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  • 1
    Electronic Resource
    Electronic Resource
    Synthetic glucocorticoids potentiate IgE synthesis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 49 (1994), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recently, hydrocortisone (HC) has been shown significantly to enhance interleukin-4 (IL-4)-induced in vitro IgE synthesis. For investigation of possible effects of synthetic corticosteroids but also of effects of other important human hormones, peripheral blood mononuclear cells (PBMC) were incubated with IL-4 and various concentrations of the hormones. IgE secreted in the supernatant was determined after a 14-d culture period. Like HC, all synthetic corticosteroids potentiated IgE secretion. A minor effect was noted for the mineralocorticoid aldosterone. No modulating effect on IL-4-induced IgE formation was observed for adrenocorticotropic hormone (ACTH), somatotropin (STH), thyroid-stimulating hormone (TSH), triiodothyronine, thyroxine, epinephrine, noradrenaline, insulin, and glue agon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1994.tb02283.x
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  • 2
    Electronic Resource
    Electronic Resource
    Origin and Immunoregulation of Autoantibodies Against Intestinal Alkaline Phosphatase (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 41 (1995), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the sera of patients with acute bactetial infections specific autoantibodies (sIAPa) of the imtnuno-globulin class G (IgG) were found which bind to intestinal alkahne phosphatase (IAP) through the Fab portion. This was demonstrated using immunoaffinity (IA) isolation of sIAPa from patients' sera (particularly bacterial meningitis and ventriculitis) digestion with pepsin, purification of F(ab')2 fragments on protein A and subsequently binding on IAP coupled to CNBr (cyanogen bromide)-activated Sepharose. Immunoblots using specific anti-Fc and anti-Fab antibodies showed that the bulk of F(ab')2 fragments had bound. Additionally, binding of native IAP to the F(ab')2 fragments was observed after separation of F(ab')2 fragments using isoelectric focusing (IEF), blotting onto nitro cellulose and incubation with IAP. Moreover, we have demonstrated the occurrence of natural anti-IAP autoantibodies (nIAPa) which were isolated from sera of healthy individuals using IA chromatography. Investigation of isotype distribution revealed that IgG but not IgM or IgA were predominant even among nIAPa. The nIAPa fraction exhibited lower binding efficiencies on IEF blots than the sIAPa fraction, however, in contrast to sIAPa, cross-reactions with other autoantigens were observed for nIAPa. NIAPa and sIAPa did not show subclass restriction. As revealed by IEF the spectrotypes of sIAPa were found to be patient-specific, poly- to oligoclonal and stable during longer periods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1995.tb03586.x
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  • 3
    Electronic Resource
    Electronic Resource
    In vitro and in vivo effect of glucocorticoids on IgE and IgG subclass secretion (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hydrocortisone (HC) as well as its synthetic derivatives have been shown to strongly enhance interleukin-4 (IL-4)-induced in vitro IgE synthesis. To investigate possible effects on IgG subclasses, peripheral blood mononuclear cells (PBMC) were incubated with different glucocorticosteroids in the absence or presence of IL-4. The glucocorticoids alone led to a strongly enhanced secretion of IgG 1, IgG2 and IgG3, but not IgG4. The addition of IL-4 induced marked increases in IgG1 and IgG4, no changes in IgG3, but a consistent decrease in IgG2 synthesis. In order to find out whether these profound in vitro effects of corticosteroids are also reflected by changes in antibody serum levels during steroid treatment, 10 healthy volunteers took 25 mg prednisone for 7 consecutive days. We could not observe any significant changes of IgE or IgG subclass serum levels during or after this period. However, cell cultures performed after the glucocorticoid treatment revealed a marked decrease in the ability to produce IgG4 and a significantly lower potential to produce IgE in response to IL-4 alone or IL-4 and HC. We conclude that, although strongly implicated by the in vitro results, glucocorticosteroid treatment does not result in an increased allergy risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb02738.x
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  • 4
    Electronic Resource
    Electronic Resource
    Improved in vitro diagnosis of allergy to Alternaria tenius and Cladosporium herbarum (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 42 (1987), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To improve the in vitro diagnosis of mould allergy 22 children suffering from allergic asthma caused by Alternaria tenius and/or Cladosporium herbarum as proven by bronchial provocation test were investigated. Partially purified, standardized mould preparations were used in radioallergosorbent test (RAST) with conventional and new update mould discs, mould-induced histamine release and immunoblotting. Updated RAST discs were found to be superior to the old-type discs for the detection of Alternaria but not Cladosporium sensitivity. In all patients except one, specific IgE-antibodies to the respective mould were demonstrated by immunoblotting. Mould-induced histamine release failed to prove sensitization in only two patients. No differences were found comparing histamine release from whole blood with release from isolated cells. The results demonstrate a high sensitivity of in vitro tests when purified and standardized extracts are used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1987.tb00356.x
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  • 5
    Electronic Resource
    Electronic Resource
    IgE-Containing Circulating Immune Complexes in Churg-Strauss Vasculitis (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 21 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In five patients with vasculitis, hypereosinophilia, and elevated serum IgE levels a diagnosis of Churg-Strauss syndrome was established. To identify a possible role of IgE in pathogenic mechanisms leading to the vasculitis, we performed a sequential precipitation of the patients'sera with different concentrations of polyethylene glycol (PEG) 6000. Using a radio immunosorbent test, we tested the precipitates obtained for IgE. Considerable amounts of IgE were traced in the serum precipitates of all patients, especially after the second precipitation step (4.0% PEG). In contrast, no IgE-containing precipitates were detectable in sera from patients with different allergic diseases and high IgE serum levels. Together with an increase in C3d serum levels and the failure to demonstrate Clq-binding material in patients' sera, these data suggest the involvement of IgE-containing immune complexes in the pathogenesis of Churg-Strauss vasculitis, activating the complement via the alternate pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01443.x
