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  • Annonaceae  (4)
  • Engineering  (3)
  • brine shrimp  (3)
  • rat  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats (1990)
    Springer
    Journal of neural transmission 80 (1990), S. 189-194 
    Details
    ISSN: 1435-1463
    Keywords: Nicotine enantiomers ; pain ; spinal analgesia ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spinalized rats received an intrathecal injection of either (−)-nicotine or (+)-nicotine in order to study the stereoselectivity of antinociception. Pain threshold was measured using the tail-flick test. Both stereoisomers had antinociceptive effects, but (−)-nicotine was up to 970 times more potent, depending on test conditions. The antinociceptive action of (−)-nicotine was antagonized by mecamylamine and yohimbine but not by naloxone and atropine. The findings show that spinal mechanisms are highly stereoselective toward nicotine, and suggest that primarily nicotinergic andalpha-adrenergic receptors are involved in its central antinociceptive effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245120
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of tranylcypromine enantiomers on monoamine uptake and release and imipramine binding (1986)
    Springer
    Journal of neural transmission 65 (1986), S. 135-145 
    Details
    ISSN: 1435-1463
    Keywords: Tranylcypromine enantiomers ; monoamine uptake ; monoamine release ; dopamine ; noradrenaline ; serotonin ; synaptosome ; imipramine binding ; blood platelet ; stereoselectivity ; rat ; rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies were carried outin vitro to determine effects of tranylcypromine enantiomers ([+]- and [−]-TCP) on uptake and release of 5-HT, DA and NA in rat synaptosomes and on imipramine binding to rabbit platelets. (+)-TCP was more potent than (−)-TCP as inhibitor of 5-HT uptake and imipramine binding, whereas (−)-TCP was more potent than (+)-TCP as inhibitor of DA and NA uptake. The enantiomers differed only slightly in their effects on monoamine release. The findings agree with previous reports on the stereoselectivity of monoaminergic mechanisms toward TCP enantiomers, and support the notion that the 5-HT uptake site may be associated with the imipramine binding site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01256489
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sylvaticin: A new cytotoxic and insecticidal acetogenin fromRollinia sylvatica (Annonaceae) (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 324-327 
    Details
    ISSN: 1420-9071
    Keywords: Sylvaticin ; acetogenin ; Rollinia sylvatica ; Annonaceae ; brine shrimp ; cytotoxicity ; insecticidal ; striped cucumber beetle ; European corn borer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Sylvaticin (I), a new tetrahydroxy annonaceous acetogenin with nonadjacent tetrahydrofuran rings, has been isolated from the dried fruits ofRollinia sylvatica St. Hil. (Annonaceae). This compound is extremely cytotoxic to human tumor cells and shows promising insect control properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951779
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Annonacin, a novel, biologically active polyketide fromAnnona densicoma (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 947-949 
    Details
    ISSN: 1420-9071
    Keywords: Annonacin ; polyketide ; Annona densicoma ; Annonaceae ; biological activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new linear polyketide, Annonacin (I), has been isolated from active extracts of the stembark ofAnnona densicoma Mart. Annonacin (I) is highly cytotoxic and is active in an assay designed to detect antimitotic agents. The structure of (I) was determined by analysis of spectroscopic data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951681
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  • 5
    Electronic Resource
    Electronic Resource
    Goniothalamicin and annonacin: Bioactive acetogenins fromGoniothalamus giganteus (Annonaceae) (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 83-85 
    Details
    ISSN: 1420-9071
    Keywords: Goniothalamicin ; annonacin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; insecticidal ; cytotoxic ; antileukemic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid γ-lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity ofII was confirmed, andII is now also found to be weakly active against 3PS murine leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960258
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  • 6
    Electronic Resource
    Electronic Resource
    Gigantecin: A novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, fromGoniothalamus giganteus (Annonaceae) (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 539-541 
    Details
    ISSN: 1420-9071
    Keywords: Gigantecin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; antimitotic ; cytotoxic ; crown gall tumors ; potato disc assay ; 9 ASK
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid γ-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954260
