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  • 1
    Electronic Resource
    Electronic Resource
    X-rays from proton-antiproton annihilation into charged final states
    Amsterdam : Elsevier
    Nuclear Physics, Section A 495 (1989), S. 451-462 
    Details
    ISSN: 0375-9474
    Keywords: Atomic Physics ; measured annihilation X-ray spectrum
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(89)90354-0
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  • 2
    Electronic Resource
    Electronic Resource
    Macrophages and their subpopulations following allogeneic bone marrow transplantation for chronic myeloid leukaemia (2000)
    Springer
    Virchows Archiv 437 (2000), S. 160-166 
    Details
    ISSN: 1432-2307
    Keywords: Key words Macrophages ; Pseudo-Gaucher cells ; Chronic myeloid leukaemia ; Bone marrow transplantation ; Bone marrow biopsies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A morphometric and immunohistochemical study was performed on 354 bone marrow trephine biopsies derived from 126 patients with chronic myeloid leukaemia (CML) before and after allogeneic bone marrow transplantation (BMT). The purpose of this investigation was to evaluate the macrophage population, including several subsets and their dynamics in the posttransplant period. In addition to the total CD68+ resident (mature) macrophages the so-called activated fraction identified by its capacity to express α-d-galactosyl residues, the pseudo-Gaucher cells (PGCs) and the iron-laden histiocytic reticular cells were also considered. Following immuno- and lectin-histochemical staining morphometric analysis was carried out on sequential postgraft bone marrow specimens at standardized intervals. Compared to the normal bone marrow and calculated per haematopoiesis (cellularity) an overall decrease of about 40–50% in the quantity of CD68+ macrophages and the BSA-I+ subpopulation was detectable in the early posttransplant period (9–45 days after BMT). Noteworthy was the temporal recurrence of PGCs in the engrafted bone marrow, which was not associated with a clonally transformed cell population or leukaemic relapse. Reappearance of postgraft PGCs was most prominent in the first 2 months after BMT. This conspicuous feature was presumed to be functionally associated with a pronounced degradation of cell debris following pretransplant myelo-ablative therapy (scavenger macrophages). Evidence for an activation of the BSA-I+ macrophage subset was derived from the identical carbohydrate-binding capacity shown by the PGCs. In the regenerating haematopoiesis shortly after BMT a significant correlation between the number of BSA-I+ macrophages and erythroid precursor cells was determinable. This result implicates a close functional relationship between postgraft reconstitution of erythropoietic islets and centrally localized activated macrophages. In conclusion, findings emerging from this study included the reappearance of PCGs in the engrafted bone marrow independently of a leukaemic relapse and the significant association of the activated BSA-I+ macrophage subset with the recovery of erythropoiesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000224
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  • 3
    Electronic Resource
    Electronic Resource
    Bone marrow transplantation for chronic granulocytic leukaemia (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 560-564 
    Details
    ISSN: 1432-1440
    Keywords: Chronic granulocytic leukaemia ; Bone marrow transplantation ; Graft-versus-host disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-one patients with chronic granulocytic leukaemia underwent marrow transplantation. The donors were human-lymphocyte antigen-identical siblings in 19 cases. In the remaining 2 cases the donor was a parent in one and an identical twin in the other. The preparatory regimen included cyclophosphamide and 8.6 Gy total body irradiation given at either a dose of 0.1 Gy/min or 0.04 Gy/min. Five patients were in the accelerated phase of the disease, one was in remission following blast crisis, and the rest were all in the chronic phase. After chemotherapy and irradiation, all patients received bone marrow transplants. To date, nine patients are still alive, with a median survival of 64 days (range 28–683 days). One patient continued to have leukaemic cells and in another, the leukaemia recurred 18 months following transplantation. Interstitial pneumonitis was the cause of death of eight patients (38%). Graft-versus-host disease occurred in ten patients (47%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733201
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  • 4
    Electronic Resource
