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  • Hodgkin's disease  (3)
  • Data management quality control  (1)
  • Elektrodermal activity  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Behandlungsergebnisse mit dem ABVD-Schema bei C-MOPP-resistentem Morbus Hodgkin (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 267-273 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Hodgkin's disease ; MOPP-failures ; ABVD ; Morbus Hodgkin ; MOPP-Resistenz ; ABVD
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung 22 Patienten wurden mit dem ABVD-Protokoll behandelt. 19 (18 × IV B, 1 × III B) sind auswertbar. Kein Patient mit eingeschränkter, aber 7 von 13 Patienten mit intakter Knochenmarksfunktion erreichten eine Vollremission. Alle vier Patienten mit therapie- und krankheitsfreiem Intervall aber nur von 3 von 13 Patienten ohne freies Intervall erreichten ebenfalls eine Vollremission. Vorbehandlung, Histologie, Dauer der Erkrankung und Lebensalter hatten keinen eindeutigen Einfluß auf die Remissionszahlen. Die Toxizität war insbesondere bei über 50-jährigen Patienten erheblich. Zwei Patienten dieser Altersgruppe brachen die Therapie wegen gastrointestinaler Nebenwirkungen ab und 2 von 8 starben an ABVD-mitverursachten Erkrankungen (1 Leukämie, 1 plötzlicher Herztod). Bei drei Patienten mit hochdosierter Mediastinalbestrahlung war eine Pneumonitis eine der wesentlichen Todesursachen. Nach unseren Ergebnissen ist ABVD ein effektives Chemotherapieprotokoll für einige Subgruppen der „MOPP-Versager“.
    Notizen: Summary 22 patients were treated with ABVD, 19 (18 stage IV B 1 stage III B) could be evaluated. No patient with impaired but 7 of 13 patients with intact bone-marrow function achieved a complete remission. A complete remission was also achieved by all 4 patients with a treatment- and disease-free interval but only by 3 of 15 without a free interval. Pretreatment, histology, duration of disease, and age showed no clear prognostic significance with respect to induction of remission. Toxicity was severe especially in patients over 50 years of age. 2 patients discontinued therapy because of gastro-intestinal toxicity. 2 of 8 died of treatment-related causes (1 leukemia, 1 sudden cardiac death). In 3 patients with high-dose mediastinal irradiation a pneumonitis secondary to bleomycin contributed significantly to death. Our results suggest that ABVD is an effective salvageregimen for some subgroups of MOPP-failures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01478205
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  • 2
    Digitale Medien
    Digitale Medien
    Gefühl ohne Sprache oder Sprache ohne Gefühl? Weitere Hinweise auf die Validität der Entkopplungshypothese der Alexithymie (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 216-224 
    Details
    ISSN: 1433-0407
    Schlagwort(e): Schlüsselwörter Alexithymie ; Entkopplungshypothese ; Key words Alexithymia ; Elektrodermal activity ; Decoupling hypothesis ; Dissociation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary The theoretical background of the present investigation was the decoupling hypothesis of alexithymia, which presumes for alexithymic individuals a dissociation of psychophysiological indicators of emotion from verbal cognitive awareness of one’s emotional state. To study alterations in reactivity to emotionally distressing stimuli in alexithymic individuals, 12 high-alexithymic and 14 low-alexithymic subjects (separated by TAS) out of a general sample of 54 were investigated. All subjects were exposed to cognitive (CPT) and affect inductive (film sequences) distress. During stimulus exposition electrodermal activity (sponateous fluctuations) was recorded. After stimulus exposition the subjects assessed their emotional reaction towards the film sequences (DAS). Concerning electrodermal activity no differences were found between high and low alexithymics under cognitive distress. In any case a significant autonomous arousal was registered. However, only the low alexithymic subjects but not the high alexithymics showed a significant increase of spontaneous fluctuations as expression of autonomous arousal during presentation of affect inductive stimuli. The altered psychophysiological reactivity found in high alexithymics in contrast to low alexithymic subjects was revealed specifically for the processing of emotional qualified stimuli. However, there was no difference between the groups in cognitive self assessment of emotional response towards the film sequences. The findings are discussed with reference to neurophysiological and psychodynamic models and the decoupling hypothesis of alexithymia.
