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  • 1
    Electronic Resource
    Electronic Resource
    Status of the compact synchrotron radiation source cosy and first exposure experiments
    Amsterdam : Elsevier
    Microelectronic Engineering 13 (1991), S. 291-294 
    Details
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-9317(91)90096-V
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  • 2
    Electronic Resource
    Electronic Resource
    CD 34 Immunotyping of blasts in myelodysplasia (1994)
    Springer
    Annals of hematology 68 (1994), S. 77-80 
    Details
    ISSN: 1432-0584
    Keywords: Myelodysplastic syndromes ; Refractory anemia with excess of blasts ; Chronic myelomonocytic leukemia ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the expression of the hematopoietic progenitor cell antigen CD 34 in six patients with refractory anemia with excess of blasts (RAEB), five patients with RAEB in transformation (RAEB-T), and seven patients with chronic myelomonocytic leukemia (CMML). Immunocytochemical labeling of bone marrow cells was performed by an indirect immunoperoxidase method with preservation of morphological details. The cells were stained with May-Grünwald-Giemsa, photographed, destained, and immunolabeled by the immunoperoxidase technique. We found 1.5±0.5% blasts and 0.8±0.4% CD 34+ blasts in normal bone marrow. The CD 34 positivity of blasts was 53±9%. The patients with RAEB showed 1.7±1.4% CD 34+ blasts. The CD 34 positivity of blasts (11.8±5.6%) was lower than in normal bone marrow. The patients with RAEB-T had a higher percentage of CD 34+ blasts (7.3∓3.4) and a higher CD 34 positivity of blasts (28.2±14.6%) than patients with RAEB. The CMML patients showed a percentage of CD 34+ blasts and a CD 34 positivity of blasts in the range of RAEB. We found an increase of promonocytes (PMC) in 5/7 patients. In some patients the PMC were CD 34 positive. Our results indicate that the increase of blasts in REAB is related to CD 34-negative blasts. With progression to RAEB-T the percentage of CD 34-positive blasts increased. Some of the CMML patients also showed a population of CD 34-positive PMC. A clone of undifferentiated CD 34-positive cells is characteristic for patients with these types of myelodysplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715135
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  • 3
    Electronic Resource
    Electronic Resource
    Immunotyping of blasts in human bone marrow (1996)
    Springer
    Annals of hematology 72 (1996), S. 125-129 
    Details
    ISSN: 1432-0584
    Keywords: Key words Immunocytochemistry ; Bone marrow ; Myeloblast ; Hematopoietic progenitor cells ; CD34 antigen ; c-kit antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The diagnostic potential of immunocytochemical investigation of human bone marrow has not been fully realized due to difficulties in morphological identifying of immunostained cells. We used an indirect immunoperoxidase technique after May-Grünwald-Giemsa staining for simultaneous morphological and immunocytochemical analysis of blasts in human bone marrow. Six healthy bone marrow donors were investigated. Most blasts I expressed CD34 ,CD38 and HLA-DR. Expression of c-kit (CD117) was observed on 42±9% of blasts I. Granulocytomonocytopoietic character was demonstrated by expression of CD13 (33±15%) and CD45RA (23±10%) and erythropoietic character was demonstrated by expression of CD36 (22±8%) and CD45RO (30±11%). A very low proportion of blasts I were Thy-1 and CD61 positive; 34±6% of blasts I expressed CD22, representing B lymphoid committed progenitors. CD3, CD15, and glycophorin A expression was not detected. Blasts II and III and proerythroblasts did not show CD34 positivity. We conclude that blasts I are morphologically identifiable cells with a high percentage of CD34, CD38, and HLA-DR positivity. They are a pool of committed progenitor cells for erythropoiesis, granulocytomonocytopoiesis, megakaryocytopoiesis, and B cell development. Blast II and proerythroblast represent the first morphologically identifiable cells of granulocytopoiesis and erythropoiesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050149
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  • 4
    Electronic Resource
    Electronic Resource
