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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 367 (1976), S. 115-122 
    ISSN: 1432-2013
    Keywords: Mouse neuromuscular junction ; ACh-receptor ; Noise analysis ; Cooperativity ; Junctional and extrajunctional ACh-sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Muscles from cats, rats, guinea pigs and mice have been investigated as preparations for visualizing mammalian neuromuscular junctions with the aid of Nomarski interference optics. The M. omohyoideus of the mouse was found to be most convenient. Electrophysiological investigations showed that an endplate is normally surrounded by a population of perijunctional receptors. For junctional receptors in the endplate, a Hill coefficient ofn H=2.6 for acetylcholine was determined at 38°C, decreasing to a value of 2.3 at room temperature. For both perijunctional and extrajunctional receptors (the latter occurring after denervation), the coefficientn H was 1.9. Noise analysis revealed a channel conductance γ which changed abruptly from 22.4±1.0 pS (10–23°C) to 45.6±0.9 pS (34–39°C) in a very small temperature range around 25.5°C. The mean channel lifetime τ was 0.3 ms at 39°C and 1.0 ms at 23°C.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 55 (1977), S. 323-327 
    ISSN: 1432-1440
    Keywords: Platelet morphology ; Platelet aggregation test ; Physical training of athletes ; Standardised ergometry ; Thrombocytenmorphologie ; Plättchenaggregationstest ; Körperlicher Trainingszustand ; Standardisierte Ergometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über morphologische Strukturanalysen der Thrombocyten unter körperlicher Belastung bei unterschiedlichem Trainingszustand berichtet. Die Untersuchungen wurden an 3 Probandengruppen zu je 15 Personen durchgeführt. Gruppe X bestand aus 15 Personen im Alter von 20–26 Jahren mit gelegentlicher Gymnastik, Gruppe Y umfaßte 15 Probanden im Alter von 44–52 Jahren ohne wesentliches körperliches Training, und Gruppe Z enthielt 15 Leistungssportler im Alter von 22–25 Jahren. Die Thrombocytenveränderungen wurden nach dem Plättchenaggregationstest (PAT) in 5 Stufen eingeteilt: Solitärstadium (Stufe I), Akkumulationsstadium (Stufe II), Degranulationsstadium (Stufe III), Stadium der Fibrinbildung (Stufe IV), und Stadium der irreversiblen Aggregation (Stufe V). Nach dosierter Ergometerbelastung waren bei allen Probanden in Blutausstrichen eine Reduktion des Solitärstadiums und ein Anstieg der PAT-Stufen II–V zu ermitteln, mit Ausnahme der Leistungssportler. In Erholungsphasen von 5, 30 und 60 min nach der Belastung war eine deutlich verzögerte Rückkehr irreversibler Aggregate (PAT V), der Plättchenveränderungen im Stadium der Fibrinbildung (PAT IV), und des Degranulationsstadiums bei der Gruppe untrainierter älterer Probanden im Vergleich zu den Leistungssportlern nachweisbar. Die Untersuchungen könnten eine mögliche Erklärung für akute thrombotische Herztodesfälle bei Leistungssportlern sein. Sie sprechen andererseits aber für eine bessere Adaptation des thrombocytären Systems unter körperlicher Belastung bei guter organischer Leistungsfähigkeit Sporttreibender.
