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  • 1
    Electronic Resource
    Electronic Resource
    Senile dementia of Alzheimer type characterized by laminar neuronal loss exclusively in the hippocampus, parahippocampus and medial occipitotemporal cortex (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 575-580 
    Details
    ISSN: 1432-0533
    Keywords: Senile dementia of Alzheimer's type ; Alzheimer's disease ; Pick's disease ; Laminar neuronal loss ; Limbic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven cases of senile dementia of Alzheimer type (SDAT) with unusual clinico-pathological findings are reported. The patients showed neuronal loss in laminar pattern, with gliosis exclusively confined to the CA1 of the hippocampus, the area of the hippocampal gyrus (entorhinal cortex) and medial occipitotemporal cortex. This change was more pronounced in the oral region. The subcortical white matter showed more pronounced fibrillary gliosis than loss of myelin. Both Alzheimer's neurofibrillary tangles and senile plaques were less marked than those usually seen in SDAT. The mental disturbance started after the age of 65 in all patients. The main clinical feature was marked character change in addition to disturbance of cognitive function. Cranial computed tomography showed marked dilatation of the oral portion of the inferior horn of the lateral ventricle in the early stage. It was apparent that although the cases in this group could be incorporated within in the spectrum of SDAT, they could also be considered to represent a variant of SDAT. This group could contribute to an understanding of the clinico-pathological spectrum of SDAT as well as indicating ways of managing such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307623
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Curly fibers are tau-positive strands in the pre- and post-synaptic neurites, consisting of paired helical filaments: observations by the freeze-etch and replica method (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 111-115 
    Details
    ISSN: 1432-0533
    Keywords: Curly fibers ; Anti-tau antibody ; Immunoelectron microscopy ; Rapid-freeze and deep-etch method ; Neuritic paired helical filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of the curly fibers was examined by the transmission and immunoelectron microscopy as well as by the rapid-freeze, deep-etch and replica method. The curly fibers consisted mainly of paired helical filaments (PHF) in the neuropils, both pre- and post-synaptic. On the deep-etch replicas, PHF in the neurites had similar dimensions to those of Alzheimer's neurofibrillary tangles in the nerve cell somata, having the width of 28 to 36 nm. The two component filaments, 14 to 18 nm in width, were twisted left-handedly with about 70- to 90-nm intervals. There were also cross-bridging fibrils of about 6 nm in diameter connecting the neighboring PHF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334498
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of polymer composition on the production of cationic multihollow polymer particles by the stepwise acid/alkali method (1999)
    Springer
    Colloid & polymer science 277 (1999), S. 589-594 
    Details
    ISSN: 1435-1536
    Keywords: Key words Hollow ; Particle ; Emulsion polymerization ; Morphology ; Swelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The effect of the polymer composition on the formation of multihollow structures formed within submicron-sized styrene–butyl acrylate–dimethylaminoethyl methacrylate terpolymer particles by the “acid/alkali method” proposed by the authors was examined. The cationic particles were produced by seeded emulsion terpolymerization with 2,2′-azobis(2-amidinopropane) hydrochloride initiator. The dimethylaminoethyl methacrylate content and the glass-transition temperature of the terpolymer greatly affected the formation of the multihollow structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050430
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of nonionic emulsifier on the production of multihollow polymer particles by the stepwise acid/alkali method (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 358-363 
    Details
    ISSN: 1435-1536
    Keywords: Key words Hollow ; Particle ; Emulsion polymerization ; Morphology ; Swelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The effects of nonionic emulsifier on the formation of multihollow structures formed within sub-micron-sized polymer particles by the “acid/alkali method” proposed by the authors were examined. The original acid-swellable particles were produced by seeded emulsion terpolymerization of styrene, butyl acrylate, and dimethylaminoethyl methacrylate. The results indicate that the nonionic emulsifier had a great effect on the formation of multihollow particles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050525
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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