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  • 1
    Electronic Resource
    Electronic Resource
    Diabetic Neuropathy (1990)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 41 (1990), S. 303-317 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.41.020190.001511
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  • 2
    Electronic Resource
    Electronic Resource
    Histopathology of the intestine of Cichlasoma urophthalmus (Günther) infected with metacercariae of Oligogonotylus manteri Watson, 1976 (Digenea: Cryptogonimidae) (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 17 (1994), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1994.tb00247.x
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  • 3
    Electronic Resource
    Electronic Resource
    Pathogenic effects of the eggs of Capillaria cichlasomae (Nematoda: Capillariidea) in the liver of the cichlid Cichlasoma urophthalmus (Günther) in Mexico (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 19 (1996), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1996.tb00697.x
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  • 4
    Electronic Resource
    Electronic Resource
    Steroid receptors in meningiomas (1983)
    Springer
    Acta neuropathologica 62 (1983), S. 134-140 
    Details
    ISSN: 1432-0533
    Keywords: Meningioma ; Estrogen receptor ; Progesterone receptor ; Histochemical assay ; Biochemical assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Meningiomas are more common in females and their course can be affected by changes in the hormonal milieu of the patient. Recently, a few studies have reported the presence of one or more steroid receptors in a small number of meningiomas. We have studied the estrogen and progesterone receptors (ER and PgR) of 11 surgically excised meningiomas. The receptors were assayed biochemically and localized at the cellular level using fluoroceinated estradiol and rhodamine-conjugated progesterone. Considerable amounts of ER were found in 4/11 cases, and PgR was high in 6/11 tumors. Cytoplasmic localization of the steroid binding sites was seen using both tracers. The presence of 10% of cells with two ++ intensity of the fluorescence correlated with tumors having positive ER values (〉10 Fm/mg protein). The presence of nuclear fluorescence and the higher level of PgR seen in some tumors indicate that the ER present is functioning. This study confirms the presence of steroid binding sites in meningiomas and suggests that there may be a role for hormonal manipulation in selected patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684930
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of tetraphenylporphinesulfonate (TPPS) on muscle end-plates in mice (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 201-206 
    Details
    ISSN: 1432-0533
    Keywords: Muscle end-plates ; Porphyric neuropathy ; Electron microscopy ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Motor end-plates were studied in mice at various intervals after a single injection of a synthetic porphyrin, tetraphenylporphinesulfonate (TPPS). Ultrastructurally, excess accumulation of neurofilaments constituted the earliest abnormality. These were followed by atrophy of many nerve terminals and their separation from the postsynaptic area by interposed separation from the postsynaptic area by interposed Schwann cells. Five to 8 months after the injection some postsynaptic areas showed denervation and atrophy. These progressive changes in the nerve terminals were accompanied by secondary changes in the subneural apparatus. Morphometric analysis revealed marked atrophy of the end-plates and significant swelling of preterminal axons. The present findings are suggestive of partial denervation of muscle, occurring after the injection of a synthetic porphyrin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690636
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  • 6
    Electronic Resource
    Electronic Resource
    Distal symmetric polyneuropathy in the spontaneously diabetic BB-Wistar rat (1982)
    Springer
    Acta neuropathologica 58 (1982), S. 39-47 
    Details
    ISSN: 1432-0533
    Keywords: BB-Wistar rat ; Diabetic distal symmetric neuropathy ; Axonal degeneration ; Teased fibers ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distal, symmetric polyneuropathy of the spontaneously diabetic BB-Wistar rat was studied ultrastructurally and by means of teased fiber preparations. Ultrastructural findings consisted of malorientation of the axonal cytoskeleton, followed by axonal atrophy, secondary myelin breakdown and distal Wallerian degeneration. This sequence of structural changes could be confirmed by scoring of pathological abnormalities and morphometric evaluation of teased fibers. Distal sensory nerve fibers were affected earlier and more severely than motor fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692696
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  • 7
    Electronic Resource
    Electronic Resource
    Astroblastoma revisited: A report of three cases (1986)
    Springer
    Acta neuropathologica 70 (1986), S. 10-16 
    Details
    ISSN: 1432-0533
    Keywords: Astroblastoma ; Immunohistopathology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The very existence of astroblastoma has been a question of considerable controversy, although there appears now to be sufficient documentation to establish it as a tenable entity. Due to the rarity of this tumor, little information exists in the literature as to its natural history, efficacy of therapy and its pathological and radiological appearance. We report three cases of astroblastoma, describing their natural history, the response to therapeutic interventions and their light microscopic, ultrastructural and immunohistochemical characteristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689508
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  • 8
    Electronic Resource
    Electronic Resource
    Aldose reductase in the BB rat: isolation, immunological identification and localization in the retina and peripheral nerve (1987)
    Springer
    Diabetologia 30 (1987), S. 244-251 
    Details
    ISSN: 1432-0428
    Keywords: Aldose reductase ; BB rat ; immunocytochemistry ; retina ; peripheral nerve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Aldose reductase was purified from testis of nondiabetic BB rats using DEAE cellulose, hydroxylapatite and sephadex G-100 column chromatography. The molecular weight of the isolated enzyme was found to be 36,500±1000. Antibody against the isolated enzyme was raised in rabbits. It was purified by affinity chromatography, characterised by double immunodiffusion and Western blot analysis and used to localize the enzyme in retina and in peripheral nerve of the BB rat. In the retina, aldose reductase immunoreactivity was seen in the ganglion cells, Müller cell processes, retinal pigment epithelium and in the pericytes and endothelial cells of retinal capillaries. In peripheral nerve, aldose reductase immunoreactivity was found in the paranodal cytoplasm of Schwann cells and in pericytes and endothelial cells of endoneurial capillaries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270423
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  • 9
    Electronic Resource
    Electronic Resource
    The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy (1992)
    Springer
    Diabetologia 35 (1992), S. 560-569 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; neuropathy ; morphometry ; sural nerve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated previously in a systematic manner. Morphometric parameters of nerve fibre damage were measured in four separate fascicles from bilateral sural nerve specimens obtained post-mortem from 13 diabetic and 13 non-diabetic subjects. Intra- and inter-individual coefficients of variation were computed and compared to the magnitude of the differences between normal and diabetic subjects. Several morphometric variables emerged as highly sensitive and reproducible measures of nerve fibre damage suitable for clinical studies of diabetic peripheral polyneuropathy. These observations provide a rational basis for the design of future clinical trials employing morphometric end-points.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400485
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  • 10
    Electronic Resource
    Electronic Resource
    Pancreatic islet allograft prevents basement membrane thickening in the diabetic rat retina (1988)
    Springer
    Diabetologia 31 (1988), S. 175-181 
    Details
    ISSN: 1432-0428
    Keywords: Islet cell transplantation ; streptozotocin-diabetic rats ; basement membrane ; retina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Progressive basement membrane thickening is a characteristic structural abnormality in diabetic tissues in cluding the retina. We examined the effect of pancreatic islet allotransplantation on basement membrane thickening and irregularities in retinal capillaries of the streptozotocin-diabetic rat. Diabetic animals received intraportal or intracerebral pancreatic islet allografts. Animals with functioning allografts demonstrated euglycaemia and a normal body weight gain during the 400-day post-transplantation period. The characteristic thickening of capillary basement membranes was completely prevented in animals with successful transplantation. The present findings suggest that islet allotransplantation may be a rational therapeutic approach in the treatment of diabetes mellitus and the prevention of ensuing secondary complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276852
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