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  • 1
    Electronic Resource
    Electronic Resource
    DNA content of neurons in rat central nervous system
    Amsterdam : Elsevier
    Experimental Cell Research 60 (1970), S. 454-456 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(70)90541-0
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  • 2
    Electronic Resource
    Electronic Resource
    Nisoldipine (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 1 (1983), S. 0 
    Details
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3466.1983.tb00450.x
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  • 3
    Electronic Resource
    Electronic Resource
    Mikrospektrophotometrische Untersuchungen am Hämosiderin (1966)
    Springer
    Virchows Archiv 340 (1966), S. 352-359 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The physical-optical properties of hemosiderin or siderin were investigated microspectrophotometrically. Based on the absorption spectrum of erythrocytes and of Fe(OH)3 solutions, the absorption maxima occuring in experimentally induced siderin and hemosiderin (by injecting the iron solution and by implantation of blood) could be defined, as well as in human siderin: 1. The absorption at 280 mμ is due to the organic protein carrier-substance containing tyrosin and tryptophane. 2. The iron component in the siderin causes an absorption at 330–360 mμ. The position of the maximum of the absorption depends on different factors. 3. The soret band (around 410 mμ) could not be demonstrated constantly: with increasing age of the experimentally induced siderin and hemosiderin, the absorption disappears at 410 mμ. 4. Human siderin shows in the same properties of absorption, yet the component haem may be missing.
    Notes: Zusammenfassung In mikrospektrophotometrischen Untersuchungen wurden die physikalischoptischen Eigenschaften des Hämosiderins bzw. Siderins untersucht. Ausgehend vom Absorptionsspektrum von Erythrocyten und Lösungen von Fe(OH)3 konnten die auftretenden Absorptionsspektren im experimentell erzeugten Siderin (Injektion von Eisenlösung) und Hämosiderin (Blutimplantation) sowie menschlichem Siderin geklärt werden: 1. Die Absorption bei 280 mμ ist auf die proteinhaltige organische Trägersubstanz mit tyrosin- und tryptophanhaltigen Eiweißkörpern zurückzuführen. 2. Die Eisenkomponente im Siderin bedingt eine Absorption bei 330–360 mμ, wobei die Lage des Absorptionsmaximums von verschiedenen Faktoren abhängig ist. 3. Die Soretbande (um 410 mμ) war nicht konstant nachweisbar. Mit zunehmendem Alter von experimentell erzeugtem Siderin und Hämosiderin verschwindet die Absorption bei 410 mμ. 4. Menschliches Siderin weist gleiche Absorptionseigenschaften auf, wobei die Hämkomponente fehlen kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02438767
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  • 4
    Electronic Resource
    Electronic Resource
    Time-response-relationship of embryotoxic effects of lithium carmine in mice (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 270 (1971), S. 316-318 
    Details
    ISSN: 1432-1912
    Keywords: Carmine ; Embryotoxic Effects ; Time of Administration ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997031
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  • 5
    Electronic Resource
    Electronic Resource
    Embryotoxische Wirkungen von Trypanblau bei Mäusen in Abhängigkeit vom Behandlungszeitpunkt (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 20-30 
    Details
    ISSN: 1432-1912
    Keywords: Embryotoxic Actions ; Trypan Blue ; Time Factor ; Trypanblau ; Embryotoxicität ; Behandlungszeitpunkt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The embryotoxic effect of a single dose of trypan blue given to pregnant mice (NMRI/Han-strain) on different days of pregnancy was studied. Seven groups each comprising 10–27 animals were subcutaneously injected with 1% trypan blue solution in a dose of 100 mg/kg body weight. The injection was performed on the 6th, 7th, 8th, 9th, 10th, 11th or 14th day of gestation. 40 animals, forming a control group received a single injection of saline over the same period. The findings were as follows: 1. A statistically higher rate of malformations in comparison to the control group is found to occur when the injection of trypan blue is made between the 6th and 10th day of pregnancy. Within this period the strongest teratogenic activity is observed when the trypan blue is administered on the 8th day of gestation. 2. The rate of resorptions in trypan blue treated animals over the period of pregnancy examined shows a significant increase over that of the control group. Here again the maximum is reached when the trypan blue has been injected on the 8th day. The effect of earlier and later injections is noticeably less. 3. The rate of retardation is increased by injections of trypan blue from the 8th day of gestation onward and by the 14th day the maximum has still not been attained. The morphology of the observed resorptions as well as that of the retarded and malformed fetuses is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997111