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  • 6
    Electronic Resource
    Electronic Resource
    Multiple peripheral pulmonary nodules preceding rheumatoid arthritis (1987)
    Springer
    Rheumatology international 7 (1987), S. 89-91 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Lung manifestations ; Pulmonary nodules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a young woman is reported, presenting multiple peripheral lung nodules, preceding the onset of classical rheumatoid arthritis 3 months later. The nodules observed seemed to be of pleural origin because they all had contact with the pleura which was partly thickened as demonstrated by computer-assisted tomography. The histopathology of material obtained by an open-lung biopsy revealed rheumatoid necrobiotic nodules. Although very rare, rheumatoid arthritis should be considered as a differential diagnosis of pulmonary nodules of unknown origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270313
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  • 7
    Electronic Resource
    Electronic Resource
    IGM-containing immune complexes and antiphospholipid antibodies in patients with Sneddon's syndrome (1989)
    Springer
    Rheumatology international 9 (1989), S. 43-48 
    Details
    ISSN: 1437-160X
    Keywords: Sneddon's syndrome ; Immune complexes ; Antiphospholipid antibodies ; Von Willebrand factor antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report three patients with a Sneddon syndrome in whom predominantly small (500–900 kD) IgM-containing serum immune complexes were detectable. Furthermore, antiphospholipid antibodies and increased von Willebrand factor antigen were found in the sera of two cases. Especially the data demonstrating small circulating immune complex as suggest that Sneddon's syndrome, a rare vasculitis disorder, might immunologically be characterized by circulating IgM-containing immune complexes which, in addition, could play a role in the pathogenesis of this disease entity. The elevated antiphospholipid antibodies as well as the increased von Willebrand factor antigen in the sera of the investigated patients have to be considered as nonspecific vasculitis-associated phenomena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270289
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  • 8
    Electronic Resource
    Electronic Resource
    Intralymphatic interleukin-2 treatment of a hemophiliac AIDS patient with defective interleukin-2 production (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 380-386 
    Details
    ISSN: 1432-1440
    Keywords: Interleukin-2 ; Intralymphatic treatment ; AIDS ; Pneumocystis carinii pneumonia ; Immune response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To improve immune functions in an interleukin-2 (IL-2) deficient hemophiliac AIDS patient suffering from severePneumocystis carinii pneumonia, treatment with IL-2 was started in addition to standard antimicrobioal therapy. Highly purified IL-2 was administered subcutaneously and then repeatedly intralymphatically in a manner similar to pedal lymphography. No toxicity was observed. The patient temporarily improved clinically as well as with regard to immunological functions. Particularly the in vitro response to phytohemagglutinin (PHA) could partly be restored, and skin tests revealed improved response to recall antigens. These findings indicate that IL-2 can be administered safely and effectively by the intralymphatic route and may — in addition to antibiotics — be of value in AIDS patients with severe opportunistic infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745579
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  • 9
    Electronic Resource
    Electronic Resource
    Seltene Manifestation einer Großgefäßvaskulitis bei systemischem Lupus erythematodes (2000)
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 330-333 
    Details
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Lupus erythematodes –¶Großgefäßvaskulitis – Histologie ; Key words Lupus erythematosus – large-vessel vasculitis – histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Case-reports from two female patients with an occlusion of the right external iliac artery and femoral artery are presented due to a large-vessel vasculitis. Both patients suffered from systemic lupus erythematosus This rare manifestation occured within the first few years of the disease and was important for prognosis and further treatment. Other manifestations of the disease were general symptoms and polyarthritis. In one case the vascultitis was confirmed by histology.¶   A fibrous thickening of the intima and a vasculitis of small vessels within the adventitia were the prominent feature. This observation supports the idea of small vessel vasculitis as the characteristic manifestation in lupus erythematosus.
    Notes: Zusammenfassung Zwei Fallberichte dokumentieren den Verschluss der Arteria iliaca externa bzw. der Arteria femoralis superficialis rechts bei Patientinnen mit einem systemischen Lupus erythematodes im Rahmen einer Großgefäßvaskulitis. Diese sehr selten beschriebene Manifestation trat innerhalb der ersten Jahre der Autoimmunerkrankung auf und war für Prognose und Therapie bestimmend. Ansonsten waren bei beiden Patienten Allgemeinsymptome und eine Gelenkbeteiligung als weitere Manifestation der Grunderkrankung anzusehen. In einem Fall konnte eine histologische Sicherung der Vaskulitis erfolgen. Dabei war eine fibrinöse Verdickung der Intima und eine Vaskulitis der kleinen Arterien in der Adventitia auffällig. Diese Beobachtung unterstützt die Annahme, dass die sekundäre Vaskulitis im Rahmen eines Lupus erythematodes eigentlich als Kleingefäßvaskulitis aufzufassen ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930070055
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  • 10
    Electronic Resource
    Electronic Resource
    Different patterns of antigen-induced histamine release during immunotherapy in insect venom and pollen allergy (1986)
    Springer
    Inflammation research 18 (1986), S. 248-250 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antigen-induced histamine release from whole blood was shown to be a suitable parameter for the diagnosis of hypersensitivity in both patients allergic to bee or wasp venom as well as in patients suffering from seasonal tree pollen allergy. Although both groups were treated successfully by specific immunotherapy, only in patients with insect allergy venom induced histamine release decreased significantly during therapy, whereas, in the patient with pollinosis, pollen induced histamine release did not change significantly during or after treatment. This discrepancy in the antigen-induced histamine release could either be due to different routes of immunization with the allergen and/or is caused by the atopic status which is prevalent in patients with pollinosis but not in insect allergic subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01988033
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