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  • Best. von Eisen, Cobalt, Kupfer, Zink, Selen, Rubidium, Cäsium in Leber, Blutplasma, Erythrocyten, Normalbereiche, Neutronenaktivierungsanalyse, Gammaspektrometrie, Atomabsorptionsspektrometrie  (1)
  • Graft survival rate  (1)
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  • 1
    ISSN: 1432-1440
    Keywords: MHC ; Cadaver kidney transplantation ; Graft survival rate ; Blood transfusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of prospective HLA-DR matching on the graft survival rate was investigated in a multicenter analysis of 85 transplants. Simultaneously in a retrospective analysis of graft outcome the importance of matching for MT-antigens MT1, MT2 and MT3 as a newly defined B-cell alloantigen system was evaluated. HLA-DR antigens and MT-specificities were determined on B-cells enriched by nylon-wool filtration using locally well characterised HLA-DR antisera and the antiserum set of the 8th International Histocompatibility Workshop (“discase set”) which allowed the definition of the HLA-DR specificities HLA-DR 1–9 and of the MT-antigens MT 1–3. HLA-DR matching showed a significantly improved graft outcome only in HLA-DR identical donor-recipient combinations. In 11 of 60 patients with one HLA-DR compatibility additional matching for two MT-antigens, however, improved the two year graft survival rate from 60% to 91%. Altogether 17 patients were matched for two MT-specificities with their kidney donor and showed a superior prognosis of 94% at two years compared to 53% or 17% of recipients with one or zero MT compatibility. Graft outcome in this patient group was also superior to that of HLA-DR identical or HLA-AB identical grafts. These data suggested that the MT-system rather than the HLA-DR antigens may be of critical importance in cadaver kidney transplantation. In addition a favorable influence of pretransplant blood transfusions on less HLA-DR matched grafts was confirmed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 305 (1981), S. 399-404 
    ISSN: 1618-2650
    Keywords: Best. von Eisen, Cobalt, Kupfer, Zink, Selen, Rubidium, Cäsium in Leber, Blutplasma, Erythrocyten, Normalbereiche, Neutronenaktivierungsanalyse, Gammaspektrometrie, Atomabsorptionsspektrometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Der Gehalt von Fe, Co, Cu, Zn, Se, Rb und Cs wurde in Blutplasma und in Erythrocyten von sechs Normalpersonen mittels der instrumentellen Neutronenaktivierungsanalyse und der flammenlosen Absorptionsspektrometrie (Cu) bestimmt. Zur Überprüfung der Richtigkeit wurde der NBS-Standard 1577, Ochsenleber, verwendet. Die erhaltenen Resultate für Elemente mit höheren Gehalten (Fe, Cu, Zn) liegen weitgehend im Bereich der bisher veröffentlichten Daten. Bei Elementen mit kleineren Gehalten (Co, Se, Rb, Cs) liegen unsere Werte in dem unteren Bereich oder darunter. Für diese Elemente wurden in Blutplasma und in Erythrocyten (hier bezogen auf Trockenmasse) die folgenden Mittelwerte ermittelt: Für Co 0,22 ±0,14 ng/ml, 0,59±0,23 ng/g, für Se 103±18 ng/ml, 401±29 ng/g, für Rb 167±36 ng/ml, 12,1±2,5 μg/g und für Cs 0,88±0,18 ng/ml, 13,0±5,7 ng/g.
    Notes: Summary The content of the above elements has been determined in blood plasma and in erythrocytes of six normal persons by instrumental neutron activation analysis and flameless atomic absorption spectrometry (Cu). The over-all accuracy of these techniques was checked by using the NBS standard 1577, Bovine Liver. The results obtained for elements of higher content (Fe, Cu, Zn) are essentially in the range of other published data. However, our results for elements occurring with lower contents (Co, Se, Rb, Cs) are in agreement with the lowest values of the published data and in some cases they are even significantly below these. For these elements, the following contents have been determined in blood plasma and in erythrocytes (here related to dry weight): for Co 0.22±0.14 ng/ml and 0.59±0.23 ng/g, for Se 103±18 ng/ml and 401±29 ng/g, for Rb 167 ±36 ng/ml and 12.1±2.5 μg/g and for Cs 0.88 ±0.18 ng/ml and 13.0±5.7 ng/g, respectively.
    Type of Medium: Electronic Resource
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