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  • Colorectales Carcinom  (2)
  • Follow-up  (2)
  • C. symbiosum  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 138 (1984), S. 179-182 
    ISSN: 1432-072X
    Keywords: Citrate utilization ; Fermentation products ; Citrate lyase activity ; Clostridium sporosphaeroides ; C. symbiosum ; C. rectum ; C. indolis ; C. subterminale ; C. sporogenes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 44 species of the genus Clostridium were examined with regard to their ability to grow on citrate. In addition to Clostridium sphenoides, a known citrate utilizer, the following species were found to utilize citrate: C. sporosphaeroides, C. symbiosum, C. rectum, C. indolis, C. subterminale and C. sporogenes. The major products formed from citrate were acetate, ethanol and carbon dioxide (not measured). Minor products were butyrate, butanol, acetone and acetoin. The enzyme citrate lyase was detectable in cell extracts of C. sporosphaeroides and C. symbiosum using an optical assay. Evidence for the presence of this enzyme in the other species was obtained in immunological experiments and in experiments with [1,5-14C]citrate.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 628-628 
    ISSN: 1435-2451
    Keywords: Colorectal cancer ; Follow-up ; CEA ; Second-look operation ; Colorectales Carcinom ; Nachsorge ; CEA ; Second Look Operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 1978–1980 wurden 155 Patienten nach potentiell kurativer Operation wegen colorectalen Carcinoms nach einem tumor-spezifischen Nachsorgeprogramm nachuntersucht. Bei 22 von 26 Patienten mit Rezidiv, Fernmetastasen bzw. Zweitcarcinom war der CEA-Test frühester diagnostischer Hinweis, im Mittel 5,5 Monate vor Sicherung der Diagnose. Bei 8 von 10 Second Look Operationen ausschließlich auf Grund des auffälligen CEA-Verlaufes wurden ein Rezidiv bzw. Fernmetastasen intraabdominell gefunden. Bei 16 Patienten erfolgte eine operative Sekundärtherapie, 9mal potentiell kurativ.
    Notes: Summary Between 1978 and 1980 a follow-up study was performed with 155 patients after a curative operation for colorectal cancer. In 26 cases recurrent disease or a second colorectal cancer was diagnosed. In 22 cases the CEA test was the first sign of tumor progression in the mean 5.5 months before clinical diagnosis. In 8 of 10 second-look operations, intraabdominal tumor relapse was found. Of the 16 patients operated on a second time, 9 are potentially curable.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-2451
    Keywords: Gastric cancer ; Tumor marker ; Diagnosis ; Follow-up ; Magen-Ca ; Tumormarker ; Diagnose ; Verlaufsbeobachtung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Präoperative Seren von 130 Magen Ca.-Patienten (Stad. I–IV, TNM-Klassifikation) wurden auf die Konzentration von Ca 19-9 (pos. ≧ 25 U/ml) und CEA (pos. ≧ 5 ng/ml) hin un tersucht. 55 Patienten mit gutartigen Erkrankungen dienten als Kontrollen. 27/130 Patienten hatten erhöhte CEA und nur 20/130 Patienten pathologisch erhöhte Ca 19-9 Werte. Wertet man aber die Kombination beider Marker - Ca 19-9 und/oder CEA pathologisch erhöht - als positiven Befund, so sind 38/130 Patienten tumormarker-positiv. Bei der Tumornachsorge ergaben sich bei 16/18 Patienten mit Rezidiv oder Fernmetastase eines Magen Ca. pathologische Markerbefunde (7 Patienten nur CEA pos., 4 Patienten nur Ca 19-9 pos. und 5 Patienten CEA und Ca 19-9 pos.).
    Notes: Summary The preoperative sera of 130 gastric cancer patients (stages I–IV, TNM classification) were assayed for Ca 19-9 (positive ≧ 25 U/ml) and CEA (positive ≧ 5 ng/ml); 55 patients with benign diseases served as controls. Of the 130 patients, 27 exhibited elevated CEA values, and only 20/130 had pathologically elevated CA 19-9 values. In contrast, the combination of both tests increased the sensitivity (38/130 patients positive) if a positive result means that when either or both markers are positive, the result is positive. In the follow-up situation, 16/18 patients with recurrent or metastatic gastric cancer were marker positive (7 patients only CEA pos., 4 patients only Ca 19-9 pos., and 5 patients CEA and Ca 19-9 pos.).
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 625-625 
    ISSN: 1435-2451
    Keywords: Colorectal cancer ; Recurrence ; Reoperation ; CEA ; Colorectales Carcinom ; Rezidiv ; Chirurgische Therapie ; CEA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 1978–1984 wurden 87 Patienten wegen lokoregionärer Rezidive (35) und metachroner Fernmetastasen (52) colorectaler Carcinome operiert. 28,6% der Patienten mit Rezidiven und 46,2% der Patienten mit Metastasen konnten potentiell kurativ therapiert werden. Zum Zeitpunkt der gesicherten Diagnose hatten 73/87 Patienten einen erhöhten CEA-Wert (≧5 ng/ml). Bei 65/73 Patienten ging der CEA-Ànsbeg der Diagnose voraus. Bei 14 Patienten wurde die Diagnose erst durch eine Second-Look-Operation gesichert. Rezidivpatienten (71,4%) wiesen gegenüber Patienten mit Metastasen (92,3%) seltener erhöhte CEA-Werte auf. Die CEA-Werte der potentielle kurativ operablen Patienten (median 19,7 ng/ml) waren signifikant niedriger (p 〈 0,05) als bei Patienten mit inoperablen Befunden (median 36,9 ng/ml).
    Notes: Summary Between 1978 and 1984, 87 patients with recurrent colorectal cancer have been operated upon. In 10 of 35 patients with locoregional recurrence and 24 of 52 with distant metastases, the therapy was potentially curative. Of 87 patients, 73 had elevated CEA levels (≧ 5 ng/ml) at the time of diagnosis. In 65 of 73 patients, the CEA increase preceded the recognition of recurrence and in 14 patients the diagnosis could be confirmed only by a second-look operation. Patients with metastases (91.3%) showed CEA elevation more often than those with locoregional recurrence (71.4%). Patients with operable disease had significantly (p 〈 0.05) lower CEA values (median 19.7 ng/ml) than those with inperable recurrent carcinomas (median 36.9 ng/ml).
    Type of Medium: Electronic Resource
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