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  • Acute aneurysmal surgery  (1)
  • Anti-phospholipid antibodies  (1)
  • Euphorbia supina  (1)
  • Euphorbiaceae  (1)
  • Key words: IL-18 - IL-12 - Histidine decarboxylase - Histamine  (1)
  • Keywords: Vasa vasorum; intracranial artery; atherosclerosis; intramural haemorrhage.  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    17β,21β-Epoxyhopan-3β-ol and β-alnincanol from Euphorbia supina
    Amsterdam : Elsevier
    Phytochemistry 29 (1990), S. 2253-2256 
    Details
    ISSN: 0031-9422
    Schlagwort(e): 17β,21β-epoxyhopan-3β-ol ; Euphorbia supina ; Euphorbiaceae ; sterols ; triterpenes ; whole herb ; β-alnincanol.
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(90)83047-5
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Vasa Vasorum of the Intracranial Arteries (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 411-416 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Keywords: Vasa vasorum; intracranial artery; atherosclerosis; intramural haemorrhage.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Most of the major extracranial arteries have vasa vasorum which play an important role in some pathological conditions. However, in the intracranial arteries, the existence of vasa vasorum and their pathological implication have not been adequately investigated. We examined the distribution and incidence of vasa vasorum in the major cerebral arteries and their relationships to certain clinical factors in 50 autopsy cases performed between 1987 and 1994. By light microscopy, vasa vasorum were found in 36 of 50 patients. Of 36 patients, vasa vasorum in 30 cases were localizedly observed in the tunica adventitia and the in other 6 were distributed in the tunica media accompanied by intramural haemorrhage. Existence of vasa vasorum was more common in the proximal arteries (vertebral, internal carotid, and basilar arteries) than in the distal arteries (middle cerebral and anterior cerebral arteries). Vasa vasorum were found more frequently in aged patients with severe atherosclerosis and those with cerebrovascular diseases. Our results indicated that intracranial vasa vasorum existed with a higher frequency in the tunica adventitia of the vertebral and internal cerebral arteries, and the incidence of vasa vasorum related to severity of atherosclerosis. The development of vasa vasorum in the tunica media may reflect some pathological changes of cerebral arteries.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007010050118
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  • 3
    Digitale Medien
    Digitale Medien
    Induction of the activity of the histamine-forming enzyme, histidine decarboxylase, in mice by IL-18 and by IL-18 plus IL-12 (2000)
    Springer
    Inflammation research 49 (2000), S. 513-519 
    Details
    ISSN: 1420-908X
    Schlagwort(e): Key words: IL-18 - IL-12 - Histidine decarboxylase - Histamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: Objective and Design: IL-18 shares functional properties with IL-12, which induces an elevation of histidine decarboxylase (HDC) activity in mouse tissues. Therefore, we examined the effects of IL-18 and IL-18+IL-12 on HDC activity.¶Methods: IL-18, IL-12 or IL-18+IL-12 was intraperitoneally injected into BALB/c and C3H/HeN mice and their HDC activities were measured.¶Results: IL-18, at effective antitumour doses, induced HDC activity in lung, liver, spleen and bone. The IL-18-induced HDC elevation was more rapid than that induced by IL-12. As with IL-12, repeated injections of IL-18 produced more HDC activity than a single injection. Repeated injections of IL-18+IL-12 induced serious illness and produced marked HDC activity. However, an inhibitor of HDC did not prevent the illness.¶Conclusions: IL-18 may be involved in the stimulation of histamine synthesis during the course of immune responses, though an elevation of HDC activity is not itself the direct cause of the serious illness induced by IL-18+IL-12.¶
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s000110050624
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  • 4
    Digitale Medien
    Digitale Medien
    Platelet-activating factor and antiphospholipid antibodies in subarachnoid haemorrhage (1994)
    Springer
    Acta neurochirurgica 128 (1994), S. 144-149 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Anti-phospholipid antibodies ; platelet-activating factor ; PAF-acetylhydrolase ; subarachnoid haemorrhage
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The purpose of this study was to measure plasma platelet-activating factor (PAF) concentration, PAF-acetylhydrolase activities, anti-phospholipid antibody (aPLs) titers, and platelet function in patients with subarachnoid haemorrhage (SAH) and to assess the association of these variables with the development of cerebral vasospasm. Thirty-two patients with SAH due to ruptured cerebral aneurysm were studied. Plasma PAF concentration, PAF-acetylhydrolase activity, platelet count and aggregability, and plasma factor 4 (PF 4) concentrations were measured regularly until approximately 2 weeks after SAH. aPLs, including lupus anticoagulant and anti-cardiolipin IgG and IgM were measured within 3 days after SAH. Plasma PAF concentration in patients with SAH showed the highest value on the occasion during 5 to 9 days after SAH. The concentrations were higher in patients with infarction due to vasospasm than in patients without cerebral infarction on any occasions after SAH. Plasma PAF-acetylhydrolase activities did not change in patients, regardless of the presence of cerebral infarction after SAH. Increased platelet consumption and aggregability and higher concentrations of PF 4 were detected in patients with cerebral infarction and not in patients without cerebral infarction. The patients with cerebral infarction due to cerebral vasospasm had aPLs more frequently than the control volunteers. Our findings indicate that increased plasma PAF and aPLs may contribute to the pathogenesis of cerebral vasospasm after SAH.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01400665
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  • 5
    Digitale Medien
    Digitale Medien
    The use of computed tomography in the prediction of delayed cerebral infarction following acute aneurysm surgery for subarachnoid haemorrhage (1995)
    Springer
    Acta neurochirurgica 132 (1995), S. 9-13 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Acute aneurysmal surgery ; cerebral infarction ; cerebral vasospasm ; computed tomography ; subarachnoid haemorrhage
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to predict the occurrence of cerebral infarction after aneurysmal surgery in patients with subarachnoid haemorrhage, we measured the amount of subarachnoid blood on initial and on post-operative computed tomograms. We used a reliable grading method to estimate the amount of blood on computed tomograms in 24 patients with infarction due to vasospasm and 45 patients without cerebral infarction, all of whom underwent aneurysmal surgery within 48 hours after the ictus. The total amount of subarachnoid blood on admission and on the day after operation was more in the cerebral infarction group than in the non-infarction group. The clearance rate of subarachnoid blood by surgery was lower in patients with cerebral infarction than in patients without infarction and the predominant site of subarachnoid blood corresponded with the site of the infarct. Of 24 patients with cerebral infarction, 22 (92%) belonged to the group whose initial total blood score was more than 10 on admission and whose clearance rate by surgery was less than 50%. Therefore, we propose this range to be an indication for the occurrence of cerebral infarction in postoperative patients due to cerebral vasospasm. The presence of intracerebral haematoma and the amount of ventricular blood and their clearance by surgery were also estimated for the prediction of delayed cerebral infarction after aneurysmal surgery. However, they had no relation to the occurrence of cerebral infarction due to vasospasm.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01404841
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