Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Invasive meningioma: A tumour with high proliferating and “recurrence” potential (1995)
    Springer
    Acta neurochirurgica 136 (1995), S. 127-131 
    Details
    ISSN: 0942-0940
    Keywords: Argyrophilic nucleolar organizer regions (AgNORs) ; invasiveness ; meningioma ; proliferating cell nuclear antigen (PCNA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A study was undertaken to investigate the correlation between histological invasiveness and proliferating potential and clinical recurrence in meningioma. In 39 meningiomas, the histological findings at the tumour-brain interface zone were classified into 3 types, consisting of 29 cases of non-invasion (NON), 7 cases of nodular invasion (NOD), and 3 cases of intermingled invasion (INT). Proliferating cell nuclear antigen (PCNA) and argyrophilic nucleolar organizer region (AgNOR) indices were studied. PCNA indices (mean±standard error) of NON, NOD, and INT were 1.7±0.1%, 5.2±0.5%, and 7.5±0.7%, respectively, and the AgNOR indices (dot number/nucleus) were 1.50±0.03, 2.00±0.04, and 2.22±0.07, respectively. Significant differences were found among the three types in both parameters. Clinically, tumour recurrence was observed in 1/29 NON, 4/7 NOD, and 2/2 INT cases, indicating a higher incidence of recurrence in invasive meningiomas (NOD plus INT). Four of 32 patients who underwent gross total removal of the tumours showed recurrence, and all of these four tumours were invasive meningiomas. The results of the present study showed that tumour invasiveness as measured by PCNA + AgNOR indices correlated well with high proliferative potential and clinical recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Stereoselective disposition and chiral inversion of KE-298, a new antirheumatic drug, in rats (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 9 (1997), S. 22-28 
    Details
    ISSN: 0899-0042
    Keywords: pharmacokinetics ; metabolism ; stereoselectivity ; protein binding ; binding site ; displacement ; metabolic chiral inversion ; chiral HPLC ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The present study was an attempt to elucidate the relationship between stereoselective pharmacokinetics and protein binding of KE-298 and its active metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2). Metabolic chiral inversion was also investigated. The levels of unchanged KE-298 in plasma after oral administration of (+)-(S)-KE-298 to rats were lower than those of (-)-(R)-KE-298, whereas the levels of M-1 and M-2 after administration of (+)-(S)-KE-298 were higher than after (-)-(R)-KE-298. In vitro, rat plasma protein binding of (+)-(S)-KE-298 was lower than that of (-)-(R)-KE-298. In contrast, the binding of (+)-(S)-M-1 and (+)-(S)-M-2 was higher than that of (-)-(R)-M-1 and (-)-(R)-M-2. Displacement studies revealed that the (+)-(S) and (-)-(R)-enantiomers of KE-298 and their metabolites bound to the warfarin binding site on rat serum albumin. These results suggest that the stereoselective plasma levels in KE-298 and its metabolites were closely related to enantiomeric differences in protein binding, attributed to quantitative differences in binding to albumin rather than to the different binding sites. Unidirectional chiral inversion was detected after oral administration of either (-)-(R)-KE-298 or (-)-(R)-M-2 to rats both yielding (+)-(S)-M-2. Chirality 9:22-28, 1997 © 1997 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
  • 3
    Electronic Resource
    Electronic Resource
    Thermospray liquid chromatography/tandem mass spectrometry of thermally labile xenobiotic conjugates (1992)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 21 (1992), S. 285-291 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A strategy for thermospray liquid chromatography/tandem mass spectrometry (TSP LC/MS/MS) of very thermally labile xenobiotic conjugates, such as acetaminophen (AA) conjugates, selected as model compounds in biological fluid, was examined. The vaporizer temperature as well as collision energy were optimized using authentic AA-glutathione conjugate without modification of any analytical conditions, including mobile-phase composition, ion source temperature and repeller voltage. The [MH]+ ion intensities in the parent ion mass spectrum of m/z 182 from the conjugate at a collision energy of -25 eV were improved and maximized with a lowering of the vaporizer temperature from 115°C, corresponding to the optimal vaporization temperature of the mobile phase, to 80°C. Bile obtained from rats was treated with an equimolar mixture of AA and (2H3)AA was directly injected into the TSP LC/MS/MS system to perform the metabolic mapping of AA. The glucuronic acid, sulphuric acid, glutathione and cysteinylglycine conjugates of AA, in addition to the parent drug, were detectable by the parent ion scan mode, and confirmation of each structure could be obtained by the daughter ion scan mode. These conjugates appeared to show a marked temperature effect on the quality of TSP tandem mass spectra and sensitivity.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200210604
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...