    Notes: Summary The morphology of thrombocytes of 45 volunteers in varying conditions of training was analysed under physical stress. The probands were divided in three groups of 15 each. Group X (aged 20–26 years) had occasional gymnastics training. Group Y (aged 44–52 years) was without any physical training, and Group Z consisted of athletes (aged 22–25 years) in good training condition. By means of the platelet aggregation test (PAT), thrombocyte changes were classified in 5 stages: solitary stage (I), accumulation stage (II), degranulation stage (III), fibrin forming stage (IV), irreversible aggregation stage (V). The probands were subjected to ergometer stress in exact dosage. With the exception of the athletes, all blood smears showed a decrease in stage I (solitary), and considerable increase in stages II–V. 5, 30, or 60 min after stress, the return of irreversible aggregates (PAT V), of platelet changes in the fibrin-forming stage (PAT IV), and in the degranulation stage (PAT III), was markedly delayed in Group Y (untrained older persons) when compared with the group of well-trained athletes. The observation may offer an explanation for some cases of acute thrombotic cardiac death among trained athletes. On the other hand, it may prove the better adaptation of the thrombocytic system during physical stress when athletes are in good physical condition.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 55 (1977), S. 539-543 
    ISSN: 1432-1440
    Keywords: Dysfibrinogenemia ; Fibrin polymerization defect ; Bleeding disorder ; Dysfibrinogenämie ; Fibrinpolymerisationsstörung ; Hämostasestörung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über einen neuen Fall von Dysfibrinogenämie berichtet. Der genetische Moleküldefekt hat keine manifeste hämorrhagische Diathese zur Folge, sondern zeigt sich lediglich in diskreten Veränderungen der gerinnungsanalytischen Parameter (verlängerte Thrombin-, Reptilase- und Thrombinkoagulasezeit; erniedrigter Wert des thrombingerinnbaren Proteins im Vergleich zum Ergebnis der immunologischen Fibrinogenbestimmung; verzögerter Verlauf der Fibrinpolymerisation). Darüberhinaus werden Klinik und Diagnostik der Dysfibrinogenämie zusammenfassend dargestellt.
    Notes: Summary A new case of dysfibrinogenemia is reported which shows no signs of a haemorrhagic diathesis (dysfibrinogenemia Gießen III). The abnormal fibrinogen was detected by only slight but characteristic alterations of some parameter of the coagulation analysis (prolonged clotting times after addition of thrombin, Reptilase and thrombin coagulase; low fibrinogen concentration determined by methods based on clot formation in comparison to the immunological fibrinogen determination; delayed fibrin polymerization). In addition, clinical features and diagnosis of dysfibrinogenemia are described in general.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 111 (1976), S. 209-219 
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Light-dependent motor activity and phototactic behavior was investigated in 1) untreated, 2) blinded, and 3) blinded and pinealectomized eels (Anguilla anguilla L.). Neither blinding nor blinding combined with pinealectomy interfered with the observed nocturnal motor activity or the photonegative behavior characteristic for the untreated animals. However, an aluminum foil covering the skull of blinded animals altered the light-dependent motor activity pattern in contrast to blinded animals bearing a transparent plastic foil cover. Blinded animals with an aluminum foil covering the brain case exhibited a motor activity pattern resembling arrhythmicity. The motor activity pattern of 1) untreated, 2) blinded, as well as 3) blinded and pinealectomized eels followed an inversed light regime with a latency of about two days indicating that in the eel light is the dominatingZeitgeber triggering circadian motor activity patterns. The reported findings speak in favor of the existence of photosensitive areas in addition to the lateral eyes and the epiphysis cerebri. From the results of the covering experiments it is clear that these unknown photoreceptor sites must be located in the brain.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 63 (1976), S. 49-50 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 66 (1979), S. 108-109 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 83 (1975), S. 197-214 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die beiden grundsätzlich unterschiedlichen Total-Endoprothesen für das Kniegelenk — „Scharnier“-Endoprothesen und „Schlitten“- bzw. „Kufen“-Endoprothesen — werden hinsichtlich Konstruktion und Fähigkeit zur Aufnahme bzw. Übertragung von Kräften und Momenten vergleichend behandelt und die Unterschiede zum natürlichen Kniegelenk skizziert. Die konstruktiv bedingten Rückwirkungen auf die Verankerung der Endoprothesen im Knochen werden herausgestellt. An Hand einer systematischen Analyse der sogenannten „Schlittenprothesen“ wird gezeigt, daß zwischen echten „Schlittenprothesen“, die über Bewegungsmöglichkeiten zur Rotation und Translation verfügen und „Pseudo-Schlittenprothesen“ (besser „Rotations-Segment“-Prothesen), die nur eine Rotationsmöglichkeit zum Realisieren der Kniebeugung erlauben, unterschieden werden muß. Als kennzeichnendes Unterscheidungsmerkmal zwischen den unterschiedlichen Endoprothesen-Prinzipien und deren Varianten dienen Art und Anzahl der vorhandenen „Freiheitsgrade“. Die Arbeit soll in erster Linie zu einem systematischen „Leistungsvergleich“ unterschiedlicher Bauarten von Kniegelenksendoprothesen anregen, damit dem Operateur auf längere Sicht eine objektive Entscheidungshilfe an die Hand gegeben werden kann.
