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  • 1
    Electronic Resource
    Electronic Resource
    Akute demyelinisierende Enzephalomyelitis eines 10jährigen Mädchens unter dem Bild einer Multiplen Sklerose (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 608-612 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Akute demyelinisierende Enzephalomyelitis ; Multiple Sklerose ; Zerebrale Kernspintomographie ; Neuropathologie ; Key words Acute demyelinating encephalomyelitis ; Multiple sclerosis ; Cerebral MRI ; Neuropathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Multiple sclerosis is a rare disease in childhood. A 10 1/2 year old girl developed a rapidly ongoing paresis of the right leg accompanied by paresthesia, sphincter incompetence and retrobulbar neuritis. Results: Laboratory tests including examination of the cerebrospinal fluid were normal. Magnetic resonance imaging (MRI) of the brain revealed multiple circular lesions with central hypodensities in both hemispheres. A biopsy of the brain was performed. The histological picture showed changes of acute demyelinating encephalomyelitis also visible in early and subacute stages of multiple sclerosis. Discussion: Unusual findings especially of the MRI made it more difficult in this case to find the correct diagnosis.
    Notes: Zusammenfassung Die Multiple Sklerose ist eine seltene Erkrankung im Kindesalter. Bei einem 10jährigen Mädchen entwickelte sich eine rasch fortschreitende Parese des rechten Beins, begleitet von vegetativen und sensiblen neurologischen Ausfällen sowie einer Retrobulbärneuritis. Befund: Die Laboruntersuchungen einschließlich der Liquordiagnostik ergaben unauffällige Befunde. Mit Hilfe der Kernspintomographie waren mehrere, max. 3×3 cm2 große, zentral hypodense Rundherde in beiden Großhirnhemisphären erkennbar. Aus einer Läsion wurde stereotaktisch Hirngewebe entnommen. Histologisch ließen sich Veränderungen nachweisen, die sowohl in einer Frühform als auch im subakuten Stadium einer multiplen Sklerose beobachtet werden. Die klinisch vermutete Diagnose einer akuten demyelinisierenden Enzephalomyelitis wurde damit auch neuropathologisch bestätigt. Diskussion: Die ungewöhnlichen Befunde insbesondere der Kernspintomographie erschwerten in diesem Fall die Diagnosefindung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050301
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  • 2
    Electronic Resource
    Electronic Resource
    Expression of MDR1/p-glycoprotein and multidrug resistance-associated protein in childhood solid tumours (1997)
    Springer
    Virchows Archiv 430 (1997), S. 99-105 
    Details
    ISSN: 1432-2307
    Keywords: Multidrug resistance ; P-glycoprotein Neuroblastoma ; Nephroblastoma ; Reverse transcriptase polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the expression of MDR1/p-glycoprotein in paediatric tumours using reverse transcriptase polymerase chain reaction (RT-PCR), RNA dot blot analysis, and immunohistochemistry on formalin fixed paraffin-embedded material with JSB-1 and C-219 monoclonal antibodies, and compared these three techniques. The expression of multidrug resistance-associated protein (MRP) gene was examined by RT-PCR assay. We studied MDR1/p-glycoprotein and MRP expression in 13 samples from 10 neuroblastoma patients, 11 samples from 10 nephroblastoma patients, 2 rhabdomyosarcomas, 1 adrenocortical carcinoma and 10 benign tumours or tumour-like lesions. Eleven of 13 neuroblastomas, 7 of 11 nephroblastomas, 2 rhabdomyosarcomas, 1 adrenocortical carcinoma, and 7 of 10 benign tumours or tumour-like lesions showed MDR1 PCR products. By RNA dot blot analysis, MDR1 transcripts were detectable in 11 of 34 specimens. Immunohistochemically, we detected positive reaction products for JSB-1 in 26 of 36 samples. There was a significant correlation between the immunoreactivity for JSB-1 and the expression of MDR1 mRNA expression by RTPCR (P=0.0001). However, the presence of p-glycoprotein immunostaining does not correlate with the MDR1 expression shown by RT-PCR in every case. As for MRP mRNA expression, 9 of 13 neuroblastomas and 10 of 11 nephroblastomas revealed PCR products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008030
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    Paper (German National Licenses)
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