Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Alteration of alveolar surfactant function after exposure to oxidative stress and to oxygenated and native arachidonic acid in vitro
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 835 (1985), S. 58-67 
    Details
    ISSN: 0005-2760
    Keywords: (Rabbit lung) ; Arachidonic acid ; Free radical ; Lung surfactant ; Oxidative stress ; Surface tension behavior
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(85)90030-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Increased pulmonary vascular resistance and permebility due to arachidonate metabolism in isolated rabbit lungs
    Amsterdam : Elsevier
    Prostaglandins 23 (1982), S. 157-173 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(82)90043-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Influence of tocopherol, its chromane compound, phytyl chains and superoxide dismu8tase on increased vascular resistance and permeability due to arachidonate metabolism in isolated rabbit lung
    Amsterdam : Elsevier
    Prostaglandins 23 (1982), S. 175-184 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(82)90044-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    L-α-phosphatidic acid : Ca-Ionophore with stimulation of the arachidonic acid cascade in the pulmonary vascular bed
    Amsterdam : Elsevier
    Prostaglandins 27 (1984), S. 69 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(84)90314-9
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Influence of B2 receptor antagonists on bradykinin-induced vasodilation and edema formation in isolated rabbit hindlimbs (1995)
    Springer
    Inflammation research 44 (1995), S. 212-216 
    Details
    ISSN: 1420-908X
    Keywords: Bradykinin ; BK2 receptor antagonists ; Rabbit hindlimbs preparation ; Edema formation ; Peripheral vasodilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In search of new possibilities to prevent acute inflammatory vascular reaction, we examined the effect of two selective B2 receptor antagonists, CP 0127 ([Bissuccimidohexane (L-Cys6)−1] and HOE 140 (D-Arg[Hyp3, Thi5, D-Tic7, Oic8]BK), on changes in perfusion pressure and on edema formation caused by bradykinin (BK) in the isolated perfused rabbit hindlimbs. CP 0127 and HOE 140 were added to the perfusion fluid 2 min prior to the first BK-administration (5 × 10−9 mol/l). A second BK-stimulation was performed after 30 minutes. The antagonists were tested in groups of 6 experiments each at concentrations of 10−6 mol/l, 5 × 10−9 mol/l and 10−10 mol/l. CP 0127 was also tested in a concentration of 10−8 mol/l. The application of BK resulted in an acute decrease of the mean arterial pressure and in a continual edema formation, reflected by an increase of organ weight (controls,n=6). Pretreatment with CP 0127 as well as with HOE 140 attenuated dose-dependently the BK-induced vasodilation (p 〈 0.005) and edema formation. The current results indicate that CP 0127 and HOE 140 are able to reduce BK-induced effects on vascular tone and edema formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01782261
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Impairment of bacterial clearance induced by norepinephrine infusion in rabbits (1996)
    Springer
    Intensive care medicine 22 (1996), S. 637-643 
    Details
    ISSN: 1432-1238
    Keywords: Bacterial clearance ; E. coli bacteremia ; Endotoxin ; Norepinephrine ; Reticuloendothelial system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective Purpose of the study was to investigate the potential influence of norepinephrine (NE) on immune functions in terms of systemic and organ-specific bacterial clearance in rabbits. Design To enable quantification of the clearance process, defined numbers of exogenousEscherichia coli (1.3×108 CFU) were injected intravenously 60 min after starting the NE infusion at a low dose (1 μg/kg per min,n=6), causing an increase (30 mmHg) in mean arterial pressure without affecting the oxygen uptake, and at a higher dose (7.5 μg/kg per min,n=6), resulting in a marked decrease (20%) in oxygen uptake, after infusion of NaCl solution (control,n=6). In additional experiments (n=6) NE (1 μg/kg per min) was tested in endotoxemia induced by simultaneous infusion of endotoxin (40 μg/kg per h). Parameters monitored were arterial pressure, oxygen uptake, and rates of bacterial elimination from the blood. At 180 min afterE. coli injection, the animals were sacrificed, and tissue samples of liver, kidney, spleen, and lung were collected for bacterial counts. Results NE infusion resulted in a dose-dependent prolonged elimination of the injectedE. coli from the blood and in significantly higher (p〈0.05) numbers of CFU in liver and lung compared to the controls. Significant impairment of bacterial clearance was found after shockproducing endotoxemia, whereas simultaneous infusion of NE and endotoxin caused only a slightly delayed blood clearance of the injected bacteria. Conclusion NE dose dependently affected bacterial clearance, which might be due to ischemia-derived hypoxic impairment of the phagocytosis and lysis function of the reticuloendothelial system, whereas NE improved elimination of bacteria in a state of endotoxic shock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709739
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The role of endothelin-1 as a mediator of the pressure response after air embolism in blood perfused lungs (1998)
    Springer
    Intensive care medicine 24 (1998), S. 605-611 
    Details
    ISSN: 1432-1238
