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  • 11
    Electronic Resource
    Electronic Resource
    Polychlorinated biphenyl residues in maternal and cord blood in Tokyo metropolitan area (1975)
    Springer
    Bulletin of environmental contamination and toxicology 14 (1975), S. 588-592 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary PCB levels were determined with maternal and cord blood sampled at the time of delivery. All of the twentyfour mothers selected for this experiment are residents of Tokyo Metropolitan area. Gaschromatographic patterns of PCBs in cord blood closely resembled those of mothers. The cord blood in general showed lower PCB levels on both whole and fat basis than those in the maternal blood. No correlation was noticeable on statistical basis as regards the concentrations of PCBs between the cord blood and maternal blood. Our data suggests that the passage of PCBs through the placenta follows general patterns observed in other organochlorine insecticides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01683376
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  • 12
    Electronic Resource
    Electronic Resource
    Indomethacin preferentially augments 5-fluorouracil cytotoxicity in Colon 26 tumors by increasing the intracellular inflow of 5-fluorouracil (1999)
    Springer
    International journal of clinical oncology 4 (1999), S. 22-25 
    Details
    ISSN: 1437-7772
    Keywords: Key words Cancer ; Indomethacin ; 5-Fluorouracil (5FUra)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The antitumor effect of indomethacin has been well documented in cancer patients and in animals with transplanted tumors. Indomethacin has also been regarded as a biological response modifier. Therefore, we presumed that indomethacin could be a modulator of antitumor agents, and this study was done to determine whether indomethacin modified the cytotoxicity of selected antitumor agents. Methods. The effect of indomethacin on the antitumor activity of 5-fluorouracil (5FUra), cis-platinum (CDDP), and etoposide in Colon 26 tumor cells was evaluated in vitro by MTT assay. Results. Indomethacin did not show a cytotoxic effect on the tumor cells at pharmacological concentrations. Indomethacin preferentially modulated the cytotoxicity of 5FUra, while it did not affect the cytotoxicity of CDDP and etoposide. Several fold indomethacin (0.01 and 0.1 μg/vol) enhanced 5FUra cytotoxicity in tumor cells. Indomethacin increased the 5FUra content in the tumor cells by 80% over the control through increasing the inflow of 5FUra, rather than by prohibiting the efflux of 5FUra. Conclusion. Indomethacin appears to be a candidate for augmenting 5FUra cytotoxicity in tumor cells by facilitating the intracellular uptake of 5FUra. This study suggests the effectiveness of indomethacin in reducing the dosage of 5FUra or in augmenting 5FUra cytotoxicity when given at the same dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101470050018
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  • 13
    Electronic Resource
    Electronic Resource
    Cryogenic STM/STS observation on oxide superconductors (1994)
    Springer
    Journal of superconductivity 7 (1994), S. 349-353 
    Details
    ISSN: 1572-9605
    Keywords: Scanning tunneling microscopy ; YBa2Cu3Oy ; laser-ablated thin films ; tunneling spectroscopy ; superconducting energy gap
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract The topographic and electronic properties of the surfaces of (001) and (110) oriented YBa2Cu3Oy, epitaxial films have been probed by atomic resolution STM/STS at 4.2 K. The STM image on the (001) surface clearly revealed the atomic corrugation of the tetragonal lattice with an average spacing of 0.4 nm. while on the (110) surface the orthorhombic atomic lattice, corresponding to the Cu atoms of both CuO2 and CuO chain planes, was observed. The STS result on the (001) surface indicated the semiconducting nature of the terminating layer. As the tunneling tip came closer to the surface, however, the shape of the tunneling spectrum became more metallic and showed a superconducting energy gap, which seems to arise from the underlying superconducting layer. On the other hand, the tunneling spectra on the (110) surface indicated superconducting gap structures, independent of the tip-sample distance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00724567
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  • 14
    Electronic Resource
    Electronic Resource
    Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: Roles of complement, bradykinin, and inducible cyclooxygenase-2 (1996)
    Springer
    Inflammation research 45 (1996), S. 335-346 
    Details
    ISSN: 1420-908X
