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  • 1
    Electronic Resource
    Electronic Resource
    Prognostic value of evoked potentials and clinical grading in primary subarachnoid haemorrhage (1995)
    Springer
    Acta neurochirurgica 137 (1995), S. 146-150 
    Details
    ISSN: 0942-0940
    Keywords: Subarachnoid haemorrhage ; prognosis ; Hunt-Hess grades ; evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective study of 64 patients suffering from primary subarachnoid haemorrhage (SAH), the clinical grading according to Hunt and Hess as well as the initial findings of brainstem auditory evoked potentials (BAEP) and median-nerve somatosensory potentials (SEP) were correlated with each other and with disease outcome to determine the prognostic value of evoked potential testing in comparison to the initial clinical grading according to Hunt and Hess. All patients were treated in a neurological intensive care unit. Normal evoked potentials usually indicate a favourable course. Alterations of SEP and BAEP increase in parallel with the severity of clinical findings. Unilateral or bilateral loss of SEP or BAEP indicates a poor prognosis. Clinical and electrophysiological findings show a close correlation, but only BAEP provide prognostic information beyond Hunt/Hess grading. In SAH patients, clinical grading was well as evoked potentials correlate significantly with outcome. Use of both clinical and EP rating improves prognostic accuracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187186
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  • 2
    Electronic Resource
    Electronic Resource
    Positron emission tomography in neuropsychology
    Amsterdam : Elsevier
    Neuropsychologia 24 (1986), S. 141-149 
    Details
    ISSN: 0028-3932
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0028-3932(86)90048-5
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  • 3
    Electronic Resource
    Electronic Resource
    Positron emission tomography as an imaging tool in psychiatric disorders
    Amsterdam : Elsevier
    Psychiatry Research 29 (1989), S. 351-352 
    Details
    ISSN: 0165-1781
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1781(89)90086-3
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  • 4
    Electronic Resource
    Electronic Resource
    Functional and morphological abnormalities in temporal lobe epilepsy: a comparison of interictal and ictal EEG, CT, MRI, SPECT and PET (1987)
    Springer
    Journal of neurology 234 (1987), S. 377-384 
    Details
    ISSN: 1432-1459
    Keywords: Temporal lobe epilepsy ; Drug-resistant seizures ; EEG video monitoring ; Morphological neuro-imaging ; Functional neuro-imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten patients suffering from drug-resistant complex partial seizures, with EEG abnormalities in the temporal region, were studied by means of non-invasive electrophysiological techniques (video-monitored, 16-channel, prolonged surface and sphenoidal EEG) as well as by imaging techniques (CT, MRI, SPECT and PET). Analysis of interictal and ictal EEG indicated the localization of epileptic activity in one side in eight cases. CT demonstrated focal abnormalities in three, SPECT in five unequivocally (in another four questionably, with the same lateralization as indicated by PET), MRI in eight, and PET in all cases. While only EEG provided specific diagnostic information, the focus definition was consistently good on PET images, poor on CT scans, and generally good but less consistent on MRI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314081
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  • 5
    Electronic Resource
    Electronic Resource
    Regional cerebral blood flow in man at rest and during exercise (1987)
    Springer
    Journal of neurology 234 (1987), S. 9-13 
    Details
    ISSN: 1432-1459
    Keywords: Cerebral blood flow ; 133Xe ; Exercise ; Autoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Regional cerebral blood flow (rCBF) of the left hemisphere was measured in 12 healthy young men at rest and during physical work on a bicycle ergometer in the supine position at work-load levels of 25 W or 100 W using the intravenous 133Xe method. Regional mean cerebral blood flow, regional gray-matter flow, and relative gray-matter weight was determined for six regions of interest. Arterial blood pressure, pulse frequency and expiratory CO2 concentration were recorded. Cerebral blood flow in all regions was significantly (P〈0.001) higher during exercise than at rest. The increase in the 100 W group (24.7%) was significantly (P〈0.05) greater than in the 25 W group (13.5%), but resting blood flow levels and alveolar CO2 concentrations were also different in both groups. Mean arterial blood pressure, pulse frequency and alveolar CO2 concentrations, but not arterial pCO2, were significantly higher during exercise and there was a faster washout of whole-body xenon. The CBF increase was interpreted as a combined effect of elevated systemic blood pressure and functionally activated brain metabolism. There was no evidence of impaired cerebral autoregulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314001