    Electronic Resource
    Alveolo-Capillary Protein Permeability and Lung Function in Patients with Late Pulmonary Complications after Allogeneic Bone Marrow Transplantation (1998)
    Springer
    Lung 176 (1998), S. 99-109 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Alveolo-capillary leakage—BAL—BMT—Lung function—Pulmonary complications.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A prospective study was performed to identify markers predictive for the development of pulmonary complications in the early (〈50 days) and late (〉50 days) phase after bone marrow transplantation (BMT). The characterization of BMT patients with early or late pulmonary complications revealed clear-cut differences. Early and long term increase of alveolo-capillary protein permeability was associated with smoking and was found in 20 patients developing pulmonary complications within 50 days after BMT (group 1). The 22 patients who developed such complications thereafter (group 2) had more acute graft vs host disease than 66 patients who remained free of these complications for a minimum of 1 year. Concentrations of bronchoalveolar lavage (BAL) fluid albumin (alb) and serum β2-microglobulin (S-β2m) were determined 10 days before BMT, on days 1, 30, and 40 after BMT, whereas lung function tests were performed before BMT, after discharge from the hospital, and 6 months as well 1 year after BMT. Using cut-off values for BAL fluid alb (〉2.3 mg/dl) and S-β2m (〉0.8 mg/liter) we could significantly discriminate 12 patients out of 19 group 1 patients (early pulmonary complications) as well as 9 out of 21 group 2 patients (late pulmonary complications) from 12 out of 64 group 3 patients (without such complications) 1 day after BMT. Our results demonstrate that early increased alveolo-capillary protein permeability defines a patient population at risk to develop pulmonary complications later than 50 days after BMT with up to 1 year significantly decreased lung volumes (FEV1, 73% predicted, VC, 85% predicted).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007598
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  • 5
    Electronic Resource
    Electronic Resource
    Konservierung von hämopoetischen Stammzellen (1975)
    Springer
    Journal of cancer research and clinical oncology 83 (1975), S. 285-291 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das CFU-S-Potential von Mausknochenmark, das Transplantationspotential von autologem und allogenem Affenknochenmark sowie das CPU-C-Potential von menschlichem Knochenmark kann ohne Vitalitätsverlust eingefroren und wieder aufgetaut werden. Eine wichtige Voraussetzung für eine optimale Stammzellrecovery ist, daß die intrazellulären protektiven Substanzen Glycerin oder DMSO durch langsam stufenweise Verdünnung nach dem Auftauen entfernt werden, damit eine osmotische Schädigung der Zellen vermieden wird.
    Notes: Summary The CFU-S potential of mouse bone marrow, the transplantation capacity of autologous and allogeneic monkey bone marrow and the CPU-C potential of human bone marrow can be cryopreserved without loss of viability. It is critical for an optimal stem cell recovery to avoid an osmotic shock after thawing. The intracellular cryoprotectives glycerol and DMSO which provide a high osmotic pressure should be removed from the thawed cells by a slow stepwise dilution procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00573015
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  • 6
    Electronic Resource
    Electronic Resource
    Die intraoperative Radiotherapie als Bestandteil multimodaler Therapiekonzepte bei epithelialen Tumoren des Gastrointestinaltrakts (2000)
    Springer
    Der Chirurg 71 (2000), S. 682-691 
    Details
    ISSN: 1433-0385
    Keywords: Keywords: Intraoperative irradiation ; Gastrointestinal carcinoma ; Recurrent rectal carcinoma ; Multimodal therapy. ; Schlüsselwörter: Intraoperative Radiotherapie ; gastrointestinale Carcinome ; Rectumcarcinomrezidiv ; multimodale Therapie.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Durch intraoperative Strahlentherapie (IORT) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhöht. Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Überlebensrate gegenüber konventionellen Therapieregimen beim fortgeschrittenen primären Rectumcarcinom und Carcinomrezidiv verbessert werden. Dagegen ist bisher nur in wenigen Studien über eine verbesserte Überlebensrate durch zusätzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden. Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle, nicht aber die Überlebensrate verbessert, da häufig Leber- und Peritonealmetastasen auftreten. Für das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor.
