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  • 1
    Electronic Resource
    Electronic Resource
    Influence of pantothenic acid deficiency on the amount of CRF-granules in the rat median eminence (1974)
    Springer
    Anatomy and embryology 146 (1974), S. 43-55 
    Details
    ISSN: 1432-0568
    Keywords: Pantothenic acid deficiency ; Corticotropin-releasing factor ; Corticoids ; Histologie ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the outer layer of the rat median eminence “Gomori-positive” granules occur which are assumed to be the morphological correlate of the corticotropin-releasing factor (CRF). The present study was carried out in order to establish whether the amount of these CRF-granules is influenced by a pantothenic acid (PA)-deficiency, which is known to result in an inhibition of corticosteroid production. Female SPF Wistar rats were used. PA-deficiency was induced by PA-free nutrition and/or administration of the PA-antagonist Ω-methyl-PA. Corresponding experimental groups were given either tap water or a solution of 1% NaCl and 5% glucose in tap water to drink. In rats fed with a diet free of PA and in addition treated with Ω-methyl-PA a severe disturbance of the corticoid balance developed within 6 weeks. The corticosterone production was depressed to about 11–16% of the control values. The adrenal cortex showed necrotic changes which either involved the whole parenchyma or were confined to the inner zones. In those animals in which a subcapsular region, in its extent corresponding to the zona glomerulosa, remained intact, an augmentation of the CRF-granules was observed. In those animals, however, in which the whole adrenal cortex was damaged, the amount of CRF-granules did not increase. Administration of the 1% NaCl containing drinking fluid did not influence the augmentation of the CRF granules, but had a protective effect on the development of necrotic changes in the zona glomerulosa of the adrenal cortex. The findings show that a functional relationship exists between the inner zones of the adrenal cortex and the CRF-granules in the median eminence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341382
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of various corticoids on the augmentation of “Gomori-positive” granules in the median eminence of the rat following adrenalectomy (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 280 (1973), S. 49-62 
    Details
    ISSN: 1432-1912
    Keywords: Corticotropin-Releasing Factor ; Corticoids ; Median Eminence ; Rat ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 465 female Wistar rats the influence of an i.m. injection of various natural or synthetic corticoids on the augmentation of “Gomori-positive” granules in the outer layer of the median eminence following bilateral adrenalectomy has been investigated. While the augmentation of the granules is not impaired by progesterone it is inhibited or completely blocked, depending on the dose and the manner of application, by 11-desoxycorticosterone, corticosterone, cortisol, 9α-fluorocortisol, prednisolone, triamcinolone, dexamethasone and fluoroformylone. The doses necessary to suppress the augmentation of the granules correspond to those shown by other authors to be required for blocking ACTH-secretion. The inhibitory effect of the investigated corticoids on the augmentation of the granules is related to their antiphlogistic potency. The findings suggest that the amount of the “Gomori-positive” granules in the outer layer of the median eminence of the rat might be used as a parameter of the activity of the corticotropin-releasing factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505354
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of salt loading and salt deprivation on the vasopressin and oxytocin content of the median eminence and the neural lobe in adrenalectomized rats (1986)
    Springer
    Cell & tissue research 246 (1986), S. 413-423 
    Details
    ISSN: 1432-0878
    Keywords: Vasopressin ; Oxytocin ; Neurohypophysis (Median eminence, Neural lobe) ; Adrenalectomy ; Salt loading ; Salt deprivation ; Plasma volume ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In adrenalectomized rats the influence of salt loading or salt deprivation on the vasopressin and oxytocin content of the median eminence (ME) and the neural lobe (NL) was studied by means of various methods: (1) morphometric and microphotometric analysis of aldehyde fuchsin-stained sections of ME and NL; (2) immunohistochemical demonstration of neurophysin, oxytocin, and vasopressin in the ME and in the NL; (3) radioimmunological measurement of oxytocin and vasopressin in the ME and in the NL. Adrenalectomy in salt-substituted rats raised the vasopressin content of the outer layer of the ME (OLME) but had no influence on the amount of vasopressin in the inner layer of the ME and in the NL. Osmotic stimulation of adrenalectomized rats by hypertonic saline markedly diminished vasopressin and oxytocin in the inner layer of the ME and in the NL but did not, or only slightly reduced vasopressin in the OLME. Withdrawal of salt supplementation in adrenalectomized rats resulted in a decrease of plasma sodium and plasma volume. It did not change the vasopressin or oxytocin content of the inner layer of the ME and of the NL, but it was correlated with a decrease of vasopressin in the OLME. The present findings may suggest that vasopressin in the OLME is involved in salt and/or volume regulation by influencing the hypophysial-adrenal axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215904
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of adrenalectomy and administration of hypertonic saline on the content of aldehyde fuchsin-positive neurosecretory material and posterior lobe hormones in the median eminence and the neural lobe of rats (1983)
    Springer
    Cell & tissue research 228 (1983), S. 127-138 
    Details
    ISSN: 1432-0878
    Keywords: Vasopressin ; Oxytocin ; Neurophysin ; Neurohypophysis ; Adrenalectomy ; Osmotic stress ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The influence of adrenalectomy and administration of hypertonic saline on the amount of vasopressin, oxytocin, and neurophysin contained in the median eminence and the neural lobe of rats was studied by means of the following methods: (i) morphometric and microphotometric analyses of aldehyde fuchsin-stained histological sections of the neurohypophysis; (ii) immunohistochemical demonstration of vasopressin, oxytocin, and neurophysin in the neurohypophysis, and (iii) radioimmunological measurement of vasopressin and oxytocin in extracts of the median eminence and the neural lobe. Adrenalectomy increases the amount of vasopressin and neurophysin in the external layer of the median eminence but does not change the content of oxytocin. It has no influence on the amount of vasopressin, oxytocin, and neurophysin demonstrable in the inner layer of the median eminence and in the neural lobe two weeks after the operation. Hypertonic saline markedly diminishes the vasopressin, oxytocin, and neurophysin content of the inner layer of the median eminence and the neural lobe but reduces only slightly, if at all, the amount of vasopressin and neurophysin in the outer layer of the median eminence. The findings support the concept that osmotic stress reduces only the vasopressin and oxytocin content of the hypothalamus-neural lobe system and has no or only little influence on the vasopressin content of the outer layer of the median eminence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206271
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    Paper (German National Licenses)
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