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  • 1
    Electronic Resource
    Electronic Resource
    Tumor-Infiltrating Lymphocytes in Patients with Renal-Cell Carcinoma (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 532 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb36356.x
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  • 2
    Electronic Resource
    Electronic Resource
    Features. Desalination-Power Plant Proves Economically Feasible (1968)
    s.l. : American Chemical Society
    Environmental science & technology 2 (1968), S. 428-434 
    Details
    ISSN: 1520-5851
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/es60018a600
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  • 3
    Electronic Resource
    Electronic Resource
    Splenic T-killer cells can be generated by allogeneic thymic cells in conjunction with assisting factor (1977)
    [s.l.] : Nature Publishing Group
    Nature 267 (1977), S. 353-354 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To illustrate the simplicity by which killer cells may be generated using this method, C57BL/6 spleen cells (107) were co-cultured, for sensitisation purposes, with allogeneic stimulator cells (107, CBA/H X-irradiated with 2,000 rad) derived from spleen and thymus. Supernatant fluids were added to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/267353a0
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of different ribozymes for efficient and specific cleavage of BCR/ABL related mRNAs
    Amsterdam : Elsevier
    FEBS Letters 338 (1994), S. 175-178 
    Details
    ISSN: 0014-5793
    Keywords: BCR/ABL ; Chronic myelogenous leukemia ; Ribozyme
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)80359-5
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  • 5
    Electronic Resource
    Electronic Resource
    High-dose chemotherapy and autologous hematopoieticstem cell transplantation in patients with second primary malignancies (1997)
    Springer
    Hematology and cell therapy 39 (1997), S. 79-83 
    Details
    ISSN: 1279-8509
    Keywords: Autologous bone marrow transplantation ; Autologous peripheral blood stem cell transplantation ; High-dose chemotherapy ; Second primary neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We treated 500 patients with high-dose chemotherapy and autologous bone marrow or autologous peripheral blood stem cell transplantation. Treated conditions included leukemia, lymphoma, breast cancer, lung cancer, germ-cell carcinoma, and other solid tumors. 10/500 (2%) of patients were treated for a second malignancy diagnosed 12 months to 25 years after their initial neoplasm. Four of these ten patients are in complete remission (CR) of both malignancies at a median follow-up of 29+ months after high-dose chemotherapy and autotransplantation. None of these patients would have been eligible for high-dose chemotherapy and autotransplantation by conventional selection criteria which usually exclude patients with a history of prior malignancies. Conclusion. Conventional exclusion criteria for high-dose chemotherapy and autotransplantation may not adequately reflect the prognosis of patients with second or secondary malignancies treated with this therapeutic modality. High-dose chemotherapy and autologous hematopoietic stem cell transplantation may be of true benfit in selected cases of secondary malignancies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00282-997-0079-3
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  • 6
    Electronic Resource
    Electronic Resource
    Bone marrow scintigraphy using Technetium-99m antigranulocyte antibody in malignant lymphomas (1999)
    Springer
    Annals of oncology 10 (1999), S. 79-85 
    Details
    ISSN: 1569-8041
    Keywords: bone marrow scintigraphy ; immunoscintigraphy ; malignant lymphoma ; Tc-99m labelled anti-NCA-95
