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  • 1
    Electronic Resource
    Electronic Resource
    Morphological and chemical characterization of a starch granule-like polyglucosan deposit isolated from human brain (1981)
    Springer
    Acta neuropathologica 55 (1981), S. 47-52 
    Details
    ISSN: 1432-0533
    Keywords: Non-congophilic granules ; Neuritic plaques ; Corpora amylacea ; Polyglucosan deposits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brightly birefringent granular profiles were revealed by examination of samples of fractionated human cerebral cortex in the polarizing microscope. These profiles resemble a plant starch granule in the light microscope and appear to be pure polysaccharide by chemical and histochemical analysis. Localization of this profile in routine 5 μm tissue sections was difficult because the hardness of the granule allows it to be easily displaced by the microtome knife. This fact might easily lead an investigator to believe these granules are artifactual, thus probably accounting for the lack of information about this interesting profile.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691530
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 113-124 
    Details
    ISSN: 1432-0533
    Keywords: Amyloid ; Alzheimers disease ; Scrapie ; EM ; Isolation ; Gerstmann-Sträussler syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The structure of partially purified, CNS amyloid fibrils from three different sources have been compared by negative stain EM. The fibrils isolated from brains with senile dementia of Alzheimer type were 4–8 nm in diameter, narrowing every 30–40 nm and apparently composed of two 2–4 nm filaments. The fibrils from a Gerstmann-Sträussler syndrome brain were 7–9 nm in diameter, narrowing every 70–80 nm and with a suggestion that they are composed of two 3–5 nm filaments. The fibrils isolated from 87V scrapie-affected mouse brains were 4–8 nm in diameter with a twist every 15–25 nm presumably composed of two 2–4 nm filaments. The fibrils from the scrapie brains were usually observed in pairs. The shape of the clusters of the isolated amyloid fibrils observed in each disease was similar in negative stain and thin section EM preparations and was related to the characteristic morphology of the amyloid fibrils in the neuritic and amyloid plaques in situ. The structural differences between the CNS amyloid fibrils from the various diseases studied by us may reflect differences in the polypeptides which comprise the fibril and/or a different pathogenesis in the formation of the amyloid fibrils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685355
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  • 3
    Electronic Resource
    Electronic Resource
    The comparative immunoreactivities of brain amyloids in Alzheimer's disease and scrapie (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 313-323 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer amyloids ; Synthetic peptide ; Antibodies ; Fibril formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An antibody was raised to a synthetic peptide corresponding to a published sequence for the first 24 residues of a cerebrovascular amyloid peptide (CVAP). Immunohistochemical staining of tissue sections revealed that the antibody bound extensively to cerebrovascular amyloid in Alzheimer disease (AD/SDAT) and Down's syndrome cases. The antibody bound less extensively to neuritic plaques (primitive and mature) and indetectably to neurofibrillary tangles. The antibody did not label scrapie plaques, scrapie-associated fibrils, or Gerstmann-Sträussler syndrome plaques. Immunoblotting experiments showed that the cerebrovascular amyloid peptide epitopes contaminating the neurofibrillary tangle preparations could be extracted with urea, leaving the neurofibrillary tangles intact. These data confirm that the cerebrovascular amyloid peptide is a component of cerebrovascular amyloid, and suggest that its epitopes are also components of neuritic plaque amyloid. The reduced level of immunostaining on amyloid cores in tissue sections suggests that either the cerebrovascular amyloid peptide epitopes are a minor component of amyloid cores, or that their mode of packing or state of processing in amyloid cores renders them relatively inaccessible to the antibody. We also conclude that the cerebrovascular amyloid peptide is not a component of neurofibrillary tangles. The synthetic cerebrovascular amyloid peptide possesses amyloid-like properties: at neutral pH it forms insoluble aggregates consisting of 5–7-nm fibrils, which form red-green birefringent adducts with Congo red and fluoresce with thioflavine S.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687207
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  • 4
    Electronic Resource
    Electronic Resource
    Osteoid osteoma of the petrous bone (1997)
    Springer
    Neuroradiology 39 (1997), S. 821-823 
    Details
    ISSN: 1432-1920
    Keywords: Key words Osteoid osteoma ; Temporal bone ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a case of osteoid osteoma of the petrous bone presenting with progressive sensorineural hearing loss. CT showed a dense homogeneous mass at the promontory surrounded by a thin bony border. On MRI this lesion gave intermediate signal intensity on T1- and T2-weighted spin-echo images and enhanced intensely with gadolinium. Surgical removal and pathological study proved the diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050514
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  • 5
    Electronic Resource
    Electronic Resource
    Mastoiditis, meningitis and venous sinus thrombosis caused by Fusobacterium necrophorum (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 339-341 
    Details
    ISSN: 1432-1076
    Keywords: Key words:Fusobacterium necrophorum– Anaerobic meningitis – Mastoiditis – Venous sinus thrombosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The authors report a case of septic venous sinus thrombosis (VST) and meningitis occurring as an early complication of mastoiditis caused by Fusobacterium necrophorum. CT scan was normal, and cerebral angiography was required to diagnose the VST. The evolution was favourable with appropriate antimicrobial therapy and steroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01956414
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Magnetic resonance investigations of non-acoustic petrous lesions (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 265-268 
    Details
    ISSN: 1434-4726
    Keywords: Petrous bone ; Magnetic resonance imaging ; Gadolinium ; Cholesteatoma ; Temporal bone neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty cases of intrapetrous lesions were studied by a 1.5 T magnetic resonance (MR) unit. In all cases, comparisons were made between MR, CT and clinical findings. Our present material included 9 cholesteatomas, 1 cholesterol cyst, 3 primary epidermoid carcinomas, 2 metastatic neoplasms, 1 glomus jugulare tumor and 4 facial neurinomas. Gadolinium was injected in 7 cases and seemed to be the best method for studying the intrapetrous tumors. MR permitted accurate topographic study and assessment of tumoral extension, as well as a ready demonstration of tumor vascularity. The present findings also showed that MR is not capable of defining small bony detail or calcifications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463570
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  • 7
    Electronic Resource
    Electronic Resource
    Surgical treatment of laryngotracheal stenosis in infants and children (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 341-344 
    Details
    ISSN: 1434-4726
    Keywords: Children ; Larynx ; Trachea ; Stenosis ; Laryngotracheoplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Laryngotracheal stenosis in children is difficult to manage, especially in cases of acquired lesions. Of 317 cases reviewed, 75 surgical cases are reported here: 28 were congenital and 47 acquired, mostly due to endotracheal intubation. A large variety of laryngotracheoplasty techniques have been used in reconstruction, depending on the age and status of the patient, the size of the laryngeal lumen, the exact site of the stenosis and any associated anomalies. The three main techniques used have been described by Evans, Cotton, and Rethi, Stenting relied on Silastic rolls, Montgomery T-tubes and Aboulker Teflon prostheses. The results in 65 patients showed a decannulation rate of 92% in cases of congenital stenosis and 80% in acquired ones. Improvements in therapy still seem necessary in order to reduce the cannulation time following treatment and the sequelae producing dysphonia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463590
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    Paper (German National Licenses)
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