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  • 1
    Electronic Resource
    Electronic Resource
    In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 1457-1468 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Dementia ; cholinergic system ; acetylcholine esterase ; positron emission tomography ; cerebral blood flow ; cerebral glucose metabolism.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Memory and attention are cognitive functions that depend heavily on the cholinergic system. Local activity of acetylcholine esterase (AChE) is an indicator of its integrity. Using a recently developed tracer for positron emission tomography (PET), C-11-labeled N-methyl-4-piperidyl-acetate (C-11-MP4A), we measured regional AChE activity in 4 non-demented subjects, 4 patients with dementia of Alzheimer type (DAT) and 1 patient with senile dementia of Lewy body type (SDLT), and compared the findings with measurements of blood flow (CBF) and glucose metabolism (CMRGlc). Initial tracer extraction was closely related to CBF. AChE activity was reduced significantly in all brain regions in demented subjects, whereas reduction of CMRGlc and CBF was more limited to temporo-parietal association areas. AChE activity in SDLT was in the lower range of values in DAT. Our results indicate that, compared to non-demented controls, there is a global reduction of cortical AChE activity in dementia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020070009
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  • 2
    Electronic Resource
    Electronic Resource
    (68Ga)-EDTA positron emission tomography in the diagnosis of brain tumors (1984)
    Springer
    Neuroradiology 26 (1984), S. 393-398 
    Details
    ISSN: 1432-1920
    Keywords: 68Ga scintigraphy ; positron emission tomography ; brain tumors ; tumor tracer uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-two patients with active brain tumors and 8 patients with brain lesions from surgical treatment and/or radio-and/or chemotherapy of their brain tumors were examined by positron emission tomography (PET) using (68Ga)-EDTA in addition to conventional X-ray computed tomography (XCT). All patients with active brain tumors showed abnormal uptake of radioactivity in the tumor region, while all treated patients had normal PET scans. Site and shape of abnormal radioactivity accumulation were in good agreement with the tumor as demonstrated by XCT. Small tumors had a tendency to appear larger in PET than in XCT, while tumors with a mean largest diameter of more than 50.7 mm in XCT usually appeared smaller in PET. Despite considerable overlap to tumor classes with respect to their degree of tracer uptake a highly significant decreasing order of tumor-sagittal sinus ratios of radioactivity (TSR) was found, malignant gliomas ranking highest (median TSR 0.634), followed by meningiomas (median TSR 0.522) and metastases (median TSR 0.391), benign gliomas showing the least uptake (median TSR 0.307). These findings suggest that PET with (68Ga)-EDTA has a high sensitivity supplementing XCT in the diagnosis of brain tumors, and may be helpful in early detection of recurrent tumor growth after therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327493
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Positron emission tomography in degenerative disorders of the dopaminergic system (1992)
    Springer
    Journal of neural transmission 4 (1992), S. 121-130 
    Details
    ISSN: 1435-1463
    Keywords: Dopaminergic system ; glucose metabolism ; positron emission tomography ; Parkinson's disease ; Alzheimer's disease ; progressive supranuclear palsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 21 patients who had Parkinson's disease (PD), PD plus dementia of Alzheimer type (PDAT) or progressive supranuclear palsy (PSP), were studied with positron emission tomography (PET) using (18F)-2-fluoro-2-deoxy-D-glucose (FDG). In one patient with strictly unilateral PD side differences in striatal dopa uptake were studied with 6-(18F)fluoro-L-dopa (F-dopa). In patients with PD PET with FDG did not show any significant change in regional cerebral metabolic rates for glucose (rCMR(Glu)). In PDAT glucose metabolism was generally reduced, the most severe decrease was found in parietal cortex. The metabolic pattern was similar to that typically found in patients with Alzheimer's disease (AD). In the patient with strictly unilateral PD rCMR(Glu) was normal, F-dopa PET, however, revealed a distinct reduction of dopa uptake in the contralateral putamen. In PSP glucose metabolism was significantly decreased in subcortical regions (caudatum, putamen and brainstem) and in frontal cortex. Thus PET demonstrated a clear difference of metabolic pattern between PDAT and PSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02251475
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    Paper (German National Licenses)
    Fulltext
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