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  • 1
    ISSN: 1434-0879
    Keywords: Prostatic carcinoma ; Plasma kinetics ; Testosterone ; Ethinyl oestradiol ; Anti-prolactin ; Bromocriptine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the light of the high incidence of cardiovascular side effects with oestrogen therapy in patients with prostatic cancer, other medications altering androgen metabolism are under investigation. The influence of the anti-prolactin bromocriptine (CB154) on plasma kinetics of testosterone and on endogenous hormones was studied and compared with the effect of ethinyl oestradiol in 25 patients with prostatic carcinoma. Bromocriptine significantly suppressed both prolactin and testosterone, inhibited the transfer of androgen from the inner pool into the deep compartment and favoured its degradation. Ethinyl oestradiol decreased testosterone, LH and FSH, and prolonged the biological half-life of testosterone. The effects of bromocriptine on androgen metabolism might be of therapeutic value in patients with prostatic carcinoma.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 103 (1968), S. 277-284 
    ISSN: 1432-1076
    Keywords: Meningokokkenmeningitis ; Meningokokkensepsis ; Defektzustände
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden 200 Kinder im Alter von 2–171/2 Jahren nach einer in den Jahren 1955–1966 abgelaufenen Meningokokkenmeningitis und-sepsis eingehend nachuntersucht. Die Probanden wurden einer ausführlichen klinisch-neurologischen Untersuchung, einer Elektrencephalographie, Echoencephalographie und einem Kramer-Intelligenztest unterzogen. Dabei fanden sich bei 39,5% restlose Heilungen, bei 35% leichte und bei 19,5% schwerere Restschäden. Mit zunehmendem Alter der Kinder verringerten sich die schweren Spätschäden. Die restlichen 6% ließen nicht ausschließen, daß der zentral-nervöse Schaden nicht schon vor der Meningitis bestand bzw. nur eine Verschlimmerung durch die Erkrankung erfuhr. Da es sich um Nachuntersuchungen bei Überlebenden aus zum Teil entfernten Gegenden handelt, liegen keine Zahlen über die Letalität in dieser Zeit vor.
    Notes: Summary 200 children of 2 to 171/2 years of age who have had a meningococcal meningitis or -sepsis in 1955–1966 have been reexamined. The patients were submitted to an extensive neurological examination with electroencephalography and echoencephalography and a Kramer-intelligencetest. 39,5% of the patients were found to be completely cured, 35% had mild, 19,5% had severe residual damage. With increasing age of the children the severe damage lessened. In 6% of the patients a preexistent cerebral damage which was aggravated by the meningitis could not be ruled out. Letality numbers during this time could not be established as the surviving patients came out of distant areas.
    Type of Medium: Electronic Resource
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