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  • Bare lymphocyte syndrome  (1)
  • Bis[dicarbonyl(η5-methylcyclopentadienyl)manganese](stibine) complexes  (1)
  • Clinical trial  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Durchführung eines neuen Therapiekonzepts für Nephroblastome im Bereich der Gesellschaft für Pädiatrische Onkologie und Hämatologie SIOP 9/GPOH (1997)
    Springer
    Monatsschrift Kinderheilkunde 145 (1997), S. 128-135 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Nephroblastom ; Klinische Studie ; Präoperative Chemotherapie ; Diagnostische Sicherheit ; Therapiereduktion ; Key words Nephroblastoma ; Clinical trial ; Pre-operative chemotherapy ; Diagnostic accuracy ; Reduction of therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: In a new study the intensity of treatment used in the former Wilms' Tumor Study of the „Gesellschaft für Pädiatrische Onkologie und Hämatologie“ (GPOH) since 1980 had to be reduced maintaining the good results. Methods: 1989 the strategy of the International Society of Pediatric Oncology (SIOP) with pre-operative chemotherapy after diagnostic imaging was adopted. The pretreatment should reduce the tumorsize to allow complete tumor resection in most patients. Results: Of 505 patients enrolled in the study over 5.25 years from 78 participating centers, 486 had a nephroblastoma, 14 another malignant tumor and 5 a benign renal lesion. Of 438 patients with nephroblastoma aged between 0.5 and 16 years 85.4 % received pre-operative chemotherapy. Compared to the prior study the percentage of patients with irradiation (22.8 %) was lowered and the cumulative dose of Adriamycin for higher stages and unfavourable histology reduced. The 91 % probability of crude survival after 3 years for all nephroblastoma patients was similiar to the former study. Conclusions: The concept of general pre-operative chemotherapy for nephroblastoma was accepted by GPOH with evident reduction of treatment intensity compared to the prior study.
    Notes: Zusammenfassung Hintergrund: Die intensive Therapie der von der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) ab 1980 durchgeführten Wilmstumorstudie sollte in der Folgestudie unter Wahrung der guten Ergebnisse reduziert werden. Methode: 1989 wurde das Therapiekonzept der International Society of Pediatric Oncology (SIOP) mit präoperativer Chemotherapie nach bildgebender Diagnose übernommen, wobei der Tumor durch die Vorbehandlung verkleinert wird, damit er bei einem Großteil der Kinder vollständig entfernbar ist. Ergebnisse: Bei 505 in 5,25 Jahren aus 78 Kliniken gemeldeten Patienten hatten 486 ein Nephroblastom, 14 ein anderes Malignom und 5 eine benigne renale Läsion. Von 438 gemeldeten Nephroblastompatienten zwischen 0,5 und 16 Jahren erhielten 85,4 % präoperativ eine Chemotherapie. Der Anteil bestrahlter Nephroblastompatienten (22,8 %) und die kumulative Adriamycindosis bei hohen Stadien bzw. hoher Malignität wurden im Vergleich zur Vorstudie reduziert bei ähnlicher Überlebenswahrscheinlichkeit von 91 % nach 3 Jahren. Schlußfolgerung: Das Konzept einer generellen präoperativen Chemotherapie zur Nephroblastombehandlung ist in der GPOH mit gutem Ergebnis und deutlicher Therapiereduktion im Vergleich zur Vorstudie durchzuführen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050114
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  • 2
    Electronic Resource
    Electronic Resource
    Bare lymphocyte syndrome — combined immunodeficiency and neutrophil dysfunction (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 700-704 
    Details
    ISSN: 1432-1076
    Keywords: Bare lymphocyte syndrome ; HLA expression ; Severe combined immunodeficiency syndrome ; Neutrophil dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 4-year-old girl presented with recurrent infections. Immunoglobulin deficiency (serum and secretory IgA, serum IgG3) neutropenia and neutrophil dysfunction (defective spontaneous migration and chemotaxis) were found. T-lymphocyte counts were normal and they responded to phytohaemagglutinin but were not stimulated by Concanavalin A, pokeweed mitogen and microbial antigens in vitro. Delayed cutaneous hypersensitivity testing to purified protein derivative and candidin was negative. Despite bacille Calmette-Guérm vaccination and candidiasis, near normal β-2-microglobulin and human leucocyte antigen (HLA) class I concentrations were detected on mononuclear cells and phytohaemagglutinin-induced lymphoblasts. HLA class II antigens (HLA-DP, −DQ, −DR) were not expressed. These observations indicated a bare lymphocyte syndrome (BLS) type II. This is the first time neutrophil dysfunction has been noted in association with BLS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959526
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  • 3
    Electronic Resource
    Electronic Resource
    Eisen- und Mangankomplexe mit sauerstoff-, schwefel- und methylen-verbrückten Distibanen und mit Chlorodiphenylstiban als Liganden (1993)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 619 (1993), S. 2061-2065 
    Details
    ISSN: 0044-2313
    Keywords: Dicarbonylbis(triphenylphosphite)(stibine)iron complexes ; Bis[dicarbonylbis(triphenylphosphite)iron](stibine) complexes ; Dicarbonyl(η5-methylcyclopentadienyl)(stibine)manganese complexes ; Bis[dicarbonyl(η5-methylcyclopentadienyl)manganese](stibine) complexes ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Complexes of Iron and Manganese with Oxygen-, Sulfur-, and Methylene-bridged Distibines and with Chlorodiphenylstibine as LigandsThe photochemical reaction of CO3Fe[P(OPh)3]2 and of MeCpMn(CO)3 with the stibines Ph2SbCl and (Ph2Sb)2X (X = O, S and CH2) yields mononuclear complexes (CO)2[P(OPh)3]2FeL and °Cp(CO)2MnL (L = Ph2SbCl, (Ph2Sb)2X) and the stibine bridged binuclear complexes °CO)2[P(OPh)3]2Fe{(Ph2Sb)2X}Fe(CO)2[P(OPh)3]2 and °Cp(CO)2Mn{(Ph2Sb)2X}Mn(CO)2MeCp.
    Notes: Durch photochemische Umsetzung von (CO)3Fe[P(OPh)3]2 und von MeCpMn(CO)3 mit Anti-monliganden des Typs Ph2SbCl und (Ph2Sb)2X (X = O, S und CH2) können Einkernverbindungen (CO)2[P(OPh)3]2FeL und MeCp(CO)2MnL (L = Ph2SbCl, (Ph2Sb)2X sowie die über Distibanliganden verbrückten Zweikernverbindungen (CO)2[P(OPh)3]2Fe{(Ph2Sb)2X}Fe(CO)2[P(OPh)3]2 und MeCp(CO)2Mn{(Ph2Sb)2X}Mn(CO)2MeCp synthetisiert werden.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19936191215
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    Paper (German National Licenses)
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