    Keywords: Key words Air injection ; Embolism ; Endothelin ; Thromboxane ; Vascular resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: It is well known that lung embolism is associated with an increase in pulmonary vascular resistance. Since the mechanisms of pulmonary vascular reactions during embolism are still unclear, the aim of this study was to investigate the potential involvement of endothelin-1 (ET-1) and thromboxane A2 (TXA2) as mediators of the pulmonary artery pressure (PAP) increase after embolism using the selective ETA receptor antagonist LU135 252 [1], the ETB receptor antagonist BQ788 [2], and the cyclooxygenase inhibitor diclofenac. Design: Prospective experimental study in rabbits. Setting: Experimental laboratory in a university teaching hospital. Subjects: 36 adult rabbits of either sex. Interventions: The experiments were performed in 36 isolated and ventilated rabbit lungs which were perfused with a buffer solution containing 10 % of autologous blood. Embolism was induced by the injection of 0.75 ml air into the pulmonary artery. Measurements and results: PAP and lung weight, reflecting edema formation, were continuously recorded. Perfusate samples were drawn intermittently to determine TXA2 and ET-1 concentrations. Air injection resulted in an immediate increase in PAP up to 22.8 ± 1.4 mm Hg at 2.5 min (control, n = 6), which was parallelled by an enhanced generation of TXA2. No relevant edema formation occurred during the observation period. Pretreatment with the ETA receptor antagonist LU135 252 significantly reduced the pressure reaction after air embolism (p 〈 0.001) whereas the ETB receptor antagonist BQ788 (n = 6) was without marked effects. The administration of diclofenac (n = 6) did not alter the PAP increase 2.5 min after embolism, but significantly reduced the pressure reaction during the further observation period (p 〈 0.001). The application of LU135 252 and diclofenac together (n = 6) also significantly reduced the PAP increase from 2.5 min during the total observation period (p 〈 0.001). Conclusions: The acute pressure reaction after air embolism is mainly mediated via ET-1 by an ETA receptor related mechanism. TXA2 seems to maintain this reaction for a longer time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050622
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Impairment of bacterial clearance induced by norepinephrine infusion in rabbits (1996)
    Springer
    Intensive care medicine 22 (1996), S. 637-643 
    Details
    ISSN: 1432-1238
    Keywords: Key words Bacterial clearance ; E. coli bacteremia ; Endotoxin ; Norepinephrine ; Reticuloendothelial system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   Objective: Purpose of the study was to investigate the potential influence of norepinephrine (NE) on immune functions in terms of systemic and organ-specific bacterial clearance in rabbits. Design: To enable quantification of the clearance process, defined numbers of exogenous Escherichia coli (1.3×108 CFU) were injected intravenously 60 min after starting the NE infusion at a low dose (1 μg/kg per min, n=6), causing an increase (30 mmHg) in mean arterial pressure without affecting the oxygen uptake, and at a higher dose (7.5 μg/kg per min, n=6), resulting in a marked decrease (20%) in oxygen uptake, after infusion of NaCl solution (control, n=6). In additional experiments (n=6) NE (1 μg/kg per min) was tested in endotoxemia induced by simultaneous infusion of endotoxin (40 μg/kg per h). Parameters monitored were arterial pressure, oxygen uptake, and rates of bacterial elimination from the blood. At 180 min after E. coli injection, the animals were sacrificed, and tissue samples of liver, kidney, spleen, and lung were collected for bacterial counts. Results: NE infusion resulted in a dose-dependent prolonged elimination of the injected E. coli from the blood and in significantly higher (p〈0.05) numbers of CFU in liver and lung compared to the controls. Significant impairment of bacterial clearance was found after shock-producing endotoxemia, whereas simultaneous infusion of NE and endotoxin caused only a slightly delayed blood clearance of the injected bacteria. Conclusion: NE dose dependently affected bacterial clearance, which might be due to ischemia-derived hypoxic impairment of the phagocytosis and lysis function of the reticuloendothelial system, whereas NE improved elimination of bacteria in a state of endotoxic shock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709739
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Hemodynamic Reactions Induced by Streptokinase Therapy in Patients with Acute Myocardial Infarction (1975)
    Springer
    Intensive care medicine 1 (1975), S. 27-30 
    Details
    ISSN: 1432-1238
    Keywords: Acute Myocardial Infarction ; Streptokinase ; Heparin ; Total Peripheral Resistance ; Mean Arterial Pressure ; Cardiac Output ; Oxygen Uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In patients with acute myocardial infarction a significant decrease of total peripheral resistance averaging 21 % is induced by fibrinolytic treatment with streptokinase. At the same time mean arterial blood pressure tends to drop, and cardiac output to increase. These changes were not observed under heparin therapy. The cause and importance of this hemodynamic reaction are discussed, and the observed effect of streptokinase therapy is considered to have a favourable influence on the damaged heart and on the microcirculation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735866
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Cardiovascular reactions induced by leucocidin fromPseudomonas aeruginosa (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 294 (1976), S. 85-89 
    Details
    ISSN: 1432-1912
    Keywords: Cardiovascular failure ; Leucocidin ; Pseudomonas aeruginosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Leucocidin fromPseudomonas aeruginosa causes cardiovascular failure in rats and mice. The time between i.v. injection and death depends on the dose. After injection of high doses (500 μg/kg) the arterial blood pressure decreases rapidly and cardiac irregularities and AV block occur within about 5 min. In contrast to endotoxin shock no pulmonary hypertension was observed, whereas portal hypertension was seen in our experiments. Injection of lower doses (〈200 μg/kg) caused peripheral vascular damage with lung oedema, vascular disturbances in various tissues, exudation and bleeding. Finally cardiac insufficiency predominated. Dexamethasone delayed the symptoms but did not prevent death in either rats or mice. Heparin was ineffective in this type of shock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692788
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...