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  • 1
    Electronic Resource
    Electronic Resource
    Alterations of peripheral testosterone metabolism after induced hypoprolactinemia in patients with prostatic carcinoma (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 49-51 
    Details
    ISSN: 1432-1440
    Keywords: Bromocriptin ; Prostatakarzinom ; Prolaktin ; Androgene ; Testosteron ; Bromocriptine ; Prostatic Carcinoma ; Prolactin ; Androgens ; Testosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 12 patients with advanced prostatic carcinoma the effect of bromocriptine-induced hypoprolactinemia on the peripheral androgen metabolism was investigated after3H-testosterone injection under conditions that each individual served as his own control. After a 5-day significant prolactin suppression, the elimination of3H-label 1 h after testosterone injection was about 45% and equal to pre-bromocriptine values. The recovery of dihydrotestosterone separated by silica gel T.L.C., however, was significantly augmented, resulting in a marked decrease of the testosterone/dihydrotestosterone ratio from 12.2 to 6.3. This induced 5α-reductase activity after prolactin suppression is in accordance with our earlier findings on prostatic carcinoma tissue, matches well with observations of Magrini et al. on induced hyperprolactinemia and may be a new approach to the understanding of androgen dependent disorders.
    Notes: Zusammenfassung Beeinflussung des peripheren Testosteronstoffwechsels durch induzierte Hypoprolaktinämie bei Patienten mit Prostatakarzinom. Der Effekt einer Bromocriptin-induzierten Hypoprolaktinämie auf den peripheren Androgenstoffwechsel wurde bei 12 Patienten mit fortgeschrittenem Prostatakarzinom nach Injektion von3H-Testosteron in der Weise untersucht, daß jeder Patient als seine eigene Kontrolle galt. Nach einer fünftägigen Hypoprolaktinämie betrug die Elimination androgengebundener Radioaktivität 1 Stunde nach Testosteroninjektion 45% und entsprach dem Wert vor Bromocriptinbehandlung. Die durch Silica Gel-Dünnschichtchromatographie analysierte Recovery von Dihydrotestosteron war allerdings signifikant erhöht. Daraus ergab sich eine deutliche Verminderung des Verhältnisses Testosteron/Dihydrotestosteron von 12.2 auf 6.3. Diese induzierte Kapazität der 5α-Reduktase nach peripherer Prolaktin-Suppression steht in Übereinstimmung mit unseren früheren Ergebnissen an Prostatakarzinomgewebe, wird unterstützt durch Beobachtungen von Magrini et al. bei induzierter Hyperprolaktinämie und könnte wichtige Rückschlüsse für das Verständnis androgenabhängiger Krankheitsbilder liefern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476982
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  • 2
    Electronic Resource
    Electronic Resource
    Active immunotherapy of stage IV renal cell cancer using autologous tumor cells (1986)
    Springer
    World journal of urology 3 (1986), S. 245-248 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 53 patients with stage IV renal cell carcinoma were treated by vaccination with autologous tumor cells in Candida-antigen after palliative tumor nephrectomy. Follow-up has been up to 9 years. Complete remission within 48 months after nephrectomy was observed in 3 patients, while 6 showed partial remission and 18 are stable with disease. Of 26 patients with rapid progression, 17 died within 1 year after operation. The best response was seen in metastases to the liver and lung. CNS-lesions or bone metastases do not appear to respond to this treatment. We conclude that this mode of therapy is beneficiary to a certain group of patients and should be offered, as no severe side effects have been observed so far. Whether new perspectives of adoptive immunotherapy using tumor-specific monoclonal antibodies or recombinant interferons will prove effective remains to be seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00632186
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  • 3
    Electronic Resource
    Electronic Resource
    Extracorporeal shock wave lithotripsy (ESWL): alternatives and adjuvant procedures (1985)
    Springer
    World journal of urology 3 (1985), S. 48-52 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Within a short time, extensive statistics on ESWL have documented its efficiency in the treatment of most renal and ureteral stones. Approximately 20% of all stone patients, however, require additional or other forms of therapy, such as URS, PNL, or surgery. Up to now, the differential indications for these procedures have not been completely established. A crucial factor for successful application of ESWL is stone volume and localization. Large stones with a central stone mass may be successfully treated by combining ESWL and PNL, while surgery is still preferred in those with a peripheral stone mass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326888
