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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 477-478 
    ISSN: 1432-1440
    Keywords: Autonomous thyroid nodules ; Oral TRH test ; Results ; Autonomes Adenom ; Oraler TRH-Test ; Ergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 17 Patienten mit kompensierten autonomen Adenomen der Schilddrüse wurden TRH-Teste mit 200 µg i.v. und 40 mg oral durchgeführt. Bei 9 Patienten war TSH 30 min nach TRH i.v. normal (〉2.7 µU/ml), dagegen zeigten 8 Patienten einen subnormalen (〈2.7 µU/ml) oder fehlenden TSH-Anstieg. Nach verlängerter Stimulation mit 40 mg TRH oral war TSH 120–180 min bei 15 Patienten im Normbereich (〉2.7 µU/ml) und nur bei 2 Patienten subnormal (〈2.7 µU/ml). Bei 20 Patienten mit dekompensierten autonomen Adenomen der Schilddrüse lag TSH sowohl nach i.v. als auch nach oraler TRH-Stimulation in allen Fällen unter der Nachweisgrenze (〈0.8 µU/ml). Die Befunde sprechen dafür, daß der orale TRH-Test geeigneter ist als der i.v. TRH-Test, um zwischen kompensierten und dekompensierten autonomen Adenomen der Schilddrüse zu unter-scheiden.
    Notes: Summary In 17 patients with compensated autonomous adenomas of the thyroid, iv thyrotropin releasing hormone (TRH) tests (200 µg) and oral TRH tests (40 mg) were performed. In nine of these patients, thyroid-stimulating hormone (TSH) 30 min after iv TRH showed a normal (〉2.7 µU/ml) and in eight patients a subnormal (〈2.7 µU/ml) or negative response. However, after prolonged oral stimulation with 40 mg TRH, after 120–180 min TSH was normal (〉2.7 µU/ml) in 15 and subnormal (〈2.7 µU/ml) in two patients. In 20 patients with decompensated autonomous thyroid nodules, TSH was not detectable (〈0.8 µU/ml) after iv or oral TRH stimulation. Therefore, the oral TRH stimulation test seemed to be superior to the iv TRH test in the discrimination of compensated and decompensated autonomous adenomas of the thyroid.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-7089
    Keywords: Key words: Dual-head gamma camera ; Positron emission tomography ; Attenuation correction ; Oncological patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to evaluate a dual head coincidence gamma camera (DH-PET) equipped with single-photon transmission for 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (FDG) imaging in oncological patients. Forty-five patients with known or suspected malignancies, scheduled for a positron emission tomography (PET) scan, were first studied with a dedicated ring PET and subsequently with DH-PET. All patients underwent measured attenuation correction using germanium-68 rod sources for ring PET and caesium-137 sources for DH-PET. Ring PET emission scan was started 64±17 min after intravenous administration of 235±42 MBq FDG. DH-PET emission followed 160±32 min after i.v. FDG. Attenuation-corrected and non-attenuation-corrected images were reconstructed for ring PET and DH-PET. The image sets were evaluated independently by three observers blinded to clinical data and to results of conventional imaging. Attenuation-corrected ring PET as the standard of reference depicted 118 lesions, non-attenuation-corrected ring PET 113 (96%) lesions, and attenuation-corrected DH-PET and non-attenuation-corrected DH-PET, 101 (86%) and 84 (71%) lesions, respectively (P〈0.05). The lesion detection rate of attenuation-corrected and non-attenuation-corrected DH-PET was almost similar for lesions 〉20 mm, whereas attenuation correction increased the detection rate from 60% to 80% for lesions ≤20 mm (P〈0.01). A patient-based analysis revealed concordant results relative to attenuation-corrected ring PET for non-attenuation-corrected ring PET, attenuation-corrected DH-PET and non-attenuation-corrected DH-PET in 42 (93%), 36 (80%) and 31 (69%) patients, respectively. Differences might have influenced patient management in two (4%), six (13%) and ten (22%) patients, respectively. In conclusion, measured attenuation correction markedly improves the lesion detection capability of DH-PET. With measured attenuation correction the diagnostic performance of DH-PET is closer to that of dedicated ring PET.
    Type of Medium: Electronic Resource
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