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  • 1
    Electronic Resource
    Electronic Resource
    Hexa- and pentapeptide extension of proalbumin: feedback inhibition of albumin synthesis by its propeptide in isolated hepatocytes and in the cell-free system (1982)
    s.l. : American Chemical Society
    Biochemistry 21 (1982), S. 6053-6059 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00267a005
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  • 2
    Electronic Resource
    Electronic Resource
    An oscillation data collection system for high-resolution protein crystallography (1981)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 37 (1981), S. 701-710 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: An oscillation data collection system for protein crystallography is described. The system consists of a modified Enraf-Nonius precession camera with cylindrical cassette, and stepping motor driven by a flexible microprocessor control system. The X-ray source is graphite-monochromatized radiation from an Elliott GX-21 rotating-anode generator run at 5.5 kW on a focal spot measuring 0.5 × 5.0 mm. The potential advantages of using a relatively large focal spot in conjunction with a graphite monochromator are discussed. Conditions for optimum collimation and X-ray intensity are considered, and it is shown that appropriately designed collimators with adjustable apertures can have substantial advantages over commercially available pinhole collimators. The oscillation films are processed by a procedure based on that of Rossmann [J. Appl. Cryst. (1979), 12, 225-238]. Determination of the initial alignment of the film is facilitated by a pair of reference pins incorporated in the cylindrical cassette. These pins ensure that the position of the film in the cassette is known, and avoid the need for fiducial marks. The crystal alignment and film measurement technique is fully automatic, requiring no prior input other than the approximate starting orientation of the crystal, the approximate unit-cell dimensions, and the angular oscillation range. An alternative method for the determination of crystal orientation is proposed which has been found to be somewhat superior to that of Rossmann, especially for smaller unit cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567739481001587
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  • 3
    Electronic Resource
    Electronic Resource
    A frog with highly evolved sex chromosomes (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 243-245 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Highly differentiated ZZ/ZW sex chromosomes and an exceptionally low genome, size were found in the karyotypes ofPyxicephalus adspersus (Anura, Ranidae). The W-chromosome is considerably smaller than the Z-chromosome and consists to a very great proportion of constitutive heterochromatin. The DNA content of this species and the chromosome length have the lowest values determined in the Ranidae to date.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991633
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  • 4
    Electronic Resource
    Electronic Resource
    Fatal lymphoproliferation and acute monocytic leukemia-like disease following infectious mononucleosis in the elderly (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 477-483 
    Details
    ISSN: 1432-1440
    Keywords: Infectious mononucleosis ; EB virus infection ; Acute monocytic leukemia ; Fatal lymphoproliferation ; Infektiöse Mononukleose ; EB-Virus-Infektion ; akute Monozytenleukämie ; Lymphoproliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über drei ältere Patienten berichtet, bei denen auf serologisch gesicherte, frische infektiöse Mononukleose eine tödlich verlaufende lymphoproliferative Erkrankung (Fall 1), eine akute Leukämie vom monozytären Differenzierungstyp (Fall 2) und eine akute Leukämie von wahrscheinlich monozytärem Differenzierungstyp (Fall 3) folgt.
    Notes: Summary Three elderly patients are reported, in whom serologically confirmed recent infectious mononucleosis is followed by fatal lymphoproliferation (case 1), by acute monocytic leukemia (case 2), and by acute probably monocytic leukemia (case 3).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696209
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  • 5
    Electronic Resource
    Electronic Resource
    Uncommon extensive juxtacortical necrosis of the brain (1982)
    Springer
    Virchows Archiv 397 (1982), S. 355-361 
    Details
    ISSN: 1432-2307
    Keywords: Brain-necrosis ; Juxtacortical ; Coma ; Brain death ; Hyperinsulinism ; Dehydration ; Acidosis ; Adult female
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A previously healthy woman in middle age, vacationing in Spain, is treated with a massive dose of insulin for minimal hyperglycemia following an apparent gastrointestinal disease. This results in rapid coma and, 20 days later, in death. At autopsy, the main finding consists in a remarkable and uncommon ribbon-like juxtacortical necrosis of the white matter in both hemispheres of the telencephalon. There is also a microscopic focal necrosis in the pons cerebri. The grey matter of cortex and basal nuclei, and the subcortical arcuate fibers are spared. The detailed autopsy fails to reveal other essential changes. We have not been able to find reports on an identical case. Hypoglycemic coma usually causes cerebral lesions different from those seen in the present case. A brief analysis of the differential diagnosis is made. In the absence of unequivocal signs of infection, vascular disease or degenerative marks, the findings are tentatively related to complex interactions between fluid loss, hypoglycemic coma, hypoxia and other metabolic disturbances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496576
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  • 6
    Electronic Resource
    Electronic Resource
    Segregation of HLA-DR2 among affected and non-affected offspring of 66 families with Type 1 (insulin-dependent) diabetes (1984)
    Springer
