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  • 1
    Electronic Resource
    Electronic Resource
    Prostaglandin E2 suppresses phytohemagglutin-induced immune responses of normal human monoculear cells by decreasing intracellular glutathione generation, but not due to increased DNA strand breaks or apoptosis (1993)
    Springer
    Inflammation research 40 (1993), S. 191-199 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prostaglandin E2 (PGE2) at concentrations more than 1×10−8 M markedly suppressed the cell proliferation and release of soluble molecules of interleukin-2 receptor (sIL-2R), CD4 (sCD4) and CD8 (sCD8) from phytohemagglutinin (PHA)-stimulated normal human mononuclear cells (MNC) in a dose-related manner. To further elucidate the subcellular mechanism of the inhibitory effect of PGE2 on PHA-stimulated MNC, intracellular concentration of glutathione (GSH) in PHA-stimulated MNC was sequentially measured from day 1 to day 3 by enzymic method. Furthermore, the effect of PGE2 on nuclear DNA including DNA strand breaks in alkali treatment and DNA fragmentation (apoptosis) of PHA-stimulated MNC were also measured. We found intracellular GSH levels were significantly decreased in the early stage of lymphocyte activation (day 1), but no evidence of increased DNA stand breaks or apoptotic process appeared in 3-day culture. In addition, butathione sulfoximine (a specific GSH inhibitor) and dibutyryl cyclic AMP also exhibited both proliferation inhibition and GSH-decreasing effect on PHA-stimulated MNC as well as PGE2. These results suggest that the immunosupressive effect of PGE2 is mediated by the decreased generation of intracellular GSH, but not by the increased DNA strand breaks or apoptotic mechanism in the cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01984061
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of additives upon Raney-Nickel alloy catalysts (1982)
    Springer
    Reaction kinetics and catalysis letters 21 (1982), S. 479-483 
    Details
    ISSN: 1588-2837
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Abstract Добавление малых количеств меди к никелю Ренея увеличивает его активность в гидрогенизации кротонового альдегида и его селективность в гидрогенизации связи C=O. Повышенные количества приводят к повышенной селективности, но к пониженной активности. Для обьяснения этого был использован подход химической координации на катализаторе.
    Notes: Abstract Addition of small amounts of copper to Raney Ni increases its activity for hydrogenation of crotonaldehyde and its selectivity for C=O bond hydrogenation. Higher amounts lead to higher selectivity but lower activity. The coordination chemical approach to catalysis was used to explain this result.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02095845
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of light alcohols from carbon monoxide and hydrogen over copper-iron catalysts (1988)
    Springer
    Reaction kinetics and catalysis letters 37 (1988), S. 487-492 
    Details
    ISSN: 1588-2837
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Abstract Исследованы активность и селективность медно-железных катализаторов синтеза легких спиртов из моноксида углерода и водорода. Определены благоприятное соотношение меди к железу и оптимальный химический состав катализатора.
    Notes: Abstract The activity and selectivity of copper-iron catalysts for the synthesis of light alcohols from carbon monoxide and hydrogen were studied. The suitable ratio of copper to iron and optimal chemical composition of the catalyst were determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02062104
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution of components in the rare earth ammonia synthesis catalysts and effect of additives (1989)
    Springer
    Reaction kinetics and catalysis letters 39 (1989), S. 207-212 
    Details
    ISSN: 1588-2837
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Abstract Распределение компонентов в катализаторе HG-1, промотированном окисями редкоземельных металлов (успешно разработанный авторами) и используемом в синтезе аммония, определяли на основе электронной микропробной фотографии. Объяснено влияние примесей на активность, а также исключительно большое время жизни катализатора.
    Notes: Abstract The distribution of components in the HG-1 ammonia catalyst promoted by rare earth oxide (successfully developed by the authors) was analyzed by electron microprobe photography. The results enable us to explain the effect of additives upon the activity as well as the remarkably high lifetime of catalyst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02061878
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    Paper (German National Licenses)
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