ISSN:
1612-1112
Keywords:
Chromatography, general
;
Optimization
;
Information theory
;
Kalman filter
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The influence of variables Z (mobile phase composition X, column length L, etc.) on chromatographic analysis is studied in terms of the two separate stages of the whole optimization process. In the first stage, peak separation is the central concern and the resolution Rs can be related to Shannon information φj of peak $$j:\frac{{\partial \phi _j }}{{\partial Z}} = C\frac{{\partial R_s }}{{\partial Z}}$$ where C is a coefficient (〉0). In the second stage, only chromatograms with no peak overlap are considered and Rs is not connected with φj. The analytical role of Z is evaluated by comparing the signs and magnitudes of the derivatives of the information, φj, and its transmission rate, ϑj, with respect to Z in both stages.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02262195
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