The enzyme activity was localized mainly in the outer stripe of the outer medulla, with focal extensions primarily only in the lower half of the cortex corresponding to the medullary rays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492536
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  • 9
    Electronic Resource
    Electronic Resource
    Enzyme- and immuno-histochemical localization of kallikrein (1984)
    Springer
    Histochemistry and cell biology 80 (1984), S. 443-448 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Localization of kallikrein in the human kidney was investigated by two markers: kallikrein-like activity and kallikrein antigenicity. Kallikrein-like activity was demonstrated enzyme-histochemically by using a synthetic substrate for kallikrein, pro-phe-arg-naphthyl-ester. Kallikrein antigenicity was demonstrated by the unlabelled antibody peroxidase-antiperoxidase method using an antiserum against human urinary kallikrein. The kallikrein-like activity was localized in the proximal tubular cells without any corresponding kallikrein antigenicity. Neither kallikrein-like activity nor kallikrein antigenicity was noticed in any other tubular cell. These results are contrary to those in the ductal cells of the human parotid gland where the kallikrein-like activity and the kallikrein antigenicity were identical in their locations. The peroxidase-antiperoxidase method revealed, for the first time, kallikrein antigenicity both in the interstitium and in the basement membrane region of Bowman's capsule and of all the tubules, possibly representing circulating glandular kallikreins deposited in the renal tissue. Thus, the present findings are consistent with the hypothesis that the urinary (renal) kallikreins are derived from circulating glandular kallikreins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495432
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  • 10
    Electronic Resource
    Electronic Resource
    Analysis of natural killer activity and antibody-dependent cellular cytotoxicity in healthy volunteers and in patients with primary lung cancer and metastatic pulmonary tumors (1982)
    Springer
    Journal of cancer research and clinical oncology 102 (1982), S. 195-214 
    Details
    ISSN: 1432-1335
    Keywords: NK activity ; Antibody-dependent cellular cytotoxicity ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the contribution of ADCC and NK activities to host immune response against cancer, the characteristics of cells mediating these activities were examined in the peripheral blood lymphocytes of normal volunteers, and the changes of these activities were also evaluated in patients with lung cancer and metastatic pulmonary tumors before and after chemotherapy. OAT cells derived from small cell carcinoma of the lung and K-562 cells derived from erythroleukemia were used as target cells of ADCC and/or NK assay. ADCC and NK activities were not changed according to age, sex, and blood type. Mild and marked personal difference were observed in ADCC and NK activity, respectively. These activities were also influenced by environment. ADCC and NK activities of normal adult volunteers were diversely correlated at the coefficient of γ-0.426. NK activities were high against K-562 and CCRF-CEM cells, and low against BALL and OAT cells. NK activity against K-562 cells was strongly inhibited by K-562 or CCRF-CEM cells with high NK sensitivity, on the other hand, it was slightly inhibited by OAT and BALL cells with low NK sensitivity. NK activity against OAT cells was strongly inhibited by OAT, K-562 and CCRF-CEM cells, but not inhibited by BALL cells. The effector cells mediating NK activity were identified as non-adherent, E-receptor-positive, Fc-receptor-positive small lymphocytes. NK activity was not decreased before chemotherapy in patients with stage III primary lung cancer and metastatic pulmonary tumors. It was decreased only in patients of bad performance status, and it was significantly decreased in all patients after chemotherapy. ADCC also exhibited the tendency to decrease after chemotherapy in tumor-bearing patients. The recovery of NK-activity after chemotherapy well correlated with the effect of chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411340
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