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  • Column liquid chromatography  (6)
  • Allele frequency  (1)
  • Cerebellar nuclei  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A Korean population study of the nine STR loci FGA, VWA, D3S1358, D18S51, D21S11, D8S1179, D7S820, D13S317 and D5S818 (2000)
    Springer
    International journal of legal medicine 114 (2000), S. 41-44 
    Details
    ISSN: 1437-1596
    Keywords: Key words STR ; Allele frequency ; Korea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract DNA typing was performed on 379 randomly selected unrelated Koreans using the nine short tandem repeat loci FGA, VWA, D3S1358, D18S51, D21S11, D8S1179, D7S820, D13S317 and D5S818 present in the AmpFlSTR Profiler Plus PCR amplification kit. Allele frequencies, heterozygosity, power of discrimination, mean exclusion chance, and polymorphism information content of each locus were calculated by statistical analysis. All nine loci were in Hardy-Weinberg equilibrium. The combined discrimination index and the combined mean exclusion chance in Koreans was 2.31 × 10–12 and 0.99983, respectively. By evaluation of 297 children from 128 families, 2 mutations were found at the FGA locus and 1 each at the D18S51 and D13S317 loci. This study demonstrates that this multiplex system is a useful and convenient tool for forensic identification and parentage testing in Korea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140000137
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  • 2
    Electronic Resource
    Electronic Resource
    Simultaneous determination of cefoxitin, cefuroxime, cephalexin and cephaloridine in plasma using HPLC and a column-switching technique (1990)
    Springer
    Chromatographia 30 (1990), S. 80-84 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Cephalosporins ; Column switching in HPLC ; On-line plasma sample clean-up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A new high performance liquid chromatographic method was developed using a column-switching technique for the simultaneous determination of cephalexin, cefuroxime, cefoxitin and cephaloridine in plasma. The plasma samples were injected onto a precolumn packed with Corasil RP C18 (37–50 μm) after simple dilution with an internal standard solution in 0.01 M acetate buffer (pH 3.5). Polar plasma components were washed out using 0.01 M acetate buffer (pH 3.5). After valve switching, the concentrated drugs were desorbed in back-flush mode and separated on a Partisil ODS-3 column using acetonitrile in 0.02 M acetate buffer (pH 4.3) (15∶85, v/v) as the mobile phase. The method showed excellent precision with good sensitivity and speed with a detection limit of 0.5 μg/ml. The total analysis time per sample was less than 25 min, and the mean coefficients of variation for intra- and inter-assay were both less than 4.9 %. This method has been successfully applied to plasma from rats after subcutaneous injection of cefuroxime.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02270453
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    High-performance liquid chromatographic determination of meropenem in rat plasma using column-switching (1996)
    Springer
    Chromatographia 42 (1996), S. 405-408 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Meropenem in rat plasma ; Column-switching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The purpose of this study was to develop a columnswitching HPLC method for the determination of meropenem in plasma. This method showed excellent precision and accuracy with good sensitivity and speed. The total analysis time per sample was less than 20 min and the mean coefficients of variation for intra- and inter-assay were less than 4.0%. The method has been successfully applied to plasma samples from rats receiving an intraperitoneal injection of meropenem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272131
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  • 4
    Electronic Resource
    Electronic Resource
    Simultaneous determination of parathion and metabolites in serum by HPLC with column switching (1997)
    Springer
    Chromatographia 44 (1997), S. 473-476 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Column-switching ; Parathion, and metabolites in serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A new high-performance liquid chromatographic method with column-switching has been developed for the simultaneous determination of parathion and its metabolites such asp-nitrophenol and paraoxon in serum. Serum samples were injected onto a precolumn packed with LiChroprep RP-8 after simple dilution with 20% phosphoric acid. Polar plasma components were washed with 0.02 M phosphate buffer (pH 3.0). After valve switching, the concentrated compounds were eluted in back-flush mode and separated on a Ultracarb ODS 30 column with a gradient of acetonitrile −0.01 M phosphate buffer (pH 3.0) as mobile phase. The method showed excellent precision, accuracy and speed with detection limit of 0.1 μg mL−1. Total analysis time per sample was 〈40 min and coefficients of variation for intra-and inter-assay were 〈4.5%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02466739
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  • 5
    Electronic Resource
    Electronic Resource
    Simultaneous determination of Ibuproxam and Ibuprofen in human plasma by HPLC with column switching (1993)
    Springer