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The purpose of this study was to elucidate the clinical reliability of immunoscintigraphy (IS) to detect infiltration of the bone marrow in patients with malignant lymphoma. Patients and methods: Whole body IS was performed in 103 patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL) using Tc-99m labelled anti-NCA-95 which allows visualization of the granulopoietic bone marrow. Of these, 52% were studied prior to any therapy. Findings were compared to posterior iliac crest biopsy as well as MRI and/or follow-up examination. Criteria of marrow infiltration were a positive biopsy, positive follow-up, or positive results of MRI. Results: Comparison of IS and biopsy revealed concordant findings in 69 and discordant findings in 34 of 103 patients. Of the 34 patients with discordant results, IS showed lesions suspicious of bone marrow infiltration in 29 patients despite normal biopsy findings. When follow-up and additional examinations were taken into consideration, 10 patients remained with probably false positive and five with false negative IS findings. IS proved to be highly sensitive and specific in patients with HD (100% and 84%, respectively) and high-grade NHL (93% and 84%, respectively). Moderate sensitivity (60%) was found in low-grade NHL. This was possibly due to false negative IS in three to five patients with chemotherapy in contrast to one of five false negative results in patients without chemotherapy. Conclusion: Bone marrow scintigraphy using antigranulocyte antibodies is highly sensitive in HD and high-grade NHL. Positive findings in IS subsequent to a negative biopsy should be followed by guided re-biopsy or MRI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008356910239
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  • 7
    Electronic Resource
    Electronic Resource
    Umschriebene Hyperhidrose im 1. Thorakaldermatom als Ausdruck einer Sympathicusschädigung (1958)
    Springer
    Archives of dermatological research 205 (1958), S. 530-540 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei zwei Patienten (einer davon wurde bereits früher von uns beschrieben und jetzt nachuntersucht) konnten wir folgendes Syndrom beobachten: Im Alter von 14 bzw. 17 Jahren trat erstmalig im Dermatom D 1 eine sehr lästige, umschriebene Hyperhidrose auf, die durch körperliche Anstrengungen, Wärme und Emotionen auslösbar ist, jedoch nicht durch Geschmacksreize. Auf der Seite der Hyperhidrose besteht ein Horner-Syndrom als Hinweis auf eine Sympathicusschädigung, für welche die bei beiden Patienten vorhandenen Halsrippen verantwortlich sein können. Ob darüberhinaus besondere Verlaufseigentümlichkeiten der sympathischen Fasern vorliegen, wird erwogen. Fragen der somatotopischen Gliederung des Sympathicus sowie einer evtl. antagonistischen Innervation der Schweißdrüsen werden erörtert; möglicherweise kommt es durch partielle Lähmung des Sympathicus zur Enthemmung des Parasympathicus im betroffenen Areal. Vielleicht handelt es sich bei der beobachteten Trias (Hyperhidrose im Dermatom D 1, Horner, Halsrippen) um eine konstante Symptomengruppierung, die nicht allzu selten ist und die vor allem vom Dermatologen hin und wieder beobachtet werden kann, da derartige Patienten wahrscheinlich gerade seine Sprechstunde aufsuchen werden. — Durch Röntgentiefenbestrahlung des Halssympathicus wurde bei beiden Patienten die Hyperhidrose für einige Zeit zum Verschwinden gebracht und im ganzen auf ein erträgliches Maß vermindert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00482771
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  • 8
    Electronic Resource
    Electronic Resource
    Responses to T cell receptor/CD3 and interleukin-2 receptor stimulation are altered in T cells from B cell non-Hodgkin’s lymphomas (1995)
    Springer
    Cancer immunology immunotherapy 41 (1995), S. 175-184 
    Details
    ISSN: 1432-0851
    Keywords: Key words TCR/CD3 ; Lymphocytes ; Cytokines ; Lymphomas ; Signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  T cells infiltrating (T-TIL) B cell non-Hodgkin’s lymphomas (NHL) are thought to represent a local host response to the tumor. However, tumor progression in the presence of this T cell infiltrate suggests that the T-TIL may be functionally impaired. To address this issue we determined whether response to stimulation of T-TIL from 25 patients with NHL through the T cell receptor (TCR/CD3) and the interleukin-2 (IL-2) receptor (IL-2R) was intact, since activation of these receptors is important for proliferation and cytokine production. Our results demonstrate defects in response to stimulation via TCR/CD3 and the IL-2R in T-TIL cells from patients with NHL that were not observed with T cells from the peripheral blood. T-TIL showed minimal proliferation to anti-CD3 and only modest proliferation to IL-2 alone or when combined with anti-CD3. Moreover, cytokine production in T-TIL was impaired since stimulation through the TCR/CD3 complex did not induce mRNA for interferon γ (IFNγ), IL-2, IL-4 or IL-10. The functional unresponsiveness of these cells may be linked to altered signalling through the TCR/CD3 since an abnormal tyrosine phosphorylation pattern was detected in T-TIL after stimulation with anti-CD3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01521344
