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  • Hodgkin's disease  (3)
  • therapy  (2)
  • Data management quality control  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Stem-cell transplantation for chronic lymphocytic leukemia: The 1999 perspective (2000)
    Springer
    Annals of oncology 11 (2000), S. 49-53 
    Details
    ISSN: 1569-8041
    Schlagwort(e): CLL ; therapy ; stem-cell transplantation ; prognosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background:The use of myeloablative intensive therapy followedby autologous or allogeneic stem-cell transplantation (SCT) for treatment ofchronic lymphocytic leukemia (CLL) has largely increased over the last years. Design:The present overview updates the available clinicalresults and discusses important aspects of SCT in patients with CLL includingthe type of SCT (autologous vs. allogeneic), myeloablative regimens, purging,the predictive value of molecular monitoring of residual disease, andprognostic factors for the outcome of transplant approaches. Results:With appropriate supportive care, autologous SCT is safeand can induce long-lasting clinical and molecular remissions, which mayimprove the prognosis of patients with CLL. Feasibiliy and efficacy ofautologous SCT appears to be best early during the course of the disease, butit is still unclear if autotransplantation can cure the disease even in thisfavorable subgroup. The role of purging is still unclear. The better diseasecontrol observed after allografting appears to be due tograft-versus-leukemia activity and may allow cure in at least asubset of poor-risk patients. Due to the extraordinarily hightreatment-related mortality, however, the outcome after allogeneic SCT isstill inferior to that after autologous SCT. Conclusions:Autologous transplantation is a valuable treatmentoption for younger patients with early or sensitive poor-risk CLL. Selectedpatients with advanced poor-risk disease and low probability of successfulauto-SCT should be considered for allografting. However, it must be kept inmind that both autologous and allogeneic stem-cell transplantation are stillexperimental procedures and clinical trials further elucidating their valuein the treatment of patients with CLL are warranted.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008308510588
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  • 2
    Digitale Medien
    Digitale Medien
    Behandlungsergebnisse mit dem ABVD-Schema bei C-MOPP-resistentem Morbus Hodgkin (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 267-273 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Hodgkin's disease ; MOPP-failures ; ABVD ; Morbus Hodgkin ; MOPP-Resistenz ; ABVD
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung 22 Patienten wurden mit dem ABVD-Protokoll behandelt. 19 (18 × IV B, 1 × III B) sind auswertbar. Kein Patient mit eingeschränkter, aber 7 von 13 Patienten mit intakter Knochenmarksfunktion erreichten eine Vollremission. Alle vier Patienten mit therapie- und krankheitsfreiem Intervall aber nur von 3 von 13 Patienten ohne freies Intervall erreichten ebenfalls eine Vollremission. Vorbehandlung, Histologie, Dauer der Erkrankung und Lebensalter hatten keinen eindeutigen Einfluß auf die Remissionszahlen. Die Toxizität war insbesondere bei über 50-jährigen Patienten erheblich. Zwei Patienten dieser Altersgruppe brachen die Therapie wegen gastrointestinaler Nebenwirkungen ab und 2 von 8 starben an ABVD-mitverursachten Erkrankungen (1 Leukämie, 1 plötzlicher Herztod). Bei drei Patienten mit hochdosierter Mediastinalbestrahlung war eine Pneumonitis eine der wesentlichen Todesursachen. Nach unseren Ergebnissen ist ABVD ein effektives Chemotherapieprotokoll für einige Subgruppen der „MOPP-Versager“.
    Notizen: Summary 22 patients were treated with ABVD, 19 (18 stage IV B 1 stage III B) could be evaluated. No patient with impaired but 7 of 13 patients with intact bone-marrow function achieved a complete remission. A complete remission was also achieved by all 4 patients with a treatment- and disease-free interval but only by 3 of 15 without a free interval. Pretreatment, histology, duration of disease, and age showed no clear prognostic significance with respect to induction of remission. Toxicity was severe especially in patients over 50 years of age. 2 patients discontinued therapy because of gastro-intestinal toxicity. 2 of 8 died of treatment-related causes (1 leukemia, 1 sudden cardiac death). In 3 patients with high-dose mediastinal irradiation a pneumonitis secondary to bleomycin contributed significantly to death. Our results suggest that ABVD is an effective salvageregimen for some subgroups of MOPP-failures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01478205
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  • 3
    Digitale Medien
    Digitale Medien
    High-dose chemotherapy and hematopoietic stem cell rescue in patients with relapsed Hodgkin's disease (1993)
    Springer
    Annals of hematology 66 (1993), S. 251-256 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Hodgkin's disease ; High-dose therapy ; Bone marrow transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Fifty-one consecutive patients with Hodgkin's disease (HD) have been treated with high-dose chemotherapy (HDT) and transplantation of autologous bone marrow (BM) (n=44), autologous BM plus peripheral blood stem cells (PBSC) (n=2), PBSC (n=1), syngeneic (n=1), or allogeneic BM (n=3). All patients had received standard salvage chemotherapy prior to HDT and were classified as sensitive (n=33) or resistant (n=17) to this treatment; one patient was in untreated relapse prior to BMT. The preparative regimens for patients receiving autologous BM and/or PBSC consisted of cyclophosphamide, VP 16, and BCNU (CVB) (n=44) or BCNU, etoposide, ara-C, and melphalan (BEAM) (n=3). The patients receiving allogeneic transplants were