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  • 1975-1979  (3)
  • 1965-1969  (2)
  • 1960-1964  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    Submerged Citric Acid Fermentation of Sugar Beet Molasses. Effect of Ferrocyanide Control (1962)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 1 (1962), S. 59-62 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i360001a013
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Non-penetrating trauma to the carotid artery with secondary thrombosis and embolism: Treatment by Thrombolysin (1977)
    Springer
    Acta neurochirurgica 37 (1977), S. 219-244 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of partially occluding post-traumatic thrombosis of the internal carotid artery and secondary embolism of the middle cerebral artery is reported. The patient was treated with Thrombolysin with coincident resolution of clinical symptoms and signs and clearing of the lesions on arteriography. This may have been fortuitous. The subject of traumatic carotid artery thrombosis is reviewed in detail, and its pathophysiology is discussed, especially in relation to facts known about occlusive vascular disease secondary to atherosclerosis and related embolie phenomena. Suggestions are made concerning the treatment of this condition, especially with regard to developing rational criteria for opening vascular beds through evaluation of collateral cerebral blood flow. The uses of microvascular surgical techniques and thrombolytic therapy are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402128
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Heat precipitation of poly (γ-hydroxy-L-proline) (1978)
    New York : Wiley-Blackwell
    Biopolymers 17 (1978), S. 1381-1384 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1978.360170521
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Aeration in tower-type fermentors: Effect of tower diameter and number of aeration disksContribution No. 6866, from the Division of Applied Biology, National Research Council, Ottawa, Canada (1962)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 4 (1962), S. 241-245 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The rate of oxygen absorption by aqueous sodium sulphite solutions in tower-type fermentors up to 6 in. in diameter was related both to tower diameter and to the number of sintered Pyrex disks used for dispersing air entering the towers. Maximal rates of absorption were obtained in towers 2.5 in. in diameter. Under comparable conditions, rates of oxygen transfer in towers containing one aeration disk were approximately 30% higher than those in similar towers containing two or more disks. In towers greater than 6 in. in diameter, the absorption rate was independent of vessel diameter and number of aeration disks when more than one disk was used. Bubble coalescence was the main cause of the difference in the rate of oxygen absorption.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260040214
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  • 5
    Electronic Resource
    Electronic Resource
    Uniform inoculation of nutrient surfacesContribution from the Division of Applied Biology, National Research Council, Ottawa, Canada. Issued as N.R.C. No. 7650. (1963)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 5 (1963), S. 123-129 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A method of inoculating nutrient surfaces uniformly with bacterial cells has been developed. The method is based on controlled exposure of samples in a humidified chamber to a spray produced from a bacterial suspension. Factors affecting uniformity of inoculation (ionic strength of suspension, force of spray, distance between spray nozzle and sample, and exposure time) were studied in detail. Under optimum condition using agar medium in Petri plates, differences between total counts for six plates inoculated simultaneously, or between counts for individual 2 cm.2 areas taken at any location on any of the plates, were not statistically significant at the 5% level. The coefficient of variability for counts on 2 cm.2 areas renged from 8 to 12% between tests of 216 counts each.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260050208
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of manganese and other heavy metals on submerged citric acid fermentation of molasses (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 8 (1966), S. 465-471 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The addition of as little as 2 ppb of manganese to ferrocyanide-treated beet molasses during citric acid fermentation by Aspergillus niger NRC A-1-233 caused a 10% reduction in acid yield and undesirable change in the morphology of the organism from the normal pelletlike form to the filamentous from. Still smaller additions (0.4-2ppb) caused undesirable pellet clumping, while greater additions (2-100 ppb) gave further decreases in yield. The yield obtained at 100 ppb was less than 25% of that obtained at 1 ppb or less. None of the other metals tested (Al3+, Ca2+, Co2+, Cu2+, Fe2+, Mg2+, Ni2+, Zn2+) visibly changed pellet morphology, and only Al3+, Fe2+, and Zn2+ at relatively higher concentrations (5-25ppm) reduced acid yield. The adverse effect of manganese on growth and acid production was not affected by addition of the other metals.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260080402
