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  • Key words: Vøring margin, Ocean-Bottom Seismograph, crustal structure, volcanic continental margin.  (1)
  • UFT  (1)
  • Vascular anatomy  (1)
  • compliance  (1)
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  • 1
    ISSN: 1420-9136
    Keywords: Key words: Vøring margin, Ocean-Bottom Seismograph, crustal structure, volcanic continental margin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —This paper presents a crustal model derived from an Ocean Bottom Seismograph (OBS) study along the northern Vøring margin off Norway. The profile was acquired to map the crustal structure in the northernmost part of the Vøring Basin, and to link crustal models of the Lofoten and central Vøring Basin obtained by previous OBS studies. The Vøring margin, as well as the Lofoten margin to the north, was created by continental breakup between Norway and Greenland in late Paleocene-early Eocene. The rifting and continental breakup process were accompanied by intense extrusive and intrusive magmatic activities. The OBS data provide the whole crustal structure along the northern Vøring margin, in the area where the deep crustal structure cannot be resolved by conventional multichannel reflection data due to sill intrusions in the sedimentary sequence. The shallow part of the crustal model is characterized by up to 10 km thick sediments, a sequence of flood basalts and sill intrusions. The P-wave velocities in the flood basalts and sill intrusions are estimated to 5.0 km/s and 4.7–5.8 km/s, respectively. The model indicates an abrupt thickening of the upper crystalline crust from approx.3 km in the NE, to about 10 km towards the SE, with velocities of 6.0–6.2 km/s. The lower crustal velocities are not well resolved due to lack of clear refraction arrivals from the lower crust. However, the observed amplitude versus offsets are best explained by a model with a change in lower crustal velocities from 6.8 to 7.2 km/s beneath the Bivrost lineament. The modelling infers the presence of a lower crustal reflector beneath the lineament, which represents the landward continuation of the Bivrost lineament. Reflection arrivals from the Moho reveal a Moho depth of 23 km in the middle of the profile and 18– 20 km in the northeastern part of the profile. A 370 km long crustal section from the central part of the Vøring Basin to the Lofoten margin, obtained by the results of this study and previous OBS studies, shows a simple thinned continental crust on the Lofoten margin, and a high velocity lower crust underlying an upper crust of varying thickness in the Vøring Basin. The transition between these structures is situated beneath the Bivrost lineament in the lower crust, and beneath the basement high about 40 km south of the lineament in the upper crust.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1041
    Keywords: Key words 5-Fluorouracil ; Hair analysis; adjuvant chemotherapy ; oral administration ; compliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract.  Objective: Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and its potential usefulness is discussed as an index of compliance with postoperative adjuvant chemotherapy. Methods: Hair samples obtained from 55 patients, who had received oral 5-FU (total dose 27-41 g) as postoperative adjuvant chemotherapy over a 6-month period, were used for the analysis of 5-FU. The drug was extracted from the hair using ethyl acetate, and its fluorescence derivatization was employed for measurement with HPLC. The detection limit of 5-FU in hair was 0.01 ppm. Results: In 22 out of 55 samples 5-FU content was under the detection limit, whereas in the remaining 33 samples the drug was detected in a range of 0.006-2.125 ng per hair strand; in addition, drug content showed a log-normal distribution. 5-FU was detected in the hair collected from those patients who were possibly compliant with the postoperative oral adjuvant chemotherapy. Conclusion: As many as 40% of the patients analysed were supposed to be much less compliant. Even in the possibly compliant patients, the degree of compliance with the therapy varied according to a log-normal distribution.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 22 (2000), S. 21-24 
    ISSN: 1279-8517
    Keywords: Vascular anatomy ; Muscle flap ; Graciloplasty ; Anal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dynamic graciloplasty has recently been developed for reconstruction of anal function in patients who are fecally incontinent in preference to permanent abdominal colostomy. Since the muscular portion of gracilis is wrapped around the neoanus, the length of the gracilis arc influences the functional outcome of graciloplasty. Although dissection of the main pedicle (i.e. the main artery and vein) can facilitate gracilis to have enough muscle arc, it has been unclear whether there are any vessels proximal to the main pedicle or through the origin of the muscle which could support blood flow into the whole of gracilis. In this study, the vascular anatomy of gracilis in both legs of 26 Japanese cadavers was examined. All muscles had a main pedicle, mean maximum diameter 1.08 mm, entering at the proximal one-third of the muscle. However, only 18 muscles (34.6%) had an accessory artery in the proximal portion in addition to the main pedicle. Some arteries always exist at the origin of the muscle, having a mean maximum diameter of 0.34 mm, suggesting that they might be able to support the whole gracilis without supply from the main pedicle.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1437-7772
    Keywords: Rectal cancer ; Adjuvant chemotherapy ; Disease-free survival ; Mitomycin C ; UFT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. This study was conducted to evaluate the significance of postoperative adjuvant chemotherapy using mitomycin C (MMC) and UFT (tegafur; uracil at 1:4 molar ratio) in combination for rectal cancer. Methods. The Japanese Foundation for Multidisciplinary Treatment of Cancer conducted a prospective randomized controlled trial in 834 patients who had undergone curative resection for rectal cancer (T3 or T4 and/or Nl, N2, or N3 according to TNM classification) from February 1986 to December 1988. The patients were randomly allocated to a treatment group (MMC/UFT, 416 patients) and a control group (surgery alone, 418 patients). For the patients in the treatment group, 20 mg of MMC was sprinkled on the operating field upon completion of surgery. MMC was injected intravenously (6 mg/m2) on day 7, and then once a month for months 1–6 after surgery. UFT was administered at 400mg/day, orally, for 1 year, beginning 3 weeks after surgery. Results. There was no difference, in the 5-year survival rate between the two groups, but the 5-year disease-free survival rate in the MMC/UFT group (68.9%) was significantly higher than that (59.3%) in the control group (P = 0.006). The 5-year cumulative local recurrence rate was significantly lower in the MMC/UFT group (11.6%) than in the control group (19.0%) (P = 0.007). Conclusion. We conclude that the adjuvant use of longterm oral UFT and intermittent MMC (i.v.) improves the disease-free survival rate of patients with curatively resected rectal cancer (T3 or T4 and/or N1, N2, or N3).
    Type of Medium: Electronic Resource
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