    Keywords: Granulocyte colony-stimulating factor ; Neutrophil migration ; Complement ; Kinin ; Cyclo-oxygenase-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of human recombinant granulocyte colony-stimulating factor (G-CSF, 100 μg/kg/day, s.c) to rats for 4 days significantly increased circulating neutrophil counts (by 1130%), together with an increase in mononuclear leukocyte counts (by 119%). Infiltrated pleural neutrophil counts in G-CSF-treated rats (G-CSF-r) 5h after the intrapleural injection of zymosanactivated serum were significantly higher (by 155%) than those in control rats (Vehicle-r). In carrageenin-induced pleurisy, counts of infiltrated pleural neutrophils in G-CSF-r 5 and 7h after carrageenin were significantly higher (by 119% and 116%) than those in Vehicle-r. G-CSF treatment increased the volume of pleural exudate and the plasma exudation rate by 122% and 226%, compared to values in Vehicle-r 5h after carrageenin. Cobra venom factor (75 μg/kg, i.v.) significantly reduced pleural neutrophil migration in G-CSF-r (by 53%) and Vehicle-r (by 49%). Bromelain (10 mg/kg, i.v.) and aspirin (100 mg/kg, p.o.) reduced pleural neutrophil migration and reduced exudate volume and plasma exudation. Intrapleural bradykinin-(1–5) and prostaglandin E2 levels were significantly higher in G-CSF-r than in Vehicle-r. The increased neutrophil migration in G-CSF-r may be atributed to enhanced activation of the complement system facilitated by increased plasma exudation due to bradykinin and prostaglandins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02252946
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  • 15
    Electronic Resource
    Electronic Resource
    Determination of bradykinin-(1–5) in inflammatory exudate by a new ELISA as a reliable indicator of bradykinin generation (1996)
    Springer
    Inflammation research 45 (1996), S. 416-423 
    Details
    ISSN: 1420-908X
    Keywords: Enzyme-linked immunosorbent assay (ELISA) ; Bradykinin-(1–5) ; Carageenin-induced pleurisy ; Nasal allergy ; Kinin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have developed an ELISA for BK-(1–5) (Arg1-Pro2-Pro3-Gly4-Phe5). In rat carrageenin-induced pleurisy, in which a plasma exudation peak was observed 5 h after carrageenin, BK levels in the exudates were negligible (〈60 pg/rat). BK-(1–7) (des-Phe8-Arg9-BK) was detectable (900–400 pg/rat) over the entire course of the inflammation. However, a larger amount of BK-(1–5) was detectable in association with the increase in plasma exudation, showing a peak (8800±1200 pg/rat) 3 h after carrageenin. Bromelain (10 mg/kg, i.v.) and soy bean trypsin inhibitor (0.3 mg/rat, intra-pleural) significantly reduced BK-(1–5) levels (by 60–93%, 3, 7 and 19 h after carrageenin) and plasma exudation rates (by 61–74%, 3 and 7 h after carrageenin). Dexamethasone (0.3 mg/kg, i.p.) reduced BK-(1–5) levels (by 78%) and decreased plasma exudation (by 70%) 3 h after carrageenin. In nasal allergy patients, antigen challenge of nasal mucosa elevated BK-(1–5) levels and active kallikrein levels in nasal washes. These results verify that BK-(1–5) determined by ELISA is a good indicator for release of kinins in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02252938
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  • 16
    Electronic Resource
    Electronic Resource
    Zirconia Knee Wear and Raman Spectroscopy Studies Compares 3.5-Mrad and 7-Mrad UHMWPE Inserts (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 309-311 (May 2006), p. 1285-1288 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: We studied the long-term wear behaviour of alumina-doped zirconia femoral condyles against ultra-high molecular weight polyethylene (UHMWPE) tibial inserts. The simulator kinematics included 20 degrees of flexion/extension, ± 5 degrees of internal/external rotation, and 6 mm of anterior/posteriortranslation. All knee components were subjected to 10 million cycles of normal walking (2.6 KN max, freq. 1.8 Hz). Lubricant was 50% alpha-calf serum (20 mg/ml protein) with EDTA. The tibial inserts were from one lot of ram-extruded UHMWPE and sterilized with 3.5-Mrad or 7-Mrad radiation dose. Soak controlswere stored unloaded in deionised water for 60 days prior to testing. Implants were studied with high-resolution confocal Raman spectroscopy after 10-Mc duration. The wear of control knees (CoCr/3.5-Mrad) averaged 4.5mm3/Mc while the wear with the ZrO2/7-Mrad combination was unmeasurably low even after 10 million cycle duration. Raman Spectroscopy at 10-Mc duration showed only the presence of the desired tetragonal phase. Thus, the ZrO2/7-Mrad bearing combination shouldprove excellent for active patients who may otherwise risk high wear rates over many years of use
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.1285.pdf
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  • 17
    Electronic Resource
    Electronic Resource
    N-acetylgalactosamine (GalNAc)-specific lectins mediate enhancement of Hantaan virus infection (1999)
    Springer