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  • 6
    Electronic Resource
    Electronic Resource
    Changing patterns of glucose metabolism during the course of subacute sclerosing panencephalitis as measured with18FDG-positron-emission tomography (1992)
    Springer
    Journal of neurology 239 (1992), S. 157-161 
    Details
    ISSN: 1432-1459
    Keywords: 18FDG-positron emission tomography ; Subacute sclerosing panencephalitis ; Glucose metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 18FDG-positron emission tomography performed at different stages in the course of subacute sclerosing panencephalitis revealed a changing pattern of metabolic disturbance. In clinical stage II patients the inflammation in the basal ganglia appeared to lead to neuronal excitation accompanied by hypermetabolism. Widespread cortical functional inhibition of metabolism followed. The striatal inflammation ended with necrosis and hypometabolism, with resulting functional cortical disinhibition; later, deep midbrain structures and brain stem became hypermetabolic. A patient clinically in remission showed no such changes in cerebral glucose metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00833917
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  • 7
    Electronic Resource
    Electronic Resource
    (68Ga)-EDTA positron emission tomography in the diagnosis of brain tumors (1984)
    Springer
    Neuroradiology 26 (1984), S. 393-398 
    Details
    ISSN: 1432-1920
    Keywords: 68Ga scintigraphy ; positron emission tomography ; brain tumors ; tumor tracer uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-two patients with active brain tumors and 8 patients with brain lesions from surgical treatment and/or radio-and/or chemotherapy of their brain tumors were examined by positron emission tomography (PET) using (68Ga)-EDTA in addition to conventional X-ray computed tomography (XCT). All patients with active brain tumors showed abnormal uptake of radioactivity in the tumor region, while all treated patients had normal PET scans. Site and shape of abnormal radioactivity accumulation were in good agreement with the tumor as demonstrated by XCT. Small tumors had a tendency to appear larger in PET than in XCT, while tumors with a mean largest diameter of more than 50.7 mm in XCT usually appeared smaller in PET. Despite considerable overlap to tumor classes with respect to their degree of tracer uptake a highly significant decreasing order of tumor-sagittal sinus ratios of radioactivity (TSR) was found, malignant gliomas ranking highest (median TSR 0.634), followed by meningiomas (median TSR 0.522) and metastases (median TSR 0.391), benign gliomas showing the least uptake (median TSR 0.307). These findings suggest that PET with (68Ga)-EDTA has a high sensitivity supplementing XCT in the diagnosis of brain tumors, and may be helpful in early detection of recurrent tumor growth after therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327493
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  • 8
    Electronic Resource
    Electronic Resource
    PET studies of dopamine receptor distribution using [18F]fluoroethylspiperone: findings in disorders related to the dopaminergic system (1990)
    Springer
    Journal of neural transmission 81 (1990), S. 195-213 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine receptors ; positron emission tomography ; [18F]fluoroethylspiperone ; disorders of dopaminergic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary PET studies of dopamine D2-receptor binding were performed in thirty patients with various disorders related to the dopaminergic system and in six healthy controls. Uptake of [18F]fluoroethylspiperone in caudate over three hours was analyzed in terms of several indices of receptor binding: caudateto-cerebellum activity ratio, concentration of ligand as percentage of injected dose, caudate-to-blood radioactivity ratio, slope of tracer uptake curves, binding potential, kinetic constants of a three compartment model. In 14 patients brain glucose metabolism was also measured. Data on medicated patients demonstrate that the average values of most of the above parameters indicate the decreased number of available D2-receptors whereby, besides an age dependent decline, the caudate-to-cerebellum ratio affords the relatively best distinction among diagnostic groups. In individual cases, large variability among subjects permits only the classification of severe pathologies. Morphological damage and neuronal loss in the striatum may also cause abnormal low values both for the indices of receptor binding and for glucose consumption, thus providing a possible pathogenetic link between receptor dysfunction and impaired energy metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245042
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