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  • 7
    Electronic Resource
    Electronic Resource
    Submerged citric acid fermentation of beet molasses in tank-type fermentersIssued as N.R.C. No. 7672. (1963)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 5 (1963), S. 193-199 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Ferrocyanide-treated beet molasses was fermented in fully baffled mechanically agitated, 2.5-liter, tank-type fermenters using pellets of Aspergillus niger grown in shake flasks as an inoculum. The object of the study was to adapt the fermentation method previously developed in an unstirred tower-type fermenter to a conventional tank-type fermenter. Under selected conditions of stirring (agitator speed 400-700 rpm) and sparging (medium porosity sintered disk), high yields of citric acid (8.6% citric acid, 70% conversion of available sugar) were obtained in 140 hr. of fermentation. There was little relation between citric acid yield and aeration conditions in the fermenter as judged by mash viscosity measurements and sulfite oxidation studies.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260050304
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  • 8
    Electronic Resource
    Electronic Resource
    Submerged citric acid fermentation of ferrocyanide-treated cane molassesContribution from the Division of Applied Biology, National Research Council, Ottawa 2, Canada. Issued as N.R.C. No. 6722 (1962)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 4 (1962), S. 17-21 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Ferrocyanide-treated cane molasses was fermented in 2.5-l. Pyrex tower fermenters using pellets of Aspergillus niger, grown in beet molasses, as an inoculum. The success of the process depended on accurate control of the ferrocyanide concentration in the fermentation mash. Highest yields (up to 80% conversion of available sugar in 8 days) were obtained when the ferrocyanide concentration was 20 p.p.m. at the start of fermentation and then increased to 80-150 p.p.m. at the 24-hr. period. Addition of phosphate, nitrate, or methanol to fermentation mash did not increase rate of acid production or final yield.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260040104
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of potassium ferrocyanide on the chemical composition of molasses mash used in the citric acid fermentationIssued as N.R.C. No. 8405. (1965)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 7 (1965), S. 269-278 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The addition of potassium ferrocyanide to the molasses substrate (mash) used in the citric acid fermentation had little or no effect on the total carbon, nitrogen, or phosphorus content of the substrate but reduced the ash content by 1-4% depending on the type and crop year of molasses. Eighteen of the 21 metals identified in beet molasses by spectrographic analysis were precipitated in part by the treatment. The metals known to interfere with citric acid production, particularly manganese and iron, were those most efficiently precipitated. At mash temperatures of 80°C. and approximately 100°C., precipitation was completed within 15 min. after ferrocyanide addition and the reductions in the soluble mineral content in each case were similar. At 25°C. the precipitation reactions occurred but required more than 50 hr. to complete. Significantly more total mineral and more iron, calcium, and copper were precipitated at pHs 4 and 6 than at pH 8; manganese precipitation, however, was not affected by these pH changes.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260070206
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of collagen crosslinking on the rate of resorption of implanted collagen tubing in rabbits (1977)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 11 (1977), S. 297-314 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Collagen tubes were tanned with glutaraldehyde for different periods of time. Some were oxidized with periodate and sterilized with either 60Co (1.5 Mrad) or propylene oxide. The tubes were coated with polyfilamentous polyester fabric, filled with x-ray contrast material, and implanted subcutaneously in rats and rabbits. Rate of resorption was ascertained by x-ray procedure of progressive leakage of contrast material.A close relation between tanning time of the collagen fabric-combined prostheses and rate of their resorption in subcutis was found in both rats and rabbits. In rabbits, however, the implants were resorbed at a significantly faster rate than in rats. No effect of oxidation of collagen on the resorption was observed. Collagen tubes tanned for shorter time periods and sterilized with propylene oxide were more resistant to degradation than those sterilized with irradiation. This difference was absent, however, with material tanned for longer times.The mechanism of resorption of implanted collagen tubes was studied by morphological methods. The role of inflammatory cells in resorption is documented. The paper indicates the advantages as well as limits of the x-ray method of studying the resorption rate of biodegradable materials.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820110213
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