    Archives of virology 144 (1999), S. 1765-1777 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  N-acetylgalactosamine (GalNAc)-specific lectins, Dolichos biflorus agglutinin (DBA), and soybean agglutinin (SBA), enhanced Hantaan (HTN) virus infections in Vero E6 and P388D1 cells. Treatment of Vero E6 cells with the lectins either before or during, but not after, virus inoculation resulted in lectin-mediated enhancement of infection (LME), indicating that GalNAc-specific lectin affects an early stage of the infection. Lectin blot and FACS analysis showed that the ability of HTN virus envelope glycoproteins and cell surface molecules to bind DBA and SBA was essential for LME. GalNAc clearly inhibited LME, indicating that the lectins bind with their specific carbohydrate-binding site. These results suggest that a lectin cross-link between the virus and the cell surface is the most plausible mechanism for inducing infection enhancement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050703
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  • 18
    Electronic Resource
    Electronic Resource
    STM tunneling spectroscopy on high Tc superconductors (1995)
    Springer
    Journal of superconductivity 8 (1995), S. 467-470 
    Details
    ISSN: 1572-9605
    Keywords: STM ; superconducting gap ; symmetry of order parameter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract STM tunneling spectroscopy has been performed on the bulk single crystals of BiSrCaCuO (BSCCO) and the epitaxial thin films of YBaCuO (YBCO) at cryogenic temperatures. The STM images and tunneling spectra observed on the (001) surfaces can be classified into three cases; 1) Atomic image is visible. However, the tunneling spectrum shows semiconducting or smeared superconducting gap structures, depending on the tip-sample distance. 2) Clear atomic image can not be obtained. But, the tunneling spectrum shows flat bottom region with quite low zero bias conductance. 3) Tunneling spectra demonstrate gapless behavior, independent of the tip-sample separation. These observations support the quasi-2D electronic picture in whichs-wave like 2D superconducting layers are coupled with each other through the Josephson effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00722832
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  • 19
    Electronic Resource
    Electronic Resource
    Thin hydroxyapatite layers formed on porous titanium using electrochemical and hydrothermal reaction (1996)
    Springer
    Journal of materials science 31 (1996), S. 6279-6284 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In our previous study, it was found that hydroxyapatite (HA) microcrystals were precipitated by hydrothermal treatment on an anodic titanium oxide film containing calcium and phosphorus (AOFCP) with an equivalent Ca/P ratio to HA, which was formed on a titanium metal anode in an aqueous electrolytic solution of dissolved calcium acetate and β-glycerophosphate. In this study, the formation mechanism of the AOFCP has been clarified. Spark discharges, which occur on titanium surface with a large amount of heat generation, cause crystallization of the TiO2 matrix of the AOFCP and incorporation of calcium and phosphorus into the matrix from these electrolytes simultaneously. The calcium and phosphorus in the matrix seem to exist as ions rather than as calcium phosphate. Also, thin HA layers consisting of the many precipitated microcrystals can be uniformly formed even on titanium with complex shapes or surface geometries such as the mesh, roughened surfaces and bead-coated porous coating by the present method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00354450
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  • 20
    Electronic Resource
    Electronic Resource
    Hydrothermal precipitation of hydroxyapatite on anodic titanium oxide films containing Ca and P (1999)
    Springer
    Journal of materials science 34 (1999), S. 5893-5898 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Highly-crystallized hydroxyapatite (HA) can be precipitated during heat treatment in high-pressure steam at 300 °C on an anodic titanium oxide film containing Ca and P (AOFCP), which has been electrochemically formed on a titanium substrate prior to the hydrothermal treatment. Factors affecting the precipitation, such as a percentage of distilled water in the autoclave and additives in the AOFCP, were evaluated by scanning electron microscopy. Ca2+ and PO3− 4 ions were leached from the AOFCP into a water layer covering the film surface, and nucleate HA heterogeneously on the porous TiO2 matrix of the AOFCP which was made by the ion leaching. The morphology of the precipitated crystals was significantly affected by the water volume ratio because the concentrations of the Ca2+ and PO4 3− ions varied depending on the thickness of the water layer. The amount of the precipitation decreased on the AOFCP which was formed in the solution containing a small amount of Mg2+ ions or formed on Ti-6Al-4V alloy instead of titanium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004739108534
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