    Notes: Abstract. Surgery alone often fails to achieve local control in advanced gastrointestinal tumors. With multimodal therapy approaches, both local tumor control and long-term survival appear to be improved. Intraoperative radiation therapy (IORT) is an attempt to achieve higher doses of irradiation while dose-limiting structures are surgically displaced. It has been shown previously that both local tumor control and long-term survival are improved in patients undergoing surgery combined with IORT for both primary and recurrent rectal carcinoma. In advanced gastric carcinoma, IORT has achieved optimistic survival results in a few studies. In locally advanced pancreatic cancer, an apparent improvement in local control has been noted with IORT, but survival has not been prolonged because of a high incidence of both liver and peritoneal metastases. The data concerning IORT for esophageal carcinoma are not yet sufficient to allow judgement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040051120
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  • 7
    Electronic Resource
    Electronic Resource
    Sensibilisierungsversuche an Meerschweinchen mit fünf parasubstituierten Benzolderivaten (1978)
    Springer
    Archives of dermatological research 261 (1978), S. 153-161 
    Details
    ISSN: 1432-069X
    Keywords: 5-para-amino-compounds ; Epicutane sensitization on guinea pigs ; Fünf parasubstituierte Benzolderivate ; 5 Parastoffe ; Epicutane Sensibilisierung an Meerschweinchen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir haben an 160 Meerschweinchen epicutane Sensibilisierungsversuche mit parasubstituierten Benzolderivaten in 4 Konzentrationsstufen durchgeführt und die Beurteilung der Testreaktionen nach makroskopischen und histologischen Kriterien vorgenommen. Den mit jeder Substanz an 32 Tieren gewonnenen Ergebnissen ist zu entnehmen, daß Sensibilisierungen eingetreten sind mit p-Aminodiphenylamin in etwa 50%, mit p-Toluylendiamin in etwa 25%, mit p-Phenyldiamin in 62% (bei 1- und 2%iger Konzentration), mit p-Aminoazotoluol in 37% (mit 5%iger Konzentration), mit p-Aminobenzoesäure in keinem Fall. Aus dem Vergleich der Sensibilisierungsquoten ist zu schließen, daß p-Aminodiphenylamin und p-Phenylendiamin als starke Sensibilisatoren anzusehen sind, p-Aminoazotoluol und p-Toluylendiamin einen geringeren Effekt aufwiesen und p-Aminobenzoesäure unwirksam blieb.
    Notes: Summary Skin tests with derivates of para-substituted benzene were carried out at 4 different concentrations on a total of 160 guinea pigs. Results were evaluated macroscopically and histologically. Each substance was tested on 32 animals. Sensitization was obtained with p-aminodiphenylamine in about 50%, with p-toluylenediamine in about 25%, with 1% and 2% p-phenylenediamine in 62%, with 5% p-aminoazotoluene in 37%, whereas no sensitization was observed with p-aminobenzoic acid. Thus, p-aminodiphenylamine, p-toluylenediamine and p-phenylenediamine must be regarded as highly sensitizing agents, whereas p-aminoazotoluene and p-aminobenzoic acid seem to be less effective respectively non sensitizing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00447160
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  • 8
    Electronic Resource
    Electronic Resource
    Neutrophil adhesion to histamine stimulated cultured endothelial cells is primarily mediated via activation of phospholipase C and nitric oxide synthase isozymes (1998)
    Springer
    Inflammation research 47 (1998), S. 256-264 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Histamine — Histamine receptors — Inflammation — Neutrophils — Signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: In order to understand the underlying mechanism of histamine stimulated inflammatory responses, histamine receptor subtypes and signal transduction pathways by which histamine mediates the stimulation of neutrophil adhesion to endothelial cells has been studied in vitro.¶Material: Human neutrophils and human umbilical vein endothelial cells.¶Treatment: Confluent human endothelial cell layer were incubated with histamine (1 mM), H1, H2 or H3 receptor agonists: fluorophenylhistamine (10 μM), amthamine (10 μm), methylhistamine (10 μM), respectively. Ten minutes prior to histamine (1 mM) stimulation H1, H2 or H3 receptor antagonists (dimethindene, 100 μM; famotidine, 100 μM, thioperamid 100 μM, respectively) were added. Histamine stimulated signal transduction pathways were inhibited by adding phospholipase C inhibitor 2-nitro-4-carboxyphenyl N,N-diphenylcarbamat (200 μM), adenylate cyclase inhibitor 9-(2 tetrahydrofuryl)adenine (80 μM), nitric oxide synthase isozymes inhibitor S-ethylisothiourea (1 μM) or guanylate cyclase inhibitor (LY 83583; 10 μM). Neutrophil adhesion was monitored at 30, 60, 90, 120, 150, 180 and 210 min.¶Methods: Neutrophil adhesion to endothelial cells was quantified by analysing alkaline phosphatase activity.