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  • 4
    Electronic Resource
    Electronic Resource
    Follow-up results of embolization therapy for palliation of incurable bladder carcinoma (1985)
    Springer
    World journal of urology 3 (1985), S. 134-138 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Embolization therapy of the renal artery (N=10), hypogastric arteries (N=18) and ureter (N=24) was performed in 41 patients with incurable bladder carcinoma for palliation of gross hematuria and severe dysuria. Careful follow-up of the patients until death gave a mean survival time of 12.3 months after embolization; 6 patients are still alive. The results show that embolization therapy is justified for management of bleeding and dysuric complaints. Ureteral occlusion alone has almost no effect on hematuria. Combined embolization procedures yield better results than occlusion of the vessels or the ureter. Ureteral occlusion with a detachable balloon is superior to embolization with tissue adhesive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326723
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  • 5
    Electronic Resource
    Electronic Resource
    Experience with palliative percutaneous nephrostomy in bladder cancer patients (1985)
    Springer
    World journal of urology 3 (1985), S. 131-133 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Minimal percutaneous nephrostomy as a palliative urinary diversion was performed in 50 patients with advanced bladder cancer disease. The average survival time was 6.6 months, with 38% of the patients alive after 6 months. Although 88% of the patients died within one year, 2 (5%) are still alive after more than 2 years. Each case of palliative diversion is an individual one, with many different factors influencing the decision. Prolonging life cannot be an indication for diversion. Percutaneous nephrostomy in combination with other percutaneous techniques provides the urologist with excellent therapeutic tools to avoid surgery in such emergency situations as uremia or local tumor symptoms. This may offer these patients more peace in their last days of life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326722
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  • 6
    Electronic Resource
    Electronic Resource
    The mainz-pouch (mixed augmentation ileum 'n zecum) for bladder augmentation and continent diversion (1985)
    Springer
    World journal of urology 3 (1985), S. 179-184 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ideal urinary reservoir constructed from bowel material should be a low-pressure system with a high capacity, capable of preventing upper tract deterioration resulting from ureteral obstruction or reflux. It should achieve reliable control of continence and assure easy emptying of the reservoir. In the Mainz-pouch, the combination of cecum and ileum, the latter of which is able to absorb pressure waves created by the cecum, produces a low-pressure system with a high capacity immediately postoperatively. By incorporating large bowel in our pouch, ureteral implantation can be done using a simple and reliable standard antireflux technique with a submucosal tunnel. The Mainz-pouch has been done since 1983 in 26 patients. Of these 11 were for bladder augmentation after subtotal cystectomy and 15 for continent urinary diversion. All of the patients with bladder augmentation are completely dry day and night; 2 patients with myelomeningocele are on intermittent catheterization for bladder evacuation. The remainder void spontaneously without significant residual urine. Of 15 patients with Mainz-pouch urinary diversion, 4 had an alloplastic stomal prosthesis implanted for control of continence and 11 have isoperistaltic ileo-ileal invagination, where by the invagination valve can easily be fixed to the intussuscepting ileum by sutures or staples. Of the 4 alloplastic stomal prostheses, 2 have been removed because of infection. In 1 of these patients, an ileo-ileal invagination was performed in the same operation to achieve continent closure. All patients with the invagination valve, as well as the 2 patients with an alloplastic stomal prosthesis, are completely continent, but in 3 cases, revision of the ileo-ileal invagination became necessary due to prolapse of the valve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326990
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  • 7
    Electronic Resource
    Electronic Resource
    Gonadotropin-releasing hormone analogues for palliation of carcinoma of the prostate (1983)