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  • 6
    Electronic Resource
    Electronic Resource
    Embryotoxische Dosis-Wirkungs-Beziehungen von Trypanblau bei Mäusen (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 31-40 
    Details
    ISSN: 1432-1912
    Keywords: Embryotoxic Actions ; Trypan Blue ; Dose Response ; Trypanblau ; Embryotoxicität ; Dosis-Wirkungs-Beziehungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The embryotoxic effect of trypan blue on pregnant mice of the NMRI-strain was studied in relation to the dose injected. In addition, the acute toxicity of trypan blue in the adult mouse was determined and compared with the fetal toxicity. The findings were as follows: 1. The acute toxicity of trypan blue given in 1% solution, was determined. The LD50 adult=267 mg/kg when the injection is made subcutaneously. 2. In all treated animals, whatever the size of the injected dose-25 mg/kg, 50 mg/kg, 100 mg/kg or 200 mg/kg-a significant increase is observed both in the overall embryotoxic activity and in the resorption-, malformation- and retardationrates, compared to non-treated animals. Malformation- and retardation-rates as well as the overall embryotoxic activity are found to increase in parallel with increasing dose without a maximum having been attained at 200 mg/kg. In contrast, the rate of resorptions appears to be independent of the dose. 3. The dose that allows 50% of all implantations to evolve into fetuses, showing no recognizable damage-is in the region of 67 mg/kg. This amounts to approximately 1/4 of the LD50 adult
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997112
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  • 7
    Electronic Resource
    Electronic Resource
    Zur Wirkung von Lithiumcarmin und Lithiumcarbonat auf die Embryonalentwicklung der Maus (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 270 (1971), S. 56-64 
    Details
    ISSN: 1432-1912
    Keywords: Carmine ; Lithium ; Embryotoxic Actions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Carmine in a 1% lithium carbonate solution, forms the acid vital dye lithium carmine. The present paper deals with the question whether the embryotoxic and teratogenic effects resulting from the administration of lithium carmine to mice are due to the carmine itself or to the lithium ions. Mice of the NMRI/Han strain were injected i. p. on the 8th day of pregnancy with 100 mg/kg carmine using either a 2.5% or a 4.0% lithium carmine solution. A third group of mice received 40 mg/kg lithium carbonate in 1% solution, corresponding to the dose of lithium given by injecting the 2.5% solution of lithium carmine. Control animals were injected with 0.2 ml of saline. The following results were obtained: 1. A dose of 100 mg/kg carmine, injected as a 2.5 or a 4.0% of lithium carmine solution, is embryotoxic and teratogenic. With both solutions the number of resorbed, malformed and retarded fetuses is nearly the same. 2. Injection of lithium carbonate significantly raises the number of resorptions, but only 1 out of 79 fetuses was malformed. The rate of retardations does not exceed that of the controls. 3. The malformations, which are described in some detail, are localized in the brain (exencephalies) and skeletal system (malformations of ribs and vertebral column).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997299
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  • 8
    Electronic Resource
    Electronic Resource
    Urinary antigens as markers of papillary toxicity. I Identification and characterization of rat kidney papillary antigens with monoclonal antibodies (1996)
    Springer
    Archives of toxicology 71 (1996), S. 80-92 
    Details
    ISSN: 1432-0738
    Keywords: Key words Rat papillary antigens ; Monoclonal antibodies ; Nephrotoxicity ; Papillary toxicity ; Urinary markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monoclonal antibodies were prepared in an attempt to develop diagnostic tools for the identification of toxic damage to the rat renal papilla. One IgG and five IgM monoclonal antibodies, reacting with antigens localized in the papilla were obtained. Three of the IgM class and the IgG class monoclonal antibodies were found to be specific for antigens localized in collecting ducts, two of them staining papillary collecting ducts more intensely than cortical collecting ducts. The IgG class antibody, termed Pap X 5C10, recognizes an antigen located at high density on the luminal side of papillary collecting duct epithelial cells and at lower density in cortical collecting duct cells. One of the IgM class monoclonal antibodies reacts with an antigen localized in epithelial cells of ascending and descending loops of Henle and of connecting tubules. Another of the IgM class monoclonal antibodies reacts with an antigen localized in the interstices of the inner medulla. All