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  • 1
    Electronic Resource
    Electronic Resource
    Hämorheologie und Akute Phase Reaktion nach Thrombendarteriektomie der extracraniellen Arteria carotis (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 379-384 
    Details
    ISSN: 1432-1440
    Keywords: Hemorheology ; Acute Phase Proteins ; Vascular Surgery ; Carotid Arteries ; Arterial Occlusive Diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 39 patients with hemodynamically significant stenoses of the internal carotid artery thrombendarterectomy was performed. Hemorheological properties and plasma protein levels were studied pre- and postoperatively over a period of 14 days. In comparison to age-matched healthy controls preoperative plasma viscosity, red cell aggregation, fibrinogen, haptoglobin and alpha-1-antitrypsin were significantly elevated. After surgical trauma there was an increase in fibrinogen, alpha-1-antitrypsin, haptoglobin and ceruloplasmin, whereas alpha-2-macroglobulin, immunglobulin A and immunglobulin G decreased significantly. Plasma viscosity, red cell aggregation, red cell filterability, fibronectin and immunglobulin M remained unchanged. We conclude that our patients showed a non specific chronic “hematological stress syndrome” with raised acute phase reactants and corresponding hemorheological changes preoperatively; despite postoperative acute phase reaction no further deterioration of the rheological parameters could be observed; this might be caused by a decrease of plasma proteins with high frictional ratios compensating the increase of acute phase proteins. Besides, tissue damage and consecutive acute phase reaction in carotid arterial surgery seem to be of relatively minor degree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737940
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  • 2
    Electronic Resource
    Electronic Resource
    Tolerance of high doses of amphotericin B by infusion of a liposomal formulation in children with cancer (1994)
    Springer
    Annals of hematology 68 (1994), S. 27-31 
    Details
    ISSN: 1432-0584
    Keywords: Liposomal amphotericin B ; Granulocytopenia ; Cancer ; Children ; Tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Conventional amphotericin B (Amph-B) is the drug of choice for treating systemic fungal infections. Recently, a new formulation has become available, encapsulated in liposomes (Amph-lip). This new form of administration was developed in order to lower the acute side effects and to offer the possibility of administering high doses of amphotericin B. Experience with Amph-lip is limited, especially in children. We treated four children with documented systemic fungal infections with Amph-lip and administered it empirically to 12 children. Fifteen of these 16 children were severely granulocytopenic oncologic patients. One 3-month-old baby suffered from systemic candidiasis. Amph-lip was preferred to conventional Amph-B in children with organ dysfunction developing as a consequence of conventional chemotherapy or bone marrow transplantation, after failure of conventional Amph-B to improve a fungal infection, and after adverse drug reactions had occurred. The daily doses of Amph-lip ranged from 1 to 6 mg/kg (median 3 mg/kg), the cumulative doses from 13 to 311 mg/kg (median 75 mg/kg). Acute adverse reactions or organ function abnormalities attributable to Amph-lip did not occur in 402 administrations. Amph-lip has proven to be well tolerated by children in terms of acute toxicity and in the long term. Although large cumulative doses were given, organ function abnormalities attributable to Amph-lip doses were not detected in any of ten long-term survivors over a median observation time of 36 months (range 30–44 months). Amph-lip appears to be a promising alternative antifungal treatment, especially for patients with impaired organ function, when high doses of amphotericin B are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695916
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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