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  • Bacterial colonization  (2)
  • Experimental pancreas transplantation, pig, anatomy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Retention of the antibiotic teicoplanin on a hydromer-coated central venous catheter to prevent bacterial colonization in postoperative surgical patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1066-1069 
    Details
    ISSN: 1432-1238
    Keywords: Central venous catheter ; Bacterial colonization ; Antimicrobial coating ; Teicoplanin ; Catheter-related infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective Antibioticcoated intravascular catheters may be an effective means of decreasing bacterial colonization and subsequent catheter-related infection. The present study was designed to investigate the retention of the antibiotic teicoplanin on a hydromer-coated intravenous catheter and the effect of this antibiotic coating on catheter bacterial colonization. Design A prospective, randomized pilot study. Setting Operating rooms (ORs) and an intensive care unit (ICU) at a university hospital. Patients A consecutive group of 20 male patients undergoing major abdominal surgery. Interventions Control (C,n=10) or teicoplanin-coated (T;n=10) single-lumen central venous catheters were inserted before surgery in the OR. Catheters were withdrawn at the discretion of the physicians in the ICU after various periods. Measurements The teicoplanin content of the catheter material was assessed using a bioassay withBacillus subtilis after complete elution of the antibiotic from the catheter. Bacterial colonization was measured using a quanitative culture technique after the catheter lumen had been flushed and the catheter segments sonicated. Main results Nearly three-quarters of the initial teicoplanin coating (374±103 μg; mean±SD) were released during the first day of catheterization, and after 36 h of intravenous catheterization, no antibiotic was retained on the catheter. No significant difference could be found either in the incidence of bacterial colonization between test (n=3) and control (n=4) catheters or in the number of colony-forming units (CFU) on the catheter segments (T, 263±104 CFU/cm; C, 372±294 CFU/cm; mean±SEM). Conclusion The retention of teicoplanin antibiotic coating on hydromer catheters is only short term if catheters are inserted intravenously. This may limit clinical antibacterial efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01699229
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Retention of the antibiotic teicoplanin on a hydromer-coated central venous catheter to prevent bacterial colonization in postoperative surgical patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1066-1069 
    Details
    ISSN: 1432-1238
    Keywords: Key words Central venous catheter ; Bacterial colonization ; Antimicrobial coating ; Teicoplanin ; Catheter-related infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Antibiotic-coated intravascular catheters may be an effective means of decreasing bacterial colonization and subsequent catheter-related infection. The present study was designed to investigate the retention of the antibiotic teicoplanin on a hydromer-coated intravenous catheter and the effect of this antibiotic coating on catheter bacterial colonization. Design: A prospective, randomized pilot study. Setting: Operating rooms (ORs) and an intensive care unit (ICU) at a university hospital. Patients: A consecutive group of 20 male patients undergoing major abdominal surgery. Interventions: Control (C, n=10) or teicoplanin-coated (T; n=10) single-lumen central venous catheters were inserted before surgery in the OR. Catheters were withdrawn at the discretion of the physicians in the ICU after various periods. Measurements: The teicoplanin content of the catheter material was assessed using a bioassay with Bacillus subtilis after complete elution of the antibiotic from the catheter. Bacterial colonization was measured using a quanitative culture technique after the catheter lumen had been flushed and the catheter segments sonicated. Main results: Nearly three-quarters of the initial teicoplanin coating (374±103 μg; mean±SD) were released during the first day of catheterization, and after 36 h of intravenous catheterization, no antibiotic was retained on the catheter. No significant difference could be found either in the incidence of bacterial colonization between test (n=3) and control (n=4) catheters or in the number of colony-forming units (CFU) on the catheter segments (T, 263±104 CFU/cm; C, 372±294 CFU/cm; mean±SEM). Conclusion: The retention of teicoplanin antibiotic coating on hydromer catheters is only short term if catheters are inserted intravenously. This may limit clinical antibacterial efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01699229
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Pancreatic autotransplantation in the pig: variations in epigastric arterial blood supply (1989)
    Springer
    Transplant international 2 (1989), S. 193-198 
    Details
    ISSN: 1432-2277
    Keywords: Pancreas transplantation, in the pig ; Experimental pancreas transplantation, pig, anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A major problem in pancreatic autotransplantation is the vascular supply of the left segment, which serves as the graft. We therefore examined the arterial blood supply of the epigastric organs in 36 German landrace pigs. In 19 pigs (anatomical variation 1) there was a pancreatic branch of the splenic artery supplying the left segment. After splenectomy the splenic artery could be used as the graft-supplying vessel. In 14 pigs (anatomical variation 2) the arterial branch for the left segment was the first branch out of the hepatic artery distal to the coeliac trunk. In these cases a splenohepatic bypass was performed to ensure delivery of the blood to the epigastric organs. Thereafter, the proximal part of the hepatic artery could be used as the vessel supplying the graft. The left segment could not be used for autotransplantation in 3 pigs (anatomical variation 3) because of the atypical vascular supply. During the 6-month observation period, no malfunction of the epigastric organs was evident.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02414533
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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