    Diabetologia 27 (1984), S. 80-82 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; haplotypes ; heterogeneity ; HLA-DR2 segregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Segregation of HLA-DR2 among affected and unaffected offspring was studied in 66 HLA-genotyped families with Type 1 diabetes in whom at least one parent carried DR2. The frequency of DR2-positive parents (21%) was not different from that of control families (29%). Among the diabetic probands, the gene frequency of DR2 was significantly decreased compared with control subjects (0.05 versus 0.17, p 〈 0.001) as were DR5 (0.07 versus 0.17, p〈 0.01) and DR7 (0.06 versus 0.13, p〈0.003). Twenty probands carried DR2, in 11 of whom (55%) it was found in combination with either DR3 or DR4. The nine cases who carried another DR allele included one who was DR2 homozygous. Transmission of DR2 was reduced in affected offspring, and random in unaffected siblings, compared with the expected ratio. However, when the DR2 transmission was analysed separately for parents bearing DR2 with DR3, DR4 or another DR allele, it appeared that DR2 transmission to affected offspring was random when the parents carried neither DR3 or DR4, the transmission deficit being due to over-transmission of DR3 and DR4. The haplotype analysis showed that the haplotype A3, Cw7, B7, BfS, DR2, found in 19% of “non-diabetic” DR2 haplotypes was practically absent among “diabetic” DR2-haplotypes (4%). In conclusion, population and segregation analysis could not demonstrate a specific protective effect of DR2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275653
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  • 7
    Electronic Resource
    Electronic Resource
    Genetic polymorphism of the fourth component of complement and type 1 (insulin-dependent) diabetes (1984)
    Springer
    Diabetologia 27 (1984), S. 116-117 
    Details
    ISSN: 1432-0428
    Keywords: HLA ; complement ; Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The complement proteins, Bf, C2, C4A and C4B, are closely linked to HLA. In 74 propositi and their families, and 97 controls genotyped for HLA-A, -B, -C, -DR, -Bf, a high incidence of the C4BQ0 variant was detected in the patient group (33% versus 12%, p〈 0.00001); C4BQ0 was more frequent in propositi than in non-affected siblings (40 out of 74 versus 36 out of 92, p〈0.05). When comparing the distribution of the phenotype C4BQ0 in Type 1 diabetic patients and normal control subjects, the difference was significant in patients bearing DR3 or DR4 (56% and 25%, respectively, p〈 0.003). The main linkage disequilibria were observed among the 74 propositi: B18, BfF1, C4, A3, BQ0, DR3; B12, BfS, C4, A3, BQ0, DR4. The existence of a silent allele at the C4 B locus is known to be associated with a defective immune response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275664
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  • 8
    Electronic Resource
    Electronic Resource
    HLA Genotype studies in juvenile insulin-dependent diabetes (1980)
    Springer
    Diabetologia 19 (1980), S. 189-193 
    Details
    ISSN: 1432-0428
    Keywords: Insulin dependent diabetes ; HLA complex ; DR ; Bf ; DRw3/4 heterozygosity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary HLA genotypes were ascertained in 53 French Caucasian families, comprising 68 juvenile onset insulin-dependent diabetic siblings. Among the 49 alleles detected at different loci in the HLA complex (A, C, B, Bf, DR) 4 appeared to occur at a significantly higher frequency among the 53 index cases than in a control series of 116 healthy individuals: HLA-B18 (p〈10-3), DRw3, DRw4 and BfF1 (p〈10-6). The excess of HLA identical affected siblings confirms genotype disequilibrium and supports the hypothesis of an HLA-linked gene(s) conferring susceptibility. There was no increase of homozygosity for HLA DRw3 and DRw4 whereas there was a marked excess heterozygosity for HLA DRw3/DRw4 in diabetic patients (32% versus 0% in the control series, p〈0.001). These data provide evidence for the existence of two cooperating genes, linked to each of the HLA DR alleles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275267
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  • 9
    Electronic Resource
    Electronic Resource
    Unusual heteromorphic sex chromosomes in a marsupial frog (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 1153-1155 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Heteromorphic sex chromosomes of the XY/XX-type were found in the karyotypes of the South American marsupial frogGastrotheca riobambae (Anura, Hylidae). The Y chromosome is considerably larger than the X chromosome and almost completely heterochromatic. The only nucleolus organizer region is localized in the X chromosome; this leads to a sex-specific difference in the number of nucleolus organizers. In the male meiosis, X- and Y chromosomes form a sex bivalent which can be readily distinguished from the autosomal bivalents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01943157
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  • 10
    Electronic Resource
    Electronic Resource
    Chromosome banding in Amphibia (1982)
    Springer
    Chromosoma 87 (1982), S. 327-344 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The structure of the nucleolus organizer regions (NORs) in mitotic chromosomes, diploid nuclei and spermatogenesis was studied in 260 individual animals from 23 genera of the Anura. The analyses were performed with conventional cytogenetic methods as well as with Ag-staining, GC- and AT-specific fluorochromes (mithramycin, chromomycin A3, quinacrine) and C-banding. Most of the species have only one pair of NORs in their karyotypes. The majority of individuals of all species exhibited considerable differences in the sizes of their homologous NORs. Most of these heteromorphisms are due to tandem duplications or triplications in one of the two NORs. However, duplicated or triplicated NORs never occur in a homozygous form, but are instead always in combination with a normal-structured NOR in the homologous chromosome. In three animals, a complete deletion of one NOR and its closely associated constitutive heterochromatin was determined. The cytochemistry of the specific NOR-stainings are discussed. The size differences of the Ag-, mithramycin- and chromomycin A3-stained NORs can be traced to differences in the rDNA content in these NORs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327634
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