    Taurine Biosynthesis in Rat Brain: A New Specific and Sensitive Microassay of Cysteine Sulfinate Decarboxylase (CSDI) Activity Through Selective Immunotrapping and Its Use for Distribution Studies (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 48 (1987), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Cysteine sulfinate decarboxylase (CSD), the putative biosynthetic enzyme for taurine, has been shown to exist in two forms in rat brain, respectively CSDI and CSDII, one of which (CSDII) is considered to be in fact glutamate decarboxylase (GAD). CSDI assay after immunotrapping was made possible by using an anti-CSD antiserum raised in sheep immunized with a partially purified CSD fraction from liver. This antiserum immunoprecipitated both liver CSD and brain CSDI activities with the same affinity but did not inhibit their enzymatic activities. The immunotrapping of CSDI was selective without any contamination by GAD/CSDII activity. The immunotrapped CSD activity, which corresponded exactly to the amount of CSD not precipitated by a GAD/CSDII antiserum, was not inhibited by a specific irreversible GAD inhibitor. A quantitative, selective and sensitive assay was thus developed by measuring CSD activity on the solid phase after immunotrapping. Kinetic parameters of the immunotrapped enzyme remained unchanged. CSDI activity represented only a fraction, around 20% with saturating concentration of substrate, of the total CSD activity in rat brain homogenate. This indicates that most studies on total CSD activity dealt essentially with CSDII activity that is indeed GAD. Regional and subcellular distributions of CSDI have been determined. CSDI activity was about threefold higher in the richest (cerebellum) compared to the poorest (striatum) region without any correlation with GAD/CSDII distribution. Subcellular distribution showed a fourfold enrichment of CSDI activity in the synaptosomal fraction. The precise role of CSDI and CSDII in the biosynthesis of taurine in vivo remains to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1987.tb04100.x
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  • 5
    Electronic Resource
    Electronic Resource
    Detailed atomic scale structure of AlInAs/GaInAs quantum wells (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 65 (1989), S. 2688-2692 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Quantification of high-resolution transmission electron microscopy (HRTEM) lattice images and detailed luminescence line-shape analysis is used to determine the atomic structure of GaInAs quantum wells (QWs) between AlInAs barriers. By careful analysis of a statistically large number of HRTEM images, we are able to measure the standard deviation in the mean quantum-well width to better than one (200) monolayer. Statistical analysis of the temperature dependence of the luminescence yields QW width distribution functions and variations of the mean QW width across the sample with a precision of better than 0.2 nm in quantitative agreement with the transmission electron microscopy results. No large and smooth islands with monolayer steps in between but rather long-range mean band-gap fluctuations are observed. Spectral broadening is found to be induced by well-width-dependent roughness of inequivalent growth surfaces and by clustering in the barriers for extremely narrow wells of the order Lz≈1 nm. Our results indicate a pronounced surface roughening of InGaAs at 640 °C. The mean height of steps of a maximum width of 5 nm at the InGaAs surface increases from 1 to 2 monolayers for an increase of well width from ≈1 to 2.5 nm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.342753
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  • 6
    Electronic Resource
    Electronic Resource
    Nuclear diagnostics for the National Ignition Facility (invited) : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 773-779 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The National Ignition Facility (NIF), currently under construction at the Lawrence Livermore National Laboratory, will provide unprecedented opportunities for the use of nuclear diagnostics in inertial confinement fusion experiments. The completed facility will provide 2 MJ of laser energy for driving targets, compared to the approximately 40 kJ that was available on Nova and the approximately 30 kJ available on Omega. Ignited NIF targets are anticipated to produce up to 1019 DT neutrons. In addition to a basic set of nuclear diagnostics based on previous experience, these higher NIF yields are expected to allow innovative nuclear diagnostic techniques to be utilized, such as neutron imaging, recoil proton techniques, and gamma-ray-based reaction history measurements. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1319356
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  • 7
    Electronic Resource
    Electronic Resource