¶Results: Histamine stimulation of endothelial cells resulted in a biphasic time and concentration dependent pattern of neutrophil adhesion. This pattern of neutrophil adhesion was mimicked by stimulation of endothelial cells with H1 or H2 agonists. Stimulation of endothelial cells with an H3 agonist had no effect on neutrophil binding. Inhibition of phospholipase C (PLC), nitric oxide synthase isozymes (NOS) or guanylate cyclase (GC) resulted in a significant decrease of neutrophil binding to histamine or agonist stimulated endothelial cells. An increase of neutrophil binding to unstimulated or to agonist stimulated endothelial cells was observed during inhibition of adenylate cyclase.¶Conclusions: Our results suggest that histamine stimulated neutrophil adhesion is due to H1 and H2 receptor mediated activation of PLC, NOS and GC. Increase of cAMP concentration seems to mediate an inhibitory effect on PMN adhesion to endothelial cells
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050327
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  • 9
    Electronic Resource
    Electronic Resource
    Evidence for reduced traumatization during laparoscopic versus conventional cholecystectomy: Different changes in histamine levels related to special phases of operation (1992)
    Springer
    Inflammation research 36 (1992), S. C162 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of histamine in injury due to trauma or surgical treatment is more than doubtful after more than 70 years of investigation. A comparison of histamine released during conventional versus minimal invasive surgery seems especially useful to elucidate the role of histamine in such important events of the daily clinical life. Histamine is released during conventional cholecystectomy in patients of high age, a special group of risk for perioperative morbidity and mortality. In animal experiments, it was shown that this histamine release is due to technical differences between the two types of operation. Hence histamine release seems to be a suitable parameter for the stimulus-induced approach to stress and trauma. Histamine is localized in high concentrations especially in abdominal tissues. After its release it may cause direct actions at a susceptible myocardium, pulmonary parenchyma or gastrointestinal mucosa. However, histamine release is also a proxy variable for mast cell irritation, stimulation and mediator release. This should not be forgotten when the role of histamine is discussed in shock, ARDS, DIC and other clinically relevant or even life-threatening events in routine surgical care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997323
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  • 10
    Electronic Resource
    Electronic Resource
    Threonine is present instead of cysteine at the active site of urease from Staphylococcus xylosus (1994)
    Springer
    Archives of microbiology 161 (1994), S. 384-392 
    Details
    ISSN: 1432-072X
    Keywords: Key words:Staphylococcus– Urease – Nickel – Nucleotide sequence – Phenylmethanesulfonyl fluoride (PMSF) – Enzyme subunits – Serine protease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. DNA sequence analysis of the structural urease genes from Staphylococcus xylosus revealed that three enzyme subunits are encoded in the order of 11 000, 15 400 and 61 000 (mol. mass), which correspond to the single polypeptide chain of jack bean urease (90 800). Comparing the deduced amino acid sequence of S. xylosus urease with the amino acid sequence of jack bean urease an overall portion of 56% identical residues was found. For S. xylosus urease a subunit structure of (αβγ)4 was proposed, based on the comparison of the deduced amino acid content of the enzyme subunits with the total amino acid content of the purified enzyme. The staphylococcal enzyme contained no cysteine, as deduced from DNA sequence and confirmed by the determination of the total amino acid content in the purified enzyme. Instead of cysteine, known to be catalytically essential in the plant enzyme, and conserved among all bacterial ureases analyzed so far, threonine was found in S. xylosus. This amino acid-exchange was located within a highly conserved domain of 17 amino acids, supposed to be part of the active site. Sequence analysis of the respective region of Staphylococcus saprophyticus urease showed that it also contains threonine instead of cysteine. In contrast to jack bean urease S. xylosus urease was not affected by the SH-group inhibitor dipyridyl disulfide but was completely inhibited by the serine protease inhibitor phenylmethanesulfonyl fluoride. The presented results indicate that in these staphylococcal strains urea hydrolysis might function in a manner similar to the peptide bond cleavage by chymotrypsin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00288947
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