    Notes: Summary The two completely different total knee-endoprostheses (hinge type and sled or runner type) have been compared concerning construction and ability for take up or transmission of forces and moments. The difference to the real knee joint are described. The reactions on fixing of endoprostheses in the bone caused by the construction are emphasized. By a systematic analysis of the so called sled-prostheses is to be shown to differantiate between real sled-prostheses with rotation and sliding mobility and pseudo-sled-prostheses (better rotation-segment-prostheses). They have only one possibility of rotation to realize the knee bending. The kind and number of existing “degrees of freedom” are used as a significant characteristic to differentiate the various endoprostheses principles and their variants. This study should mainly inspirate for a systematic comparison of efficiency of the different types of knee-endoprostheses. This should give the operating surgeon for a length of time an objective aid to decision.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 94 (1979), S. 299-312 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Stabilisierung der infizierten Femur-Pseudarthrose ist unabhängig von der ossären Abstützung bei gegebener Indikation die ausreichend dimensionierte Platten-Osteosynthese anderen Verfahren vorzuziehen. Andernfalls ist der Fixateur externe indiziert. Seineerfordert am Oberschenkel spezielle Kenntnisse, die sich an den individuellen Knochen- and Weichteilbefunden orientieren. Wir unterscheiden den Oberschenkel-Fixateur Typ I bis IV, welche an Modellen and Behandlungsbeispielen vorgestellt werden. Die Komplikationen werden zunächst vom Blutverlust and der Infektaktivität, später durch chronische Weichteilfisteln, Abszesse, osteomyelitischer Resthöhlen and Spontanfrakturen bestimmt. Die Behandlung und Spätergebnisse von 96 infizierten Femur-Pseudarthrosen werden dargestellt.
    Notes: Summary Indications given, the adequately dimensioned plate osteosynthesis must be preferred to any other treatment for stabilizing an infected femur pseudarthrosis, regardless of the osseous support. Otherwise the fixateur externe is indicated. Its assembly on the upper leg requires a special knowledge which reflects the individual bone- and soft-tissue-assessments. We distinguish between fixateur type I to IV on the upper leg, all of which are exemplified. Complications are at first mainly loss of blood and infective activity, later chronic soft-tissue fistulae, abscesses, osteomyelitic residual cavities, and spontaneous fractures. A study analyses the treatment and the late results of 96 infected femur pseudarthroses.
    Type of Medium: Electronic Resource
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  • 9
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    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 27:9 (1979) 1102 
    ISSN: 0012-1045
    Topics: Philosophy
    Description / Table of Contents: BEMERKUNGEN UND BERICHTE
    Notes: Zum 30. Jahrestag der Gründung der DDR
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 14 (1977), S. 283-287 
    ISSN: 1432-0630
    Keywords: 79.20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract TheL 2,3 VV Auger transitions of Si, SiO2, and SiC have been measured and compared with the self-fold electron density of states. The data indicate that Auger matrix effects must be included to explain the structure of the Auger lines. A comparison with soft X-ray measurements of Wiech shows, that the measured Auger line shape is nearly identical with the self-foldK β emission band. The selection rules for X-ray emission lead then to the conclusion that mostlyp-like valence electrons are involved in the Auger transition. This result indicates the relative importance ofs andp states in Auger transitions which is in accordance with theoretical calculations of Feibelman et al.
    Type of Medium: Electronic Resource
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