    Notizen: Zusammenfassung Theoretischer Hintergrund dieser Untersuchung ist die sog. Entkopplungshypothese der Alexithymie. Diese postuliert für alexithyme Individuen eine Dissoziation psychophysiologischer Aktivierungsprozesse und des subjektiven Affekterlebens speziell unter affektinduktiven Belastungen. 12 hochalexithyme und 14 niedrigalexithyme Probanden aus einer Gesamtstichprobe von 54 Individuen wurden bezüglich der elektrodermaler Spontanfluktuationsrate unter affektneutraler (Reiz-Reaktions-Aufgabe) und affektinduktiver Stimulierung (Videofilme) untersucht. Ihr Affekterleben während der Filmbetrachtung schätzten die Probanden selbst ein. Unter kognitiver Belastung bestanden hinsichtlich der elektrodermalen Aktivierung keine Gruppenunterschiede. Es kam in jedem Falle zu einem signifikanten Anstieg der Spontanfluktuationsrate. Unter affektinduktiver Belastung kam es jedoch nur bei den Niedrigalexithymen nicht aber bei den hochalexithymen Probanden zu einem signifikanten Anstieg der Spontanfluktuationsrate als Ausdruck einer autonomen Aktivierung. In der Bewertung ihres reizbezogenen Affekterlebens unterschieden sich die Gruppen nicht. Diese Befunde sind in Übereinstimmung mit der Entkopplungshypothese, und werden im Hinblick auf neuropsychologische und psychodynamisch-interaktionsdynamische Modellvorstellungen diskutiert.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001150050425
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  • 3
    Digitale Medien
    Digitale Medien
    High-dose chemotherapy and hematopoietic stem cell rescue in patients with relapsed Hodgkin's disease (1993)
    Springer
    Annals of hematology 66 (1993), S. 251-256 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Hodgkin's disease ; High-dose therapy ; Bone marrow transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Fifty-one consecutive patients with Hodgkin's disease (HD) have been treated with high-dose chemotherapy (HDT) and transplantation of autologous bone marrow (BM) (n=44), autologous BM plus peripheral blood stem cells (PBSC) (n=2), PBSC (n=1), syngeneic (n=1), or allogeneic BM (n=3). All patients had received standard salvage chemotherapy prior to HDT and were classified as sensitive (n=33) or resistant (n=17) to this treatment; one patient was in untreated relapse prior to BMT. The preparative regimens for patients receiving autologous BM and/or PBSC consisted of cyclophosphamide, VP 16, and BCNU (CVB) (n=44) or BCNU, etoposide, ara-C, and melphalan (BEAM) (n=3). The patients receiving allogeneic transplants were treated with the CVB regimen (n=2) or busulfan (16 mg/kg body wt.) and cyclophosphamide (200 mg/kg body wt.). With a median follow-up of 12 months, overall survival for 44 patients grafted with autologous BM is 61%±9%, progression-free survival for patients with sensitive disease is 44%±11%; no patient with resistant relapse survived beyond 1 year post transplant. Two of three patients grafted with allogeneic BM still survive 15 and 24 months after BMT with Karnofsky performance scores of 70% and 100%, respectively. The main toxicity encountered with the CVB regimen was interstitial pneumonia (IP), seen in four of 15 patients (27%) receiving ≥600 mg/m2 of BCNU. Three of these patients have died. The results show that HDT followed by hematopoietic stem cell rescue may effectively salvage an important fraction of patients with relapsed HD who respond to standard chemotherapy. The same approach is largely unsuccessful in patients with proven refractoriness to standard chemotherapy. Whether HDT followed by BMT or PBSC support is superior to intensive chemotherapy without stem cell support can be answered only by a prospectively randomized trial.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01738475
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  • 4
    Digitale Medien
    Digitale Medien
    Transplant activities in Germany in 1998 – a survey facilitated by the National Registry for Hemopoietic Stem Cell Transplantation (2000)
    Springer
    Annals of hematology 79 (2000), S. 437-443 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Blood stem cell transplantation ; Data management quality control
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  To improve the infrastructure of hemopoietic stem-cell transplantations in our country, the German Registry for Hemopoietic Stem-Cell Transplantations (DRST) was established in 1998. The present paper summarizes the current status of the DRST and gives a survey of transplant activities in Germany in 1998 in terms of transplant units, transplant types, transplant frequencies and underlying diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002770000194
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  • 5
    Digitale Medien
    Digitale Medien
    Prognostic factors in COPP-treated patients with Hodgkin's disease (1982)
    Springer
    Annals of hematology 44 (1982), S. 339-348 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Hodgkin's disease ; Risk factors ; Staging system ; Chemotherapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a recently published review of the literature [40] we came to the conclusion that the Ann-Arbor staging classification is of limited prognostic value for chemotherapy of Hodgkin's disease (Table 2). Four risk factors accounted for impaired complete remission rates: stage IVB, lymphocyte depletion or not classifiable histologic type, previous chemotherapy, and older age. Fifty-eight evaluable patients were treated with COPP; 23 reached a complete remission (40%). Disease-free survival was 31%, overall survival 49% after five years [33]. Besides the known risk factors, impaired bone marrow function (leucocyte counts 〈4×109/1, platelet counts 〈100×109/1) at the start of therapy was associated with poor treatment results: none of six patients achieved a complete remission [41]. Eleven of 16 patients with no and 11 of 23 patients with one risk factor achieved a complete remission, as did only one patient with more than one risk factor. Survival rates after 30 months were; 87% with no, 66% with one, 36% with two, and 13% with more than two risk factors. We can conclude from our results that the prognosis of patients undergoing chemotherapy for Hodgkin's disease depends on the number of risk factors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00319917
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