    Springer
    World journal of urology 1 (1983), S. 40-48 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since the introduction of contrasexual treatment as the basic concept of palliation of prostatic carcinoma in the 1940's, orchiectomy, estrogens, and, in recent years, antiandrogens have become generally accepted treatment forms. Three facts: 1) estrogen treatment being at best palliative and at worst dangerous; 2) surgical castration having psychological impacts, at least in the younger age group; and 3) both being probably ineffective from the beginning, have led us to investigate an alternative of minimal toxicity and possible reversibility in the initial treatment of advanced prostatic carcinoma. 12 patients with far advanced carcinoma of the prostate were treated with the gonadotropin releasing hormone analogue [D-Ser(But)6]-LH-RH(1-9)-nonapeptide ethylamide (Buserelin, Hoe 766), which caused down-regulation of pituitary luteinizing hormone (LH) receptors and suppressed testosterone to castrate levels within four weeks. The production rate of testosterone (PR-T) was lowered to values comparable to those after bilateral orchiectomy within two weeks. Subjectively, patients responded favorably with a relief of metastatic bone pain in all cases and an improvement of the Karnofsky Performance Index to an average score of 75 in those patients who had had an initially low index averaging 45. Objective responses included reduction of local tumor mass with resolution of bilateral ureteral obstruction, regression of pulmonary and bone metastases, and decrease of initially elevated serum acid phosphatase concentration. On the basis of these preliminary data, it should be expected that treatment of far advanced prostatic adenocarcinoma with gonadotropin-releasing hormone analogues is a safe, nontoxic and effective form of palliation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326861
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  • 8
    Electronic Resource
    Electronic Resource
    Histophotometry: A new method for automated histological examination of solid tissue samples demonstrated on bladder cancer (1979)
    Springer
    Urological research 7 (1979), S. 113-118 
    Details
    ISSN: 1434-0879
    Keywords: Bladder túmours ; Histophotometry ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to demonstrate the ability of a new method to discriminate between benign and malignant tissue. Tissue samples from three patients with bladder tumours and one patient with bladder diverticula have been examined by histophotometry. This method, based on the correlation of nuclear volume and nucleic acid contents per cell uses thick formalin fixed samples. The results are obtained by measurements averaging more than one hundred thousand cells per sample. By this histophotometric examination a clear differentiation between malignant and benign tissue could be achieved. It was also possible to determine the degree of malignancy and to differentiate between infiltrating and noninfiltrating tumour, as well as inflamed bladder tissue. The results obtained histophotometrically were compared with the histological findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254691
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  • 9
    Electronic Resource
    Electronic Resource
    Testosterone metabolism in patients with advanced carcinoma of the prostate: A comparative in vivo study of the effect of oestrogen and anti-prolactin (1978)
    Springer
    Urological research 6 (1978), S. 159-165 
    Details
    ISSN: 1434-0879
    Keywords: Prostatic carcinoma ; Plasma kinetics ; Testosterone ; Ethinyl oestradiol ; Anti-prolactin ; Bromocriptine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the light of the high incidence of cardiovascular side effects with oestrogen therapy in patients with prostatic cancer, other medications altering androgen metabolism are under investigation. The influence of the anti-prolactin bromocriptine (CB154) on plasma kinetics of testosterone and on endogenous hormones was studied and compared with the effect of ethinyl oestradiol in 25 patients with prostatic carcinoma. Bromocriptine significantly suppressed both prolactin and testosterone, inhibited the transfer of androgen from the inner pool into the deep compartment and favoured its degradation. Ethinyl oestradiol decreased testosterone, LH and FSH, and prolonged the biological half-life of testosterone. The effects of bromocriptine on androgen metabolism might be of therapeutic value in patients with prostatic carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261317
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