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  • 9
    Electronic Resource
    Electronic Resource
    Cyclophosphamide-induced hemorrhagic cystitis. An interdisciplinary problem (1998)
    Springer
    Der Urologe 37 (1998), S. 516-521 
    Details
    ISSN: 1433-0563
    Keywords: Key words Hemorrhagic cystitis • Chemotherapy • ; Cyclophosphamide-treatment ; Schlüsselwörter Hämorrhagische Zystitis • Chemotherapie • Cyclophosphamidtherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die hämorrhagische Urozystitis als Folge der Urotoxizität von Cyclophosphamid ist eine bekannte und nicht selten lebensbedrohliche Komplikation der Hochdosischemotherapie. Sie wird gehäuft nach allogener Knochenmarktransplantation beobachtet. Die hämorrhagisch-ulzerösen Veränderungen des Blasenurothels gehen ohne Prophylaxe mit Mikro-/Makrohämaturie, Koagelbildung und meist schwer stillbarer Blutung in bis zu 70 % der Patienten einher. Durch prophylaktische Maßnahmen läßt sich die Inzidenz reduzieren, jedoch nicht zuverlässig verhindern. Therapeutisch sind die meisten Fälle mit forcierter Diurese oder Dauerspülung der Blase unter Kontrolle zu bringen. Bei persistierender Blutung ist nach einem Stufenplan vorzugehen, der zunächst endoskopische Eingriffe und danach den Einsatz hämostyptischer Instillate vorsieht. Invasive Verfahren, wie Embolisation oder offen chirurgische Intervention bilden die Ausnahme, sind unter vitaler Indikation jedoch zu erwägen.
    Notes: Summary Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide. The incidence is particularly high after allogeneic bone marrow transplantation. The morphologic bladder wall changes are associated with gross hematuria, clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures. Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis. Treatment is initiated by forced diuresis and continous bladder irrigation. When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents. Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050211
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  • 10
    Electronic Resource
    Electronic Resource
    Apparent decrease and elimination of BCR/ABL mRNA-expressing residual cells in patients with chronic myelogenous leukemia after allogeneic bone marrow transplantation (1991)
    Springer
    Annals of hematology 63 (1991), S. 189-194 
    Details
    ISSN: 1432-0584
    Keywords: Chronic myelogenous leukemia ; Allogeneic bone marrow transplantation ; Minimal residual disease ; BCR/ABL mRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A modified two-step polymerase chain reaction (PCR) was used for the amplification of BCR/ABL mRNA in 16 patients with Philadelphia chromosomepositive (Ph+) chronic myelogenous leukemia (CML) following allogeneic bone marrow transplantation (BMT). At different intervals after BMT, patient cells were assessed for the presence of BCR/ABL mRNA by two subsequent rounds of PCR amplification; this procedure increased the sensitivity for the detection of one Ph+ cell in 104–5 to one cell in 105–6. Eight of 16 patients were negative by two-step PCR 1–39 months after BMT, suggesting an elimination of Ph-positive cells or a decrease below the threshold of detection. Although five patients showed negative results by the one-step PCR only, they were tested positive when nested primers were used, indicating a substantial decrease in the amount of BCR/ABL target mRNA compared with earlier pre- or post-transplant analyses. One patient who was still PCR positive 27 months after BMT became negative 12 months later. Persistence of BCR/ABL mRNA-expressing cells correlated with subsequent clinical relapse only when the transplantation was performed during blast crisis. All patients who underwent transplantation in chronic phase, including those with BCR rearrangement by PCR, are in clinical and hematological remission between 24 and 95 months after BMT. We conclude that aggressive chemotherapy combined with total body irradiation is unable to completely eradicate the malignant clone in all CML patients, and it might be speculated that other mechanisms (e.g., graft versus host reaction [GVHD] or graft versus leukemia effect [GVL]) may effectively eliminate residual leukemic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703441
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