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  • 1
    Electronic Resource
    Electronic Resource
    Adjuvant chemotherapy in osteosarcoma — Effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 1-7 
    Details
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Preoperative chemo-therapy ; Limb salvage ; High dose methotrexate ; Interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a cooperative adjuvant chemotherapy study of osteosarcoma (COSS-80), 192 patients were registered from December 1979 to March 1982. Fortyone patients have been excluded from study because of their nonadjuvant situation, therapy-limiting clinical conditions, or inadequate diagnosis. One hundred and fifty-one patients have been randomized to receive either the drug combination bleomycin+cyclophosphamide+dactinomycin (BCD) or cisplatinum (CPL) within a course of sequential multidrug chemotherapy including adriamycin (ADR) and high dose methotrexate (HDMTX). After exclusion of 51 patients with some deviation in history and/or management 100 selected patients were randomized once more to receive in addition or not fibroblast interferon after preoperative chemotherapy and surgical removal of the primary tumor. Patients were stratified for age and sex and for site and extension of tumor as well in both randomizations. Median follow up is now 12 (1–16) months. The expected 2-year disease free survival (DFS) rate of the total doubly randomized group is 78% and of the single randomized group 76%. No difference could be discerned between recombined groups receiving BCD vs CPL or interferon vs no interferon. The effect of preoperative chemotherapy on the tumor was evaluated clinically and by histopathologic grading; 66/85 (78%) patients were judged clinically as responders with pathohistologic verification of this finding in 71% of these cases. No adverse effect arose from delaying definite surgery for preoperative chemotherapy, but initial application of chemotherapy as well as planning, preparing, and performing of the surgical procedure have been facilitated. The majority of patients received some kind of limb-salvage treatment without local recurrences so far. A statistically insignificant but intriguing tendency for a slightly higher incidence of pulmonary metastases after resection as opposed to amputation could be detected. Similar to observations in the previous study COSS-77.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00625042
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  • 2
    Electronic Resource
    Electronic Resource
    Combined ultrastructural, histochemical, and autoradiographic study of osteosarcoma after preoperative chemotherapy according to the COSS 80 protocol (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 25-31 
    Details
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Chemotherapy ; Electronmicroscopy ; Histochemistry ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twelve osteosarcomas treated according to the COSS 80 protocol (preoperative chemotherapy, resection) were studied by light and electron microscopic, histochemical, and autoradiographic methods. Evidence of regressive and necrotic changes was found in many tumor cells, but the alterations were unspecific. Viable tumor cells of high malignancy were also observed regularly, often at the S phase. As the tumor regression continued, a strong reaction of the mononuclear phagocyte system was manifested by the presence of macrophages and giant cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00625048
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Serum-Sialyltransferase activity in cancer patients (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 445-449 
    Details
    ISSN: 1432-1440
    Keywords: Sialyltransferase ; Malignant diseases ; Sensitivity, specifity ; Tumor marker ; Diagnostic value ; Sialyltransferase ; Maligne Erkrankungen ; Sensitivität, Spezifität ; Tumormarker ; diagnostischer Wert
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Sialyltransferase-Aktivität wurde bei 116 Patienten mit Tumoren verschiedenen Ursprungs und unterschiedlicher klinischer Stadien im Serum bestimmt. Nur bei Patienten mit Metastasen fand sich eine signifikant erhöhte Serum-Sialyltransferase-Aktivität im Vergleich zum Normalkollektiv. Eine gesteigerte Enzymaktivität wurde aber auch bei Rheumatikern und Hepatitispatienten ermittelt, nicht dagegen bei an zystischer Fibrose erkrankten Kindern. Einige Serien von Tumorpatienten wurden zusätzlich auf andere Tumormarker hin untersucht (Carcinomembryonales Antigen, Alkalische Phosphatase: Regan-Isoenzym, Creatinkinase: BB-Isoenzym, Lactatdehydrogenase: Isoenzym 5), und die Ergebnisse mit den klinischen Diagnosen verglichen. Die Sensitivität und die Spezifität der Serum-Sialyltransferase als Tumormarker wird diskutiert.
    Notes: Summary Serum-sialyltransferase activity was measured in serum samples of 116 patients with malignant tumors of various origins and different clinical stages using asialo-fetuin as the acceptor and cytidine-5′-mono-phospho[14C]sialic acid as the donor. Only patients with metastatic tumors had significantly elevated serum-sialyltransferase levels. Increased enzyme activity was also associated with rheumatoid arthritis and with acute hepatitis, whereas no significant alteration of enzyme activity was observed in cystic fibrosis patients. In a group of tumor patients, various additional tumor markers were determined (carcinoembryonic antigen, alkaline phosphatase: Regan isoenzyme, creatinekinase: BB-isoenzyme, lactatedehydrogenase: isoenzyme 5) and the data compared to the clinical diagnoses. The sensitivity and specifity of serum-sialyltransferase as a tumor marker is assessed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720358
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    Paper (German National Licenses)
    Fulltext
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