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  • Local tetanus  (2)
  • Alkylating agents  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Roles of two types of O^6-methylguanine-DNA methyltransferases in DNA repair
    Amsterdam : Elsevier
    Mutation Research/DNA Repair 254 (1991), S. 37-44 
    Details
    ISSN: 0921-8777
    Schlagwort(e): Alkylating agents ; Cell survival ; DNA repair ; Mutation frequency ; O^6-Methylguanine-DNA methyltransferase
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-8777(91)90038-Q
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of tetanus toxin on the monosynaptic reflex (1983)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 323 (1983), S. 217-220 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Tetanus toxin ; Local tetanus ; Spinal cord ; Monosynaptic reflex
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Tetanus toxin was injected at various doses (0.1–10,000 mouse MLD/kg) into the gastrocnemius muscle of the left hind leg of the cat. The relative excitability of the monosynaptic reflex (MSR) was increased in the very early period of the intoxication decreased in the later period, during which the MSR of the gastrocnemius was either partially or totally depressed at doses as low as 10 mouse MLD/kg.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00497666
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  • 3
    Digitale Medien
    Digitale Medien
    Tetanus toxin induced actions on spinal Renshaw cells and Ia-inhibitory interneurones during development of local tetanus in the cat (1977)
    Springer
    Experimental brain research 27 (1977), S. 271-286 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Local tetanus ; Spinal interneurones ; Spinal inhibitions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In anaesthetized cats the activities of Renshaw cells (RCs) and Ia-inhibitory interneurones (IaINs) were recorded during the accumulation of tetanus toxin in the spinal cord following injection into the gastrocnemius muscle. The early response of the RCs increased during the period of development of local tetanus. With some cells there was a subsequent decrease in the early response in later periods of the observation time (16–44 hrs after intramuscular injection). The effects on the spontaneous activity of the RCs were in good correspondence to those on the early response. The hyperactivity of the RCs is proposed to be mediated mainly via disinhibited cholinergic gamma-motoneurones using muscarinic postsynaptic receptors. The “pause” which follows the early response and the recurrent inhibition of IaINs was not reduced during the development of local tetanus. These results indicate that the central action of tetanus toxin in local tetanus does not consist of a general loss of postsynaptic inhibition. It is suggested that tetanus toxin acts mainly on synaptic elements of the alpha- and gamma-motoneurones or on presynaptic nerve terminals in their vicinity. In later periods a disturbing influence on the cholinergic transmission at Renshaw cells seems to occur.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00235503
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