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of 3,N,N′-trimethyl-2-phenyl-1,4-piperazine diastereomers on monoamine uptake and monoamine oxidase in rat brain (1992)
    Springer
    Journal of neural transmission 88 (1992), S. 177-185 
    Details
    ISSN: 1435-1463
    Keywords: Phenylpiperazine ; monoamine uptake ; NA ; DA ; 5-HT ; MAO ; phenylethylamine ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The diastereomers of 3,N,N′-trimethyl-2-phenyl-1,4-piperazine dihydrochloride (TPP) were tested for their effects on NA, DA and 5-HT uptake in synaptosomes prepared from hypothalamus, corpus striatum, and frontal cortex, respectively. The diastereomers differed with respect to their inhibitory properties. (2R, 3R)-TPP was more potent than the other diastereomers on NA and DA uptake, whereas (2S, 3S)-TPP was least potent. In contrast, the (2S, 3S)- and (2 S, 3R)-diastereomers of TPP were more potent than (2R, 3R)- and (2R, 3S)-TPP as inhibitors of 5-HT uptake. None of the diastereomers affected monoamine oxidase activity. The findings show that the diastereomers of TPP interact stereoselectively with neuronal mechanisms for monoamine uptake, and that the (S)-configuration at the 2 carbon is important for inhibitory actions of TPP on 5-HT uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244731
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    The use of analytic surfaces for the design of centrifugal impellers by computer graphicsThis paper is Crown copyright and is reproduced with the permission of the Controller, Her Majesty's Stationery Office. (1973)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 7 (1973), S. 137-154 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper shows how analytic surfaces can be used to define the vanes of an impeller of a centrifugal compressor. The analysis has been given of a cubic-linear patch for representing three-dimensional geometries. An example has shown how this type of patch can be successfully used to model the geometry of centrifugal or mixed flow impellers having 'swept back vanes at the outlet.The analysis has been programmed for the Atlas computer at the Computer Aided Design Centre (CADC), Cambridge and set up in such a way that the designer can examine systematically a range of impeller shapes.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620070205
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Boundary integral analysis of transient thermoelasticity (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 13 (1989), S. 283-302 
    Details
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: A simple and efficient method for the solution of uncoupled transient thermoelastic problems using boundary integral techniques is presented. The method employs a Laplace transformation to remove temporarily the time dependence of the governing equations. Numerical analysis is then carried out in the transform space, and results in the time-position space are found by numerical inversion of the Laplace transform. The method has the advantage that it avoids time-stepping and the costly evaluation of domain integrals. Boundary element and analytic solutions are compared, and the effect of cooling on the stresses around a deep underground opening is examined.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nag.1610130305
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    BOUNDARY ELEMENT ANALYSIS OF LINEAR THERMOELASTIC CONSOLIDATION (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 20 (1996), S. 457-488 
    Details
    ISSN: 0363-9061
    Keywords: Linear thermo-poro-elastic materials ; boundary element method ; Green's functions ; Dirac delta functions ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: This paper presents a direct boundary element method of numerical analysis, formulated in the Laplace transform domain, for a plane strain analysis of a linear thermo-poro-elastic material consolidating in the presence of a heat source. The equations governing the behaviour of the material are assumed to be a set of self-adjoint and fully coupled linear equations. A physical intepretation of the constants appearing in the linear theory relevant to engineering applications is presented. A boundary integral equation is developed from the governing equations in a straightforward way using the properties of Dirac delta functions, and an approximate boundary element method of numerical analysis is implemented using the Green's functions derived previously by the authors. The numerical analysis presented is motivated by the engineering design of a heat generating radioactive waste repository located deep underground. For this reason, there is a description of the application of the boundary integral equation method presented to the numerical solution of several problems of theoretical and practical interest in the area of radioactive waste disposal in clay-like soils.
    Additional Material: 20 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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