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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 61 (1983), S. 300-304 
    ISSN: 1432-0533
    Keywords: Cerebral lesions ; Experimental kuru ; Macaca nemestrina ; Asymmetry ; Focal inoculation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In Macaca nemestrina inoculated intracerebrally by a pin-point injection with a strain of kuru Kupenota (2nd passage), the lesions consisted of spongiosis of neuropile with severe astrocytic hyperplasia, located in the grey matter of cerebral hemispheres (cortex, neostriatum). In all cases, the distribution of lesions was asymmetrical, predominating on the side of injection. These results suggest that kuru agent could be replicate around the injection site, but the influence of the host and/or the strain could not be excluded.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 62 (1983), S. 31-40 
    ISSN: 1432-0533
    Keywords: Human pinealomas ; Ultrastructure ; Specific markers ; Pinealocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ultrastructural study of four pinealomas was carried out to precise eventual specific markers. Dark and clear cells joined with zonulae adherents, extensive and pleiomorphous processes, a complex vacuolar system, and characteristic organelles (lysosome-like structures, clear and dense-core vesicles, vesicle-crowned rodlets and related structures, microtubular sheaves and centriolar derivatives, membranous whorls, fibrous bodies, microtubules, heterogeneous cytoplasmic inclusions) offered a typical pattern. No correlation could be made between the histological and ultrastructural features. The authors stress the ultrastructural similarities between the human tumor cells and the mammalian pineal cells. Pinealomas appeared as a morphological entity distinct from neuronal and astrocytic tumors.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 65 (1984), S. 163-165 
    ISSN: 1432-0533
    Keywords: Human pinealomas ; Ultrastructure ; Paired twisted filaments ; Paired helical filaments ; Cytoskeleton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Paired twisted filaments (PTF) forming helices are described in tumor cells of three human pine-alomas. Each filament was 8.11±1.55 nm wide. The maximal width of the helix was 16.62±2.62 nm. The periodicity of the constrictions was 26.63±4.49 nm. These characteristics appeared original, suggesting protein, filaments possibly specific of pinealocytes. The similarities and discrepancies between PTF and Alzheimer's paired helical filaments (PHF) are discussed.
    Type of Medium: Electronic Resource
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