treated with the CVB regimen (n=2) or busulfan (16 mg/kg body wt.) and cyclophosphamide (200 mg/kg body wt.). With a median follow-up of 12 months, overall survival for 44 patients grafted with autologous BM is 61%±9%, progression-free survival for patients with sensitive disease is 44%±11%; no patient with resistant relapse survived beyond 1 year post transplant. Two of three patients grafted with allogeneic BM still survive 15 and 24 months after BMT with Karnofsky performance scores of 70% and 100%, respectively. The main toxicity encountered with the CVB regimen was interstitial pneumonia (IP), seen in four of 15 patients (27%) receiving ≥600 mg/m2 of BCNU. Three of these patients have died. The results show that HDT followed by hematopoietic stem cell rescue may effectively salvage an important fraction of patients with relapsed HD who respond to standard chemotherapy. The same approach is largely unsuccessful in patients with proven refractoriness to standard chemotherapy. Whether HDT followed by BMT or PBSC support is superior to intensive chemotherapy without stem cell support can be answered only by a prospectively randomized trial.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01738475
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  • 4
    Digitale Medien
    Digitale Medien
    Transplant activities in Germany in 1998 – a survey facilitated by the National Registry for Hemopoietic Stem Cell Transplantation (2000)
    Springer
    Annals of hematology 79 (2000), S. 437-443 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Blood stem cell transplantation ; Data management quality control
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  To improve the infrastructure of hemopoietic stem-cell transplantations in our country, the German Registry for Hemopoietic Stem-Cell Transplantations (DRST) was established in 1998. The present paper summarizes the current status of the DRST and gives a survey of transplant activities in Germany in 1998 in terms of transplant units, transplant types, transplant frequencies and underlying diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002770000194
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  • 5
    Digitale Medien
    Digitale Medien
    Prognostic factors in COPP-treated patients with Hodgkin's disease (1982)
    Springer
    Annals of hematology 44 (1982), S. 339-348 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Hodgkin's disease ; Risk factors ; Staging system ; Chemotherapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a recently published review of the literature [40] we came to the conclusion that the Ann-Arbor staging classification is of limited prognostic value for chemotherapy of Hodgkin's disease (Table 2). Four risk factors accounted for impaired complete remission rates: stage IVB, lymphocyte depletion or not classifiable histologic type, previous chemotherapy, and older age. Fifty-eight evaluable patients were treated with COPP; 23 reached a complete remission (40%). Disease-free survival was 31%, overall survival 49% after five years [33]. Besides the known risk factors, impaired bone marrow function (leucocyte counts 〈4×109/1, platelet counts 〈100×109/1) at the start of therapy was associated with poor treatment results: none of six patients achieved a complete remission [41]. Eleven of 16 patients with no and 11 of 23 patients with one risk factor achieved a complete remission, as did only one patient with more than one risk factor. Survival rates after 30 months were; 87% with no, 66% with one, 36% with two, and 13% with more than two risk factors. We can conclude from our results that the prognosis of patients undergoing chemotherapy for Hodgkin's disease depends on the number of risk factors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00319917
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  • 6
    Digitale Medien
    Digitale Medien
    Sequential high-dose therapy and autologous stem cell transplantation for treatment of mantle cell lymphoma (1997)
    Springer
    Annals of oncology 8 (1997), S. 401-403 
    Details
    ISSN: 1569-8041
    Schlagwort(e): Mantle cell lymphonia ; pbpc ; therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background: Mantle cell lymphoma (MC) is not curable with conventionalchemotherapy. To improve the prognosis of patients with this disease, weprospectively studied an intensive sequential therapy consisting of theDexa-BEAM regimen (dexamethasone, BCNU, etoposide, ara-C, melphalan) followedby myeloablative therapy with autologous stem cell reinfusion. Patients and methods: Nine consecutive patients with stage III/IV MC wereincluded. Two had untreated disease, four were in first remission, whereasthree had more advanced disease. All patients underwent one to two cycles ofDexa-BEAM chemotherapy to reduce the tumor load and to mobilize peripheralblood progenitor cells (PBPC). Subsequently, patients were treated withhigh-dose radiochemotherapy followed by PBPC reinfusion and were prospectivelyanalyzed for residual disease by clinical methods as well as by PCRamplification clonal CDRIII rearrangements. Results: With an overall response rate of 100%, the initialDexa-BEAM cycles effectively reduced the tumor load. All patients proceededto high-dose therapy and subsequent stem cell rescue. Engraftment was prompt,and procedure-related deaths did not occur. With a median follow-up of 12(3–33) months post transplant, all patients are alive in continuingclinical and molecular remission. Conclusions: Sequential intensive therapy consisting of Dexa-BEAM andhigh-dose radiochemotherapy appears to be a highly effective treatment forpatients with MC. However, the data are still preliminary, and larger patientnumbers and a longer follow-up are required.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008251301319
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