    Development of a neutron imaging diagnostic for inertial confinement fusion experiments : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 865-868 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Pinhole imaging of the neutron production in laser-driven inertial confinement fusion experiments can provide important information about the performance of various capsule designs. This requires the development of systems capable of spatial resolutions on the order of 5 μm or less for source strengths of 1015 and greater. We have initiated a program which will lead to the achievement of such a system to be employed at the National Ignition Facility (NIF) facility. Calculated neutron output distributions for various capsule designs will be presented to illustrate the information which can be gained from neutron imaging and to demonstrate the requirements for a useful system. We will describe the lines-of-sight available at NIF for neutron imaging and explain how these can be utilized to reach the required parameters for neutron imaging. We will describe initial development work to be carried out at the Omega facility and the path which will lead to systems to be implemented at NIF. Beginning this year, preliminary experiments will be aimed at achieving resolutions of 30–60 μm for direct-drive capsules with neutron outputs of about 1014. The main thrust of these experiments will be to understand issues related to the fabrication and alignment of small diameter pinhole systems as well as the problems associated with signal-to-background ratios at the image plane. Subsequent experiments at Omega will be described. These efforts will be aimed at achieving resolutions of about 10 μm. Proposed developments for new imaging systems as well as further refinement of pinhole techniques will be presented. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1329883
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  • 8
    Electronic Resource
    Electronic Resource
    Neutron time-of-flight and emission time diagnostics for the National Ignition Facility : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 850-853 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Current plans call for a system of current mode neutron detectors for the National Ignition Facility for extending the range of neutron yields below that of the neutron activation system, for ion-temperature measurements over a wide yield range, and for determining the average neutron emission time. The system will need to operate over a yield range of 106 for the lowest-yield experiments to 1019 for high-yield ignited targets. The requirements will be satisfied using several detectors located at different distances from the target. This article presents a conceptual design for the NIF nToF system. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1321001
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  • 9
    Electronic Resource
    Electronic Resource
    Multipurpose 10 in. manipulator-based optical telescope for Omega and the Trident laser facilities : Proceedings of the 12th topical conference on high temperature plasma diagnostics (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 803-805 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We have recently designed and are building a telescope which acts as an imaging light collector relaying the image to an optical table for experiment dependent analysis and recording. The expected primary use of this instrument is a streaked optical pyrometer for witness plate measurements of the hohlraum drive temperature. The telescope is based on the University of Rochester's 10 in. manipulator (TIM) which allows compatibility between Omega, Trident, and the NIF lasers. The optics capture a f/7 cone of light, have a field of view of 6 mm, have a spatial resolution of 5–7 μm per line pair at the object plane, and are optimized for operation at 280 nm. The image is at a magnification of 11.7×, which is convenient for many experiments, but can be changed using additional optics that reside outside the TIM. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149403
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  • 10
    Electronic Resource
    Electronic Resource
    Dual microchannel plate module for a gated monochromatic x-ray imager : Proceedings of the eleventh topical conference on high temperature plasma diagnostics (1997)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 789-791 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Development and testing of a dual microchannel plate (MCP) module to be used in the national inertial confinement fusion (ICF) program has recently been completed. The MCP module is a key component of a new monochromatic x-ray imaging diagnostic which is designed around a four channel Kirkpatrick–Baez microscope and diffraction crystals and is located at the University of Rochester's Omega laser system. The MCP module has two separate MCP regions with centers spaced 53 mm apart. Each region contains a 25 mm MCP proximity focused to a P-11 phosphor coated fiberoptic faceplate. The two L/D=40, MCPs have a 10.2 mm wide, 8 ohm stripline constructed of 500 nm copper overcoated with 100 nm gold. A 4 kV, 150 ps electrical pulse provides an optical gatewidth of 80 ps and spatial resolution has been measured at 20 lp/mm. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1147742
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