    Chromatographia 37 (1993), S. 618-622 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Ibuproxam and Ibuprofen in plasma ; Column switching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A new high-performance liquid chromatographic method with column switching has been developed for the simultaneous determination of Ibuproxam and its metabolite Ibuprofen in plasma. The plasma samples were injected onto a LiChrosorb RP-8 precolumn after dilution with an internal standard solution in phosphoric acid. Polar plasma components were eluted with 0.05 M phosphoric acid. After valve switching, the concentrated drugs were eluted in the back-flush mode and separated on an Inertsil ODS-2-column with acetonitrile-methanolphosphate buffer as mobile phase. The method showed excellent precision, accuracy and speed with detection limit of 0.1 μg ml−1. Total analysis time per sample was less than 30 min and the coefficients of variation for intra and inter-assay were less than 3.5%. This method has been successfully applied to plasma samples from human volunteers after oral administration of Ibuproxam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274112
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of triethylamine in the mobile phase on the retention properties of conventional polymeric and horizontally polymerized octadecylsilica in RPLC (1999)
    Springer
    Chromatographia 49 (1999), S. 635-642 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Interaction of mobile and stationary phases ; Linear solvation energy relationships ; Triethylamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The effect of triethylamine (TEA) in the mobile phase on the RPLC retention behavior of small organic solutes has been studied on a conventional polymeric octadecylsilica (ODS) and on a horizontally polymerized ODS. Retention factors for a set of solutes were measured on the two phases with methanol-water mobile phases containing triethylamine at different concentrations and analyzed by use of linear solvation energy relationships (LSER). Variation of the resulting LSER coefficients—v (hydrophobicity),r (polarizability),s (dipolarity),b (hydrogen-bond (HB) donating acidity), anda (HB accepting strength)—were examined to see how TEA affects the intermolecular interaction properties of the mobile and stationary phases and hence the retention of the solutes. Addition of TEA to the mobile phase changes the interaction properties of both conventionally polymerized and horizontally polymerized ODS; the effect is greater for the conventional phase. The HB donating acidity (b) of conventional polymeric ODS is significantly reduced by addition of TEA. For the mobile phases studied the magnitudes of theb andv coefficients for the horizontally polymerized ODS phase are greater than for the conventional phase. The different interaction properties of the two polymeric phases arise mainly as a result of differential adsorption of TEA, because of the very different amounts of surface silanol groups present on the two phases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02466905
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  • 7
    Electronic Resource
    Electronic Resource
    Determination of myristicin in rat serum samples using microbore high performance liquid chromatography with column-switching (1998)
    Springer
    Chromatographia 48 (1998), S. 365-368 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Microbore columns ; Column-switching ; Myristicin ; Serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A microbore high-performance liquid chromatographic method with column-switching was developed for the analysis of myristicin from rat serum without prepurification. Deproteinization, fractionation, concentration and separation of analyte were carried out by appropriate switching of columns and using solvent mixtures. The method showed excellent precision, accuracy and speed with a detection limit of 10 ng mL−1 from 25 μL of serum. The total analysis time per sample was 25 min and the coefficients of variation for intra- and inter-assay were less than 1.8%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467705
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  • 8
    Electronic Resource
    Electronic Resource
    A review of recent observations concerning the synaptic organization of the basilar pontine nuclei (1988)
    New York, NY : Wiley-Blackwell
    Journal of Electron Microscopy Technique 10 (1988), S. 229-246 
    Details
    ISSN: 0741-0581
    Keywords: Cerebellum ; Cerebral cortex ; Dorsal column nuclei ; Cerebellar nuclei ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Natural Sciences in General
    Notes: Ultrastructural studies are described that have identified in the basilar pontine nuclei (BPN), the synaptic boutons formed by the corticopontine, cerebellopontine, tectopontine, and dorsal column nucleipontine afferent projection systems. In addition, immunocytochemical studies visualized neuronal somata, dendrites, and synaptic boutons that contain immunoreactivity for GABA or the synthesizing enzyme glutamic acid decarboxylase (GAD).Based upon differences in the mode of degeneration and postsynaptic locus of degenerative synaptic boutons in the BPN, it is suggested that two types of cortical neurons and three classes of deep cerebellar nuclear cells project to the BPN. For similar reasons, it appears that two types of neurons in the dorsal column nuclei project to the BPN while only one type of afferent synaptic bouton takes origin from the superior colliculus. Furthermore it appears that the population of BPN neurons projecting to the paramedian lobule receives convergent inputs from the cutaneous periphery and the corresponding region of sensorimotor cortex. Studies employing GAD immunohistochemistry indicate that GABA-ergic neurons and axon terminals are present in the BPN and thus support the suggestion that a local inhibitory interneuron is present within the BPN. Taken together these observations suggest that basilar pontine neurons might play a more active role in the integration of various types of information destined for the cerebellar cortex than has previously been recognized.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jemt.1060100303
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