these monoclonal antibodies react with their antigens in native frozen as well as in Bouin-fixed and paraffin-embedded tissue slices. Molecular properties of the Pap X 5C10 antigen have been investigated by gel permeation chromatography, SDS-PAGE, Western blotting, and isoelectric focusing. The results indicate that the antigen in both its tissue-derived and urinary form is of large (150–200 kDa) molecular size and can be separated into two molecular species with isoelectric points of pH 7.2 and 7.3 respectively. In the urine the antigens recognized by the monoclonal antibodies form large complexes with Tamm-Horsfall protein. The antigen-containing complexes can be extracted from urine by adsorption to diatomaceous earth and elution with SDS-containing buffer. Using sandwich ELISA-type assays it is possible to determine the concentration of the antigens. In preliminary experiments we were able to show that at least three of the antigens are detected in the urine following toxic insults to the kidney. The monoclonal antibodies prepared and the tests developed thus may provide direct diagnostic access to the renal papilla and allow, for the first time, early detection of papillary damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050361
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructural observations on cell necrosis during formation of the neural tube in mouse embryos (1973)
    Springer
    Anatomy and embryology 141 (1973), S. 251-264 
    Details
    ISSN: 1432-0568
    Keywords: Closure of neural tube ; Cell necrosis ; Normal mouse embryos ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spontaneous cell death in the developing brain of 8.5–9 day old mouse embryos has been investigated with the electron microscope. Before closure of the neural tube, areas of cell death are found at the neuro-somatic junction. After closure of the neural tube degenerating cells are found in the dorsal midline of the prospective diencephalon. Ultrastructurally, cell degeneration is marked by chromatin condensation, increase in electron density of the structures in the cytoplasm and, in later stages, by a marked pycnosis of the dying cell. After fragmentation, the necrotic material as well as entire pycnotic cells are phagocytized and digested by cells of the neuroepithelium. An invasion of macrophages has not been observed. The significance of cell necrosis is discussed in relation to the normal formation of the neural tube and to the occurrence of certain induced malformations (exencephalies).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00519046
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  • 10
    Electronic Resource
    Electronic Resource
    Über die Gefäßversorgung des Corpus callosum der Katze (1969)
    Springer
    Anatomy and embryology 128 (1969), S. 28-39 
    Details
    ISSN: 1432-0568
    Keywords: Arterial supply ; Corpus callosum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 27 Katzen beiderlei Geschlechts wurde die Blutversorgung des Corpus callosum untersucht. Dabei wurden folgende Befunde erhoben: Der Balken der Katze wird im Bereich des Rostrum und Genu sowie im vorderen und mittleren Truncuabschnitt aus der Arteria cerebri anterior versorgt und zwar über Äste, die den Arteriae pericallosae und den Arteriae genu corporis callosi entstammen. Diese Äste wurden als Arteriae callosi superiores und inferiores bezeichnet. Lediglich im hinteren Truncusabschnitt und im Splenium erfolgt die Versorgung neben Ästen der A. pericall. auch über solche der Arteriae cerebri mediae und posteriores. Die Blutgefäße treten dolchartig in den Balken ein, teilen sich dann baumartig weiter auf und gehen in ein Capillarnetz über, das in Richtung des Nervenfaserverlaufes ausgezogen ist. Auf in der Literatur bereits bekannte, aber oft vernachlässigte Besonderheiten der Arteria carotis interna und des Circulus arteriosus wird hingewiesen.
    Notes: Summary In investigations on 27 cats of both sexes, the arterial supply of the corpus callosum was studied. The findings are as follows: In the region comprising rostrum and genu as well as in the fore and middle trunk sections, blood supplied by branches of the arteriae pericallosae and the arteriae genu corporis callosi which originate from the arteria cerebri anterior. These branches were designated arteriae callosi superiores and inferiores. However, in the posterior section of the trunk and in the splenium the blood is supplied by branches of the aa. pericall. and, in addition, by branches of the arteriae cerebri media and posteriores. The blood vessels penetrate the corpus callosum in bayonet fashion, then arborise and finally become a capillary network which is elongated in the direction of the course of the nerve fibres. Attention is drawn to peculiarities of the arteria carotis interna and the circle of Willis which, although known in the literature, are rarely referred to.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00522492
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