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  • 1
    Electronic Resource
    Electronic Resource
    Results of oral TRH test in the differentiation of compensated and decompensated autonomous thyroid nodules (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 477-478 
    Details
    ISSN: 1432-1440
    Keywords: Autonomous thyroid nodules ; Oral TRH test ; Results ; Autonomes Adenom ; Oraler TRH-Test ; Ergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 17 Patienten mit kompensierten autonomen Adenomen der Schilddrüse wurden TRH-Teste mit 200 µg i.v. und 40 mg oral durchgeführt. Bei 9 Patienten war TSH 30 min nach TRH i.v. normal (〉2.7 µU/ml), dagegen zeigten 8 Patienten einen subnormalen (〈2.7 µU/ml) oder fehlenden TSH-Anstieg. Nach verlängerter Stimulation mit 40 mg TRH oral war TSH 120–180 min bei 15 Patienten im Normbereich (〉2.7 µU/ml) und nur bei 2 Patienten subnormal (〈2.7 µU/ml). Bei 20 Patienten mit dekompensierten autonomen Adenomen der Schilddrüse lag TSH sowohl nach i.v. als auch nach oraler TRH-Stimulation in allen Fällen unter der Nachweisgrenze (〈0.8 µU/ml). Die Befunde sprechen dafür, daß der orale TRH-Test geeigneter ist als der i.v. TRH-Test, um zwischen kompensierten und dekompensierten autonomen Adenomen der Schilddrüse zu unter-scheiden.
    Notes: Summary In 17 patients with compensated autonomous adenomas of the thyroid, iv thyrotropin releasing hormone (TRH) tests (200 µg) and oral TRH tests (40 mg) were performed. In nine of these patients, thyroid-stimulating hormone (TSH) 30 min after iv TRH showed a normal (〉2.7 µU/ml) and in eight patients a subnormal (〈2.7 µU/ml) or negative response. However, after prolonged oral stimulation with 40 mg TRH, after 120–180 min TSH was normal (〉2.7 µU/ml) in 15 and subnormal (〈2.7 µU/ml) in two patients. In 20 patients with decompensated autonomous thyroid nodules, TSH was not detectable (〈0.8 µU/ml) after iv or oral TRH stimulation. Therefore, the oral TRH stimulation test seemed to be superior to the iv TRH test in the discrimination of compensated and decompensated autonomous adenomas of the thyroid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720363
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  • 2
    Electronic Resource
    Electronic Resource
    Die 131-Jod-Hippuranclearance zur Erfassung der nephrotoxischen Wirkung von cis-Dichlorodiamino-Platin (II) (cis-Platin, cis-DDP) (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 561-566 
    Details
    ISSN: 1432-1440
    Keywords: Cis-dichlorodiammine-platinum (II) ; Nephrotoxicity ; Iodo-131-hippurate-clearance ; Serum creatinine ; Creatinine clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 25 patients, who received repeated doses of cis-DDP, we determined iodo-131-hippurate-clearance, creatinine clearance and serum creatininc to assess the nephrotoxic effect induced by cis-DDP. A highly significant decrease in the iodo-131-hippurate-clearance was found between the first and the following cycles. There was no significant change in serum creatinine and creatinine clearance however. The radio-hippurate-clearance showed a clinically not important reduction during several cytotoxic courses in 15/25 patients (60%). A clinically relevant impairment of the radio-hippurate-clearance occurred in 8/25 patients (32%), mainly before the third and fifth cytotoxic cycle. In two patients this clearance did not alter or was even rising. In 12 cases a diminuation of the iodo-131-hippurate-clearance was observed, which in only 5 cases correlated to a decreased creatinine clearance and in only two cases to an elevated serum creatinine. Therefore, we consider neither creatinine nor creatinine clearence nor the combination of both parameters to be appropriate to assess tubular nephropathy induced by cis-DDP. Radio-hippurate-clearance should play a superior role deciding on treatment stop or dose reduction of cis-DDP. The regression of cis-DDP-induced nephropathy was not evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486846
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  • 3
    Electronic Resource
    Electronic Resource
    Reduced technetium 99m labelled NCA-95/CEA-antibody uptake in liver due to gentle antibody reconstitution (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 38-41 
    Details
    ISSN: 1619-7089
    Keywords: Monoclonal antigranulocyte antibody ; NCA-95-specific antibody ; Bone marrow scintigraphy ; Antibody liver uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of reconstituting a murine monoclonal IgG1 antibody kit with pertechnetate technetium 99m on antibody distribution in the liver, spleen and sternal bone marrow of patients was examined. The99mTc-labelled antibody used is directed against nonspecific cross-reacting antigen (NCA-95) and carcinoembryonic antigen (CEA) and has been successfully applied for imaging tissue inflammation and bone marrow scanning. Radioactivity uptake was determined in the liver, spleen, bone marrow and a precordial background region in a consecutive series of 25 patients, examined with an antibody preparation, routinely radiolabelled according to the manufacturer's recommendations and in 14 patients, in whom the antibody was reconstituted with special care, avoiding bubble formation and dropping of buffer into the antibody-containing vial. Gentle compared with routine antibody reconstitution caused a highly significant reduction of the antibody uptake in the liver, as determined by count densities, normalized to injected dose and acquisition time (13.2 ± 5.5 vs 20.1 ± 6.0 cpm per pixel, x±SID,P=0.008). The liver to background ratio was reduced from 3.4 ± 1.4 to 1.9 ±0.5 (P 〈 0.001). Spleen, sternal bone marrow and precordial background count rates were not significantly affected. These results clearly demonstrate that gentle antibody reconstitution can decrease non-specific antibody uptake in the liver by 34% ± 6.4% (x ± SEM). Thus, scan quality is improved, and the potential deleterious camouflage of underlying structures is avoided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00